Tendon-related diseases(TRDs)are increasingly common in the current aging society and impose a significant burden on patients.Despite therapeutic advances,the pathophysiology of TRDs remains poorly understood,hinderin...Tendon-related diseases(TRDs)are increasingly common in the current aging society and impose a significant burden on patients.Despite therapeutic advances,the pathophysiology of TRDs remains poorly understood,hindering effective clinical management.The macrophages are highly plastic immune cells involved in the maintenance of in vivo homeostasis and the injury-healing process.Their dual role in TRDs has been widely investigated,either promoting tenogenic and chondrogenic differentiation or amplifying inflammatory response,underscoring their therapeutic potential for TRDs treatment.Therefore,the review aims to summarize the roles of macrophages in the healing of TRDs,characterized by limited regenerative capacity,and examine strategies for the modulation of macrophage phenotypes to accelerate the regeneration process.Finally,we review applications involving macrophage modulation within the context of tissue engineering of TRDs,providing novel insights for the design of biomaterials-based targeted delivery systems.展开更多
目的观察完全清醒局部麻醉无止血带技术(Wide-awake local anesthesia no tourniquet,WALANT)在拇长屈肌腱或拇长伸肌腱慢性损伤断裂修复术中的应用的效果。方法回顾性分析自2012-02—2022-12在WALANT技术辅助下手术修复的15例拇长屈肌...目的观察完全清醒局部麻醉无止血带技术(Wide-awake local anesthesia no tourniquet,WALANT)在拇长屈肌腱或拇长伸肌腱慢性损伤断裂修复术中的应用的效果。方法回顾性分析自2012-02—2022-12在WALANT技术辅助下手术修复的15例拇长屈肌腱或拇长伸肌腱慢性损伤断裂,取掌长肌腱游离移植修复7例拇长屈肌腱,取示指固有伸肌腱转位修复8例拇长伸肌腱。结果15例均获得随访,随访时间3~20个月,平均10.5个月。术后切口均一期愈合,无切口感染、皮肤坏死、手指坏死、肌腱再次断裂等并发症发生。所有患者均可从事原有工作或正常劳作。末次随访时按中华医学会手外科学会上肢部分功能评定试用标准评定手指功能:优9例,良4例,可2例。结论WALANT技术操作简便,拇长屈肌腱或拇长伸肌腱损伤修复术中即可获得清晰的手术视野调节肌肉张力,保证肌腱缝合质量,术者还可以患者进行良好的沟通,增加患者后期进行康复训练的自信心。展开更多
基金supported by the Guangxi Natural Science Foundation(AD21220065 to JX)the National Natural Science Foundation of China(82102632 and 82160412 to JX)the Guangdong Basic and Applied Basic Research Foundation(2023A1515220072 to ZHD)。
文摘Tendon-related diseases(TRDs)are increasingly common in the current aging society and impose a significant burden on patients.Despite therapeutic advances,the pathophysiology of TRDs remains poorly understood,hindering effective clinical management.The macrophages are highly plastic immune cells involved in the maintenance of in vivo homeostasis and the injury-healing process.Their dual role in TRDs has been widely investigated,either promoting tenogenic and chondrogenic differentiation or amplifying inflammatory response,underscoring their therapeutic potential for TRDs treatment.Therefore,the review aims to summarize the roles of macrophages in the healing of TRDs,characterized by limited regenerative capacity,and examine strategies for the modulation of macrophage phenotypes to accelerate the regeneration process.Finally,we review applications involving macrophage modulation within the context of tissue engineering of TRDs,providing novel insights for the design of biomaterials-based targeted delivery systems.
文摘目的观察完全清醒局部麻醉无止血带技术(Wide-awake local anesthesia no tourniquet,WALANT)在拇长屈肌腱或拇长伸肌腱慢性损伤断裂修复术中的应用的效果。方法回顾性分析自2012-02—2022-12在WALANT技术辅助下手术修复的15例拇长屈肌腱或拇长伸肌腱慢性损伤断裂,取掌长肌腱游离移植修复7例拇长屈肌腱,取示指固有伸肌腱转位修复8例拇长伸肌腱。结果15例均获得随访,随访时间3~20个月,平均10.5个月。术后切口均一期愈合,无切口感染、皮肤坏死、手指坏死、肌腱再次断裂等并发症发生。所有患者均可从事原有工作或正常劳作。末次随访时按中华医学会手外科学会上肢部分功能评定试用标准评定手指功能:优9例,良4例,可2例。结论WALANT技术操作简便,拇长屈肌腱或拇长伸肌腱损伤修复术中即可获得清晰的手术视野调节肌肉张力,保证肌腱缝合质量,术者还可以患者进行良好的沟通,增加患者后期进行康复训练的自信心。
