目的:探讨辅助性T细胞(helper T cell,Th)Th1/Th2、Th17/调节性T细胞(regulatory T cell,Treg)失衡与儿童激素耐药型肾病综合征(steroid‑resistant nephrotic syndrome,SRNS)的相关性。方法:招募原发性肾病综合征患儿142例,给予4周的糖...目的:探讨辅助性T细胞(helper T cell,Th)Th1/Th2、Th17/调节性T细胞(regulatory T cell,Treg)失衡与儿童激素耐药型肾病综合征(steroid‑resistant nephrotic syndrome,SRNS)的相关性。方法:招募原发性肾病综合征患儿142例,给予4周的糖皮质激素治疗,根据治疗反应将患儿分为激素敏感型肾病综合征(steroid‑sensitive nephrotic syndrome,SSNS)31例(SSNS组)和SRNS 111例(SRNS组),另选择53例健康儿童作为对照组。检测外周血Th1/Th2、Th17/Treg,分析影响SRNS的相关因素以及Th1/Th2、Th17/Treg诊断SRNS的价值。结果:SRNS组、SSNS组外周血Th2、Th17、Th17/Treg比值水平高于对照组(P<0.05),且SRNS组高于SSNS组(P<0.05),SRNS组、SSNS组Th1、Treg、Th1/Th2比值低于对照组(P<0.05),且SRNS组低于SSNS组(P<0.05)。镜下血尿、尿蛋白、Th17/Treg是SRNS的危险因素(P<0.05),Th1/Th2是保护因素(P<0.05)。联合Th1/Th2、Th17/Treg诊断SRNS的曲线下面积为0.831,高于单独Th1/Th2、Th17/Treg(P<0.05)。结论:SRNS患儿外周血Th1/Th2降低,Th17/Treg增高与SRNS发生有关,是诊断SRNS的潜在生物学标志物。展开更多
Urinary tract infections(UTIs)are among the most prevalent pediatric bacterial infections,and undertreated episodes may lead to renal scarring,hypertension,or chronic kidney disease.Multidrug-resistant(MDR)Enterobacte...Urinary tract infections(UTIs)are among the most prevalent pediatric bacterial infections,and undertreated episodes may lead to renal scarring,hypertension,or chronic kidney disease.Multidrug-resistant(MDR)Enterobacterales have been increasingly reported in children,with higher rates in Asian and Middle Eastern settings than in high-income countries[1,2].展开更多
文摘目的:探讨辅助性T细胞(helper T cell,Th)Th1/Th2、Th17/调节性T细胞(regulatory T cell,Treg)失衡与儿童激素耐药型肾病综合征(steroid‑resistant nephrotic syndrome,SRNS)的相关性。方法:招募原发性肾病综合征患儿142例,给予4周的糖皮质激素治疗,根据治疗反应将患儿分为激素敏感型肾病综合征(steroid‑sensitive nephrotic syndrome,SSNS)31例(SSNS组)和SRNS 111例(SRNS组),另选择53例健康儿童作为对照组。检测外周血Th1/Th2、Th17/Treg,分析影响SRNS的相关因素以及Th1/Th2、Th17/Treg诊断SRNS的价值。结果:SRNS组、SSNS组外周血Th2、Th17、Th17/Treg比值水平高于对照组(P<0.05),且SRNS组高于SSNS组(P<0.05),SRNS组、SSNS组Th1、Treg、Th1/Th2比值低于对照组(P<0.05),且SRNS组低于SSNS组(P<0.05)。镜下血尿、尿蛋白、Th17/Treg是SRNS的危险因素(P<0.05),Th1/Th2是保护因素(P<0.05)。联合Th1/Th2、Th17/Treg诊断SRNS的曲线下面积为0.831,高于单独Th1/Th2、Th17/Treg(P<0.05)。结论:SRNS患儿外周血Th1/Th2降低,Th17/Treg增高与SRNS发生有关,是诊断SRNS的潜在生物学标志物。
文摘Urinary tract infections(UTIs)are among the most prevalent pediatric bacterial infections,and undertreated episodes may lead to renal scarring,hypertension,or chronic kidney disease.Multidrug-resistant(MDR)Enterobacterales have been increasingly reported in children,with higher rates in Asian and Middle Eastern settings than in high-income countries[1,2].
