目的:基于循证识别原发性肝癌(PLC)患者腹腔镜精准肝切除术后VTE的危险因素,并据此制定预防策略。方法:选取2023年1月—2024年12月德阳市人民医院收治的121例PLC患者作为研究对象。根据患者是否被诊断为静脉血栓栓塞病(VTE),将患者分为...目的:基于循证识别原发性肝癌(PLC)患者腹腔镜精准肝切除术后VTE的危险因素,并据此制定预防策略。方法:选取2023年1月—2024年12月德阳市人民医院收治的121例PLC患者作为研究对象。根据患者是否被诊断为静脉血栓栓塞病(VTE),将患者分为VTE组(32例)和非VTE组(89例)。基于循证医学思想,参考国内外已发表的相关文献资料进行编制针对PLC患者腹腔镜精准肝切除术后VTE相关因素的专项调查表,并对单因素分析有统计学差异的因素经变量赋值后进行logistic回归分析。结果:体质量指数高、手术时间>240 min、Caprini评分高、卧床时间>48 h、合并门静脉癌栓、术后第1 d D-二聚体>3000μg/L是影响PLC患者腹腔镜精准肝切除术后VTE发生的独立危险因素(OR>1,P<0.05)。结论:影响PLC患者腹腔镜精准肝切除术后VTE发生的独立危险因素较多,因此临床应多加关注此类患者,建议早期及时采取以上预防性干预策略,以期降低PLC患者腹腔镜精准肝切除术后VTE发生率。展开更多
Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immun...Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immune tolerance of cancer cells.The classical theory holds that prostate apoptosis response-4(PAR-4)is a tumor suppressor protein.However,our recent research has found that PAR-4 has a biological function of promoting cancer in hepatocellular carcinoma(HCC),and our analysis shows that PAR-4 can be modified of lactic acid.These research evidences suggest that PAR-4 lactylation modification may drive immune tolerance in HCC.Therefore,inhibiting PAR-4 lactylation modification is very likely to increase the sensitivity of HCC to immunotherapy.展开更多
The published article titled“MicroRNA-133b Inhibits Proliferation,Cellular Migration,and Invasion via Targeting LASP1 in Hepatocarcinoma Cells”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1269–1282.
Over the past ten years,numerous papers have been published on the use of indocyanine green(ICG)fluorescence in liver surgery for hepatocellular carcinoma(HCC).There are many different applications.The first involves ...Over the past ten years,numerous papers have been published on the use of indocyanine green(ICG)fluorescence in liver surgery for hepatocellular carcinoma(HCC).There are many different applications.The first involves targeting superficial tumors in patients with macronodular cirrhosis and an irregular liver surface.In a minimally invasive setting,the lack of tactile feedback on the hepatic surface makes detecting subcapsular HCC with ultrasound alone challenging.ICG fusion images can mimic the tactile feedback of the hand and act as an ultrasound booster.ICG fluorescence can be used to evaluate tumor residues after minimally invasive thermal ablation.ICG fluorescence imaging can also be used to identify the grade of HCC early on and evaluate the microinvasive component.展开更多
文摘目的:基于循证识别原发性肝癌(PLC)患者腹腔镜精准肝切除术后VTE的危险因素,并据此制定预防策略。方法:选取2023年1月—2024年12月德阳市人民医院收治的121例PLC患者作为研究对象。根据患者是否被诊断为静脉血栓栓塞病(VTE),将患者分为VTE组(32例)和非VTE组(89例)。基于循证医学思想,参考国内外已发表的相关文献资料进行编制针对PLC患者腹腔镜精准肝切除术后VTE相关因素的专项调查表,并对单因素分析有统计学差异的因素经变量赋值后进行logistic回归分析。结果:体质量指数高、手术时间>240 min、Caprini评分高、卧床时间>48 h、合并门静脉癌栓、术后第1 d D-二聚体>3000μg/L是影响PLC患者腹腔镜精准肝切除术后VTE发生的独立危险因素(OR>1,P<0.05)。结论:影响PLC患者腹腔镜精准肝切除术后VTE发生的独立危险因素较多,因此临床应多加关注此类患者,建议早期及时采取以上预防性干预策略,以期降低PLC患者腹腔镜精准肝切除术后VTE发生率。
基金supported by the National Natural Science Foundation of China(Nos.82573045,82460602,82560459)the Hainan Provincial Graduate Student Innovative Research Project(No.Qhys2024-440).
文摘Post-translational modifications(PTMs)regulate the occurrence and development of cancer,and lactylation modification is a new form of PTMs.Recent studies have found that lactic acid modification can regulate the immune tolerance of cancer cells.The classical theory holds that prostate apoptosis response-4(PAR-4)is a tumor suppressor protein.However,our recent research has found that PAR-4 has a biological function of promoting cancer in hepatocellular carcinoma(HCC),and our analysis shows that PAR-4 can be modified of lactic acid.These research evidences suggest that PAR-4 lactylation modification may drive immune tolerance in HCC.Therefore,inhibiting PAR-4 lactylation modification is very likely to increase the sensitivity of HCC to immunotherapy.
文摘The published article titled“MicroRNA-133b Inhibits Proliferation,Cellular Migration,and Invasion via Targeting LASP1 in Hepatocarcinoma Cells”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1269–1282.
文摘Over the past ten years,numerous papers have been published on the use of indocyanine green(ICG)fluorescence in liver surgery for hepatocellular carcinoma(HCC).There are many different applications.The first involves targeting superficial tumors in patients with macronodular cirrhosis and an irregular liver surface.In a minimally invasive setting,the lack of tactile feedback on the hepatic surface makes detecting subcapsular HCC with ultrasound alone challenging.ICG fusion images can mimic the tactile feedback of the hand and act as an ultrasound booster.ICG fluorescence can be used to evaluate tumor residues after minimally invasive thermal ablation.ICG fluorescence imaging can also be used to identify the grade of HCC early on and evaluate the microinvasive component.
