目的探讨中国人群尿石症患病的影响因素,为尿石症的预防控制提供参考依据。方法检索中国知网、万方、维普、中国生物医学、Pubmed、Web of science和Embase数据库自建库截至2020年8月发表的所有关于中国人群尿石症危险因素的病例对照研...目的探讨中国人群尿石症患病的影响因素,为尿石症的预防控制提供参考依据。方法检索中国知网、万方、维普、中国生物医学、Pubmed、Web of science和Embase数据库自建库截至2020年8月发表的所有关于中国人群尿石症危险因素的病例对照研究;采用Stata 15.0软件对数据进行Meta分析。结果最终纳入22篇文献,尿石症患者共计3583例,对照组人群共计4850例。Meta分析结果显示,一级亲属家族史、高动物蛋白质、高脂饮食、高盐饮食、高糖饮食、泌尿系统患病史、身体质量指数>25 kg/m^(2)、饮酒均是中国人群尿石症患病的危险因素(P均<0.05);较高文化程度、日饮水量多、多食奶及奶制品、多食蔬菜、多食水果、经常体育锻炼均是中国人群尿石症患病的保护因素(P均<0.05)。采用逐一剔除文献的方法进行敏感性分析,结果显示稳定性较高,表明本研究的Meta分析结果具有稳健性。本研究共分析15个影响因素,通过Begg's检验分析发表偏倚,显示只有日饮水量多纳入的文献存在一定的发表偏倚(P<0.05)。结论中国尿石症的影响因素众多,主要可通过干预饮食因素和改善生活方式来预防尿石症的发生。展开更多
BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental complic...BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental complications.The majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening methods.CASE SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal head.Subsequent ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV infection.Chromosomal karyotyping and microarray analysis of the fetus yielded no significant abnormalities.Following compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her pregnancy.She ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female neonate.At five months of age,the infant presented with epilepsy and significant growth and developmental delays.CONCLUSION Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal head.Future research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.展开更多
文摘目的探讨中国人群尿石症患病的影响因素,为尿石症的预防控制提供参考依据。方法检索中国知网、万方、维普、中国生物医学、Pubmed、Web of science和Embase数据库自建库截至2020年8月发表的所有关于中国人群尿石症危险因素的病例对照研究;采用Stata 15.0软件对数据进行Meta分析。结果最终纳入22篇文献,尿石症患者共计3583例,对照组人群共计4850例。Meta分析结果显示,一级亲属家族史、高动物蛋白质、高脂饮食、高盐饮食、高糖饮食、泌尿系统患病史、身体质量指数>25 kg/m^(2)、饮酒均是中国人群尿石症患病的危险因素(P均<0.05);较高文化程度、日饮水量多、多食奶及奶制品、多食蔬菜、多食水果、经常体育锻炼均是中国人群尿石症患病的保护因素(P均<0.05)。采用逐一剔除文献的方法进行敏感性分析,结果显示稳定性较高,表明本研究的Meta分析结果具有稳健性。本研究共分析15个影响因素,通过Begg's检验分析发表偏倚,显示只有日饮水量多纳入的文献存在一定的发表偏倚(P<0.05)。结论中国尿石症的影响因素众多,主要可通过干预饮食因素和改善生活方式来预防尿石症的发生。
文摘BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental complications.The majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening methods.CASE SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal head.Subsequent ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV infection.Chromosomal karyotyping and microarray analysis of the fetus yielded no significant abnormalities.Following compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her pregnancy.She ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female neonate.At five months of age,the infant presented with epilepsy and significant growth and developmental delays.CONCLUSION Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal head.Future research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.
