Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,l...Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,leading to more poisoning incidents.It has a fatality rate as high as 76%after poisoning.[1]Here,we report a successful treatment of a patient with mixed pesticide poisoning caused by lethaldose emamectin benzoate(EB)and chlorfenapyr in the Department of Critical Care Medicine,Yangzhou Hongquan Hospital.展开更多
Acute carbon monoxide(CO) poisoning constitutes a lethal hazard globally,causing substantial mortality and morbidity worldwide.^([1-2]) Studies have shown that multiple mechanisms contribute to acute CO poisoning,incl...Acute carbon monoxide(CO) poisoning constitutes a lethal hazard globally,causing substantial mortality and morbidity worldwide.^([1-2]) Studies have shown that multiple mechanisms contribute to acute CO poisoning,including ischemic-hypoxic injury,reactive oxygen species(ROS) generation and inflammatory responses.^([2-5]) Furthermore,excessive inflammatory responses can induce adverse metabolic changes.^([6-7]) Considering these evidence,an interaction may exist between acute CO poisoning and both inflammatory factors and metabolites.However,the mechanisms through which inflammatory factors mediate CO toxicity via metabolic pathways remain largely unexplored.展开更多
文摘Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,leading to more poisoning incidents.It has a fatality rate as high as 76%after poisoning.[1]Here,we report a successful treatment of a patient with mixed pesticide poisoning caused by lethaldose emamectin benzoate(EB)and chlorfenapyr in the Department of Critical Care Medicine,Yangzhou Hongquan Hospital.
基金supported by the National Natural Science Foundation of China (82372211)。
文摘Acute carbon monoxide(CO) poisoning constitutes a lethal hazard globally,causing substantial mortality and morbidity worldwide.^([1-2]) Studies have shown that multiple mechanisms contribute to acute CO poisoning,including ischemic-hypoxic injury,reactive oxygen species(ROS) generation and inflammatory responses.^([2-5]) Furthermore,excessive inflammatory responses can induce adverse metabolic changes.^([6-7]) Considering these evidence,an interaction may exist between acute CO poisoning and both inflammatory factors and metabolites.However,the mechanisms through which inflammatory factors mediate CO toxicity via metabolic pathways remain largely unexplored.
