Hodgkin lymphoma(HL)is a heterogenous lymphoproliferative disorder of B-cell origin and represents one of the most common malignancies in children and young adults.In addition to well-known underlying factors-such as ...Hodgkin lymphoma(HL)is a heterogenous lymphoproliferative disorder of B-cell origin and represents one of the most common malignancies in children and young adults.In addition to well-known underlying factors-such as Epstein-Barr virus infection-the familial aggregation demonstrated in large population studies suggested a genetic predisposition.First-degree relatives of patients with HL have an approximately threefold increased risk of developing the disease compared to the general population.These observations have recently prompted several whole-genome studies in affected families,identifying variants possibly implicated in lymphomagenesis,including alterations in DICER1(a member of the ribonuclease III family),POT1(protection of telomeres 1),KDR(kinase insert domain receptor),KLHDC8B(kelch domain-containing protein 8B),PAX5(paired box protein 5),GATA3(GATA binding protein 3),IRF7(interferon regulatory factor 7),EEF2KMT(eukaryotic elongation factor 2 lysine methyltransferase),and POLR1E(RNA polymerase I subunit E).In this article,we review current insights into the etiopathogenesis and risks of familial HL,and present case reports involving two sisters diagnosed with HL nearly 17 years apart.Recognizing the risk for first-degree relatives may potentially increase awareness of early symptoms among family members of HL patients,leading to earlier diagnosis and better outcomes.Conversely,understanding that the hereditary risk,though higher than in the general population,remains relatively low may provide reassurance for affected families.展开更多
弥漫性大B细胞淋巴瘤(Diffuse large B cell lymphoma,DLBCL)作为非霍奇金淋巴瘤(Non-Hodgkin′s lymphoma,NHL)最常见的亚型之一,侵袭性强,结外受累以胃肠道为主,但原发于纵隔并侵犯气道者罕见。本中心就一例原发于纵隔并侵犯气道所致...弥漫性大B细胞淋巴瘤(Diffuse large B cell lymphoma,DLBCL)作为非霍奇金淋巴瘤(Non-Hodgkin′s lymphoma,NHL)最常见的亚型之一,侵袭性强,结外受累以胃肠道为主,但原发于纵隔并侵犯气道者罕见。本中心就一例原发于纵隔并侵犯气道所致重度大气道狭窄的DLBCL患者的处理过程进行报道,并对相关文献进行复习。展开更多
文摘Hodgkin lymphoma(HL)is a heterogenous lymphoproliferative disorder of B-cell origin and represents one of the most common malignancies in children and young adults.In addition to well-known underlying factors-such as Epstein-Barr virus infection-the familial aggregation demonstrated in large population studies suggested a genetic predisposition.First-degree relatives of patients with HL have an approximately threefold increased risk of developing the disease compared to the general population.These observations have recently prompted several whole-genome studies in affected families,identifying variants possibly implicated in lymphomagenesis,including alterations in DICER1(a member of the ribonuclease III family),POT1(protection of telomeres 1),KDR(kinase insert domain receptor),KLHDC8B(kelch domain-containing protein 8B),PAX5(paired box protein 5),GATA3(GATA binding protein 3),IRF7(interferon regulatory factor 7),EEF2KMT(eukaryotic elongation factor 2 lysine methyltransferase),and POLR1E(RNA polymerase I subunit E).In this article,we review current insights into the etiopathogenesis and risks of familial HL,and present case reports involving two sisters diagnosed with HL nearly 17 years apart.Recognizing the risk for first-degree relatives may potentially increase awareness of early symptoms among family members of HL patients,leading to earlier diagnosis and better outcomes.Conversely,understanding that the hereditary risk,though higher than in the general population,remains relatively low may provide reassurance for affected families.
文摘弥漫性大B细胞淋巴瘤(Diffuse large B cell lymphoma,DLBCL)作为非霍奇金淋巴瘤(Non-Hodgkin′s lymphoma,NHL)最常见的亚型之一,侵袭性强,结外受累以胃肠道为主,但原发于纵隔并侵犯气道者罕见。本中心就一例原发于纵隔并侵犯气道所致重度大气道狭窄的DLBCL患者的处理过程进行报道,并对相关文献进行复习。
