目的分析新生儿脐动脉血气指标与阿普加(Apgar)评分的相关性。方法选取294例新生儿作为研究对象,根据出生1 min Apgar评分不同分为研究组(Apgar评分≤7分,22例)、对照组(Apgar评分8~10分,272例)。比较两组出生1 min Apgar评分、脐动脉...目的分析新生儿脐动脉血气指标与阿普加(Apgar)评分的相关性。方法选取294例新生儿作为研究对象,根据出生1 min Apgar评分不同分为研究组(Apgar评分≤7分,22例)、对照组(Apgar评分8~10分,272例)。比较两组出生1 min Apgar评分、脐动脉血气指标[pH值、血乳酸(Lac)、剩余碱(BE)],采用Pearson相关性分析法分析脐动脉血气指标与Apgar评分的相关性。结果研究组出生1 min Apgar评分(5.78±0.39)分、pH值(7.18±0.16)、BE(-10.14±1.13)mmol/L低于对照组的(8.59±0.41)分、(7.26±0.02)、(-3.24±1.02)mmol/L,Lac(8.46±1.14)mmol/L高于对照组的(5.02±0.21)mmol/L(P<0.05)。Pearson相关性分析结果显示,pH值、BE与出生1 min Apgar评分呈正相关(r=0.607、0.626,P<0.05);Lac与出生1 min Apgar评分呈负相关(r=-0.780,P<0.05)。结论相较于出生1 min Apgar评分8~10分的新生儿,Apgar评分≤7分的新生儿pH值、BE更低,Lac更高,新生儿脐动脉血气指标(pH值、BE、Lac)与Apgar评分关系密切,将脐动脉血气指标与Apgar评分同时应用可为后续开展临床诊疗新生儿窒息工作提供参考。展开更多
目的探讨早产儿出生时血清类胡萝卜素水平与其健康状况之间的相关性。方法回顾性分析2021年7月至2023年7月在赣州市人民医院新生儿科接受治疗的11名出生胎龄<37周早产儿的临床资料。收集早产儿的基础信息(如性别、胎龄、体质量、Apga...目的探讨早产儿出生时血清类胡萝卜素水平与其健康状况之间的相关性。方法回顾性分析2021年7月至2023年7月在赣州市人民医院新生儿科接受治疗的11名出生胎龄<37周早产儿的临床资料。收集早产儿的基础信息(如性别、胎龄、体质量、Apgar评分等)及血清类胡萝卜素水平。分析早产儿血清类胡萝卜素水平,采用Spearman相关分析早产儿血清类胡萝卜素与Apgar评分的相关性,并比较血清类胡萝卜素不同浓度早产儿的Apgar评分。结果11名早产儿中男性5名(45.5%),女性6名(54.5%);出生胎龄31.3~35.7周,平均(34.0±1.7)周;出生体质量1100~2200 g,平均(1905.5±827.8)g;1 min Apgar评分6~10分,平均(9±1.3)分,5 min Apgar评分8~10分,平均(9.8±0.6)分。早产儿的血清叶黄素、玉米黄质和β-隐黄质的中位水平分别为0.098 g/m L,0.042 g/m L和0.40 g/m L;Spearman相关分析结果显示,早产儿的血清叶黄素类胡萝卜素水平与1 min Apgar评分及5 min Apgar评分均无相关性(P>0.05);血清高浓度叶黄素组和玉米黄质组早产儿的1 min Apgar评分明显高于低浓度组,差异均有统计学意义(P<0.05),但高低浓度β-隐黄质组的早产儿的1 min Apgar评分比较差异无统计学意义(P>0.05)。结论本研究未能发现早产儿血清类胡萝卜素水平与Apgar评分之间的相关性。然而,高浓度叶黄素和玉米黄质可能对早产儿的短期健康状况(如Apgar评分)有积极影响。因此,在早产儿的护理中,关注血清类胡萝卜素的水平可能具有重要的临床意义。展开更多
Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understandin...Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understanding of the pathophysiological substrate underpinning these changes in brain structure and function is limited.The objective of this review is to summarize the growing evidence from animal trials and human cohort studies that suggest exposure to infection/inflammation during the perinatal period promotes regional impairments in neuronal maturation and function,including loss of high-frequency electroencephalographic activity,and reduced growth and arborization of cortical dendrites and dendritic spines resulting in reduced cortical volume.These inflammation-induced disturbances to neuronal structure and function are likely to underpin subsequent disturbances to cortical development and connectivity in fetuses and/or newborns exposed to infection/inflammation during the perinatal period,leading,in the long term,to impaired neurodevelopment.The combined use of early electroencephalography monitoring with neuroimaging techniques that enable detailed evaluation of brain microstructure,and the use of therapeutics that successfully target systemic and central nervous system inflammation could provide an effective strategy for early detection and therapeutic intervention.展开更多
文摘目的分析新生儿脐动脉血气指标与阿普加(Apgar)评分的相关性。方法选取294例新生儿作为研究对象,根据出生1 min Apgar评分不同分为研究组(Apgar评分≤7分,22例)、对照组(Apgar评分8~10分,272例)。比较两组出生1 min Apgar评分、脐动脉血气指标[pH值、血乳酸(Lac)、剩余碱(BE)],采用Pearson相关性分析法分析脐动脉血气指标与Apgar评分的相关性。结果研究组出生1 min Apgar评分(5.78±0.39)分、pH值(7.18±0.16)、BE(-10.14±1.13)mmol/L低于对照组的(8.59±0.41)分、(7.26±0.02)、(-3.24±1.02)mmol/L,Lac(8.46±1.14)mmol/L高于对照组的(5.02±0.21)mmol/L(P<0.05)。Pearson相关性分析结果显示,pH值、BE与出生1 min Apgar评分呈正相关(r=0.607、0.626,P<0.05);Lac与出生1 min Apgar评分呈负相关(r=-0.780,P<0.05)。结论相较于出生1 min Apgar评分8~10分的新生儿,Apgar评分≤7分的新生儿pH值、BE更低,Lac更高,新生儿脐动脉血气指标(pH值、BE、Lac)与Apgar评分关系密切,将脐动脉血气指标与Apgar评分同时应用可为后续开展临床诊疗新生儿窒息工作提供参考。
文摘目的探讨早产儿出生时血清类胡萝卜素水平与其健康状况之间的相关性。方法回顾性分析2021年7月至2023年7月在赣州市人民医院新生儿科接受治疗的11名出生胎龄<37周早产儿的临床资料。收集早产儿的基础信息(如性别、胎龄、体质量、Apgar评分等)及血清类胡萝卜素水平。分析早产儿血清类胡萝卜素水平,采用Spearman相关分析早产儿血清类胡萝卜素与Apgar评分的相关性,并比较血清类胡萝卜素不同浓度早产儿的Apgar评分。结果11名早产儿中男性5名(45.5%),女性6名(54.5%);出生胎龄31.3~35.7周,平均(34.0±1.7)周;出生体质量1100~2200 g,平均(1905.5±827.8)g;1 min Apgar评分6~10分,平均(9±1.3)分,5 min Apgar评分8~10分,平均(9.8±0.6)分。早产儿的血清叶黄素、玉米黄质和β-隐黄质的中位水平分别为0.098 g/m L,0.042 g/m L和0.40 g/m L;Spearman相关分析结果显示,早产儿的血清叶黄素类胡萝卜素水平与1 min Apgar评分及5 min Apgar评分均无相关性(P>0.05);血清高浓度叶黄素组和玉米黄质组早产儿的1 min Apgar评分明显高于低浓度组,差异均有统计学意义(P<0.05),但高低浓度β-隐黄质组的早产儿的1 min Apgar评分比较差异无统计学意义(P>0.05)。结论本研究未能发现早产儿血清类胡萝卜素水平与Apgar评分之间的相关性。然而,高浓度叶黄素和玉米黄质可能对早产儿的短期健康状况(如Apgar评分)有积极影响。因此,在早产儿的护理中,关注血清类胡萝卜素的水平可能具有重要的临床意义。
基金supported by National Health and Medical Research Council of Australia(APP1090890 and APP1164954)Cerebral Palsy Alliance(ERG02123)the Victorian Government’s Operational Infrastructure Support Program。
文摘Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understanding of the pathophysiological substrate underpinning these changes in brain structure and function is limited.The objective of this review is to summarize the growing evidence from animal trials and human cohort studies that suggest exposure to infection/inflammation during the perinatal period promotes regional impairments in neuronal maturation and function,including loss of high-frequency electroencephalographic activity,and reduced growth and arborization of cortical dendrites and dendritic spines resulting in reduced cortical volume.These inflammation-induced disturbances to neuronal structure and function are likely to underpin subsequent disturbances to cortical development and connectivity in fetuses and/or newborns exposed to infection/inflammation during the perinatal period,leading,in the long term,to impaired neurodevelopment.The combined use of early electroencephalography monitoring with neuroimaging techniques that enable detailed evaluation of brain microstructure,and the use of therapeutics that successfully target systemic and central nervous system inflammation could provide an effective strategy for early detection and therapeutic intervention.
