背景:实验显示双膦酸盐对预防股骨头塌陷起到积极作用,但临床应用结果存在一定争议,且由于系统用药的不良反应较多,近期对局部应用的研究逐渐增多。目的:综述双膦酸盐治疗股骨头缺血性坏死的研究进展。方法:由2位共同第一作者检索PubMe...背景:实验显示双膦酸盐对预防股骨头塌陷起到积极作用,但临床应用结果存在一定争议,且由于系统用药的不良反应较多,近期对局部应用的研究逐渐增多。目的:综述双膦酸盐治疗股骨头缺血性坏死的研究进展。方法:由2位共同第一作者检索PubMed数据库及CNKI中国期刊全文数据库收录的双膦酸盐治疗股骨头缺血性坏死的相关文章,英文检索词为"osteonecrosis of the femoral head,bisphosphonates,systemic therapy,topical therapy,osteogenesis,bone destruction,bone remodeling",中文检索词为"股骨头坏死、双膦酸盐、系统、局部、成骨、破骨、骨重塑",按纳入和排除标准共纳入文献62篇进行归纳总结。结果与结论:双膦酸盐对成骨细胞既有抑制作用也有激活作用,目前存在一定争议。目前研究显示低浓度双膦酸盐可促进成骨细胞的增殖,而高浓度起到抑制作用。长期系统应用双膦酸盐会有下颌骨坏死等不良反应,而局部应用双膦酸盐治疗股骨头缺血性坏死仍停留在实验阶段,且治疗股骨头缺血性坏死的最佳浓度及药效持续时间都尚未确定,在临床应用前仍需进一步的高质量实验研究来阐明。展开更多
Meniscal attachments provide constraint for meniscus and contribute to knee stability. However, the influence of attachments placement on articular mechanical environment remains unclear. The present study aims to cha...Meniscal attachments provide constraint for meniscus and contribute to knee stability. However, the influence of attachments placement on articular mechanical environment remains unclear. The present study aims to characterize the stress deterioration caused by abnormal attachment locations. Different placement of medial meniscal attachments were analyzed with a three-dimensional (3D) finite element (FE) model of knee joint. The articular stress distribution under compressive loadings indicates that abnormal placement of medial meniscal attachments could cause stress deterioration in meniscus and tibia plateau, which may increase the risk of OA. The influence of PMMA relocation was more severe than that of AMMA. The anterior displacement of both AMMA and PMMA could decrease the tibial contact area and therefore weakening the meniscal function of loading transmission. The present study provides an insight into the biomechanical character of meniscal attachments and may help improving the meniscal transplantation in the future.展开更多
文摘背景:实验显示双膦酸盐对预防股骨头塌陷起到积极作用,但临床应用结果存在一定争议,且由于系统用药的不良反应较多,近期对局部应用的研究逐渐增多。目的:综述双膦酸盐治疗股骨头缺血性坏死的研究进展。方法:由2位共同第一作者检索PubMed数据库及CNKI中国期刊全文数据库收录的双膦酸盐治疗股骨头缺血性坏死的相关文章,英文检索词为"osteonecrosis of the femoral head,bisphosphonates,systemic therapy,topical therapy,osteogenesis,bone destruction,bone remodeling",中文检索词为"股骨头坏死、双膦酸盐、系统、局部、成骨、破骨、骨重塑",按纳入和排除标准共纳入文献62篇进行归纳总结。结果与结论:双膦酸盐对成骨细胞既有抑制作用也有激活作用,目前存在一定争议。目前研究显示低浓度双膦酸盐可促进成骨细胞的增殖,而高浓度起到抑制作用。长期系统应用双膦酸盐会有下颌骨坏死等不良反应,而局部应用双膦酸盐治疗股骨头缺血性坏死仍停留在实验阶段,且治疗股骨头缺血性坏死的最佳浓度及药效持续时间都尚未确定,在临床应用前仍需进一步的高质量实验研究来阐明。
基金National Natural Science Foundation of Chinagrant number:10925208,1120101001+1 种基金National Basic Research Program of Chinagrant number:2011CB710901
文摘Meniscal attachments provide constraint for meniscus and contribute to knee stability. However, the influence of attachments placement on articular mechanical environment remains unclear. The present study aims to characterize the stress deterioration caused by abnormal attachment locations. Different placement of medial meniscal attachments were analyzed with a three-dimensional (3D) finite element (FE) model of knee joint. The articular stress distribution under compressive loadings indicates that abnormal placement of medial meniscal attachments could cause stress deterioration in meniscus and tibia plateau, which may increase the risk of OA. The influence of PMMA relocation was more severe than that of AMMA. The anterior displacement of both AMMA and PMMA could decrease the tibial contact area and therefore weakening the meniscal function of loading transmission. The present study provides an insight into the biomechanical character of meniscal attachments and may help improving the meniscal transplantation in the future.
