自从二十年代人们认识维生素 A 以来,有关维生素 A 对细胞增殖分化的调节作用的研究内容已不断得到丰富。由维生素 A_1 衍生而来的维甲酸(Retinoic acid,RA,维生素 A 酸)在分子水平对细胞分化的调节和机制近来尤为引人关注。人早幼粒白...自从二十年代人们认识维生素 A 以来,有关维生素 A 对细胞增殖分化的调节作用的研究内容已不断得到丰富。由维生素 A_1 衍生而来的维甲酸(Retinoic acid,RA,维生素 A 酸)在分子水平对细胞分化的调节和机制近来尤为引人关注。人早幼粒白血病细胞株(HL—60)能被 RA 诱导分化的结果导致晚近推出的临床急性早幼粒白血病的诱导分化疗法,并取得了显著的成效,这将为以全新的方位研究白血病的治疗提供了新的楷模。为此本文简要评述近年来维甲酸诱导早幼粒白血病细胞分化的研究进展。展开更多
A Review] The biological characteristics of viral L6565 leukemia cell clone were as follows: (1) The chromosome counts varied 38～114 , and stem cells were 42; (2) Virus particles type A and type C found in the cytopl...A Review] The biological characteristics of viral L6565 leukemia cell clone were as follows: (1) The chromosome counts varied 38～114 , and stem cells were 42; (2) Virus particles type A and type C found in the cytoplasm of clone cells; (3) X-C assays were positive, c- myc and c- fos gene overexpressed in clone cells; (4) Differential markers CD4, CD8, CD45R were negative, CD45RO λ were positive; (5) The supernatant of clone cells could induce T or B lymphocytic leukemia/lymphoma and granulocytic leukemia in SSB strain mice. The leukemogenic effect of concentrate supernatant was stronger than non-concentrate supernatant( P< 0.05); (6) The antisense of the c- myc gene induced low expression of c- myc protein, and inhibited the growth of viral L6565 clone cells.展开更多
文摘自从二十年代人们认识维生素 A 以来,有关维生素 A 对细胞增殖分化的调节作用的研究内容已不断得到丰富。由维生素 A_1 衍生而来的维甲酸(Retinoic acid,RA,维生素 A 酸)在分子水平对细胞分化的调节和机制近来尤为引人关注。人早幼粒白血病细胞株(HL—60)能被 RA 诱导分化的结果导致晚近推出的临床急性早幼粒白血病的诱导分化疗法,并取得了显著的成效,这将为以全新的方位研究白血病的治疗提供了新的楷模。为此本文简要评述近年来维甲酸诱导早幼粒白血病细胞分化的研究进展。
文摘A Review] The biological characteristics of viral L6565 leukemia cell clone were as follows: (1) The chromosome counts varied 38～114 , and stem cells were 42; (2) Virus particles type A and type C found in the cytoplasm of clone cells; (3) X-C assays were positive, c- myc and c- fos gene overexpressed in clone cells; (4) Differential markers CD4, CD8, CD45R were negative, CD45RO λ were positive; (5) The supernatant of clone cells could induce T or B lymphocytic leukemia/lymphoma and granulocytic leukemia in SSB strain mice. The leukemogenic effect of concentrate supernatant was stronger than non-concentrate supernatant( P< 0.05); (6) The antisense of the c- myc gene induced low expression of c- myc protein, and inhibited the growth of viral L6565 clone cells.
