坏血病是一种由维生素 C 缺乏引起的营养缺乏病。本文报道的7例典型的坏血病病人是春天4～5月份在新疆食管癌高发区托里县发现的,并对其做了临床检查、部分生化和免疫水平的测定。一、一般资料:7例病人中,男3例,女4例,最小年龄14岁,最...坏血病是一种由维生素 C 缺乏引起的营养缺乏病。本文报道的7例典型的坏血病病人是春天4～5月份在新疆食管癌高发区托里县发现的,并对其做了临床检查、部分生化和免疫水平的测定。一、一般资料:7例病人中,男3例,女4例,最小年龄14岁,最大年龄44岁,均系哈萨克族。从当年11月(入冬)至第二年4月,膳食组成主要以馕、茶、熏肉、酸奶疙瘩等。展开更多
目的探究血浆维生素C与一种新型炎症标志物系统性免疫炎症指数(systemic immune-inflammation index,SII)的关联性。方法本横断面研究采用2003~2006年和2017~2018年国家健康和营养检查调查(The National Health and Nutrition Examinati...目的探究血浆维生素C与一种新型炎症标志物系统性免疫炎症指数(systemic immune-inflammation index,SII)的关联性。方法本横断面研究采用2003~2006年和2017~2018年国家健康和营养检查调查(The National Health and Nutrition Examination Survey,NHANES)的数据集。排除缺失SII相关指标和血浆维生素C,以及<20周岁和妊娠期妇女的参与者。最终纳入人群依据维生素C水平按照三分位法分为T1组(维生素C<40.3μmol/L,n=4397)、T2组(40.3μmol/L≤维生素C≤62.5μmol/L,n=4365)、T3组(维生素C>62.5μmol/L,n=4525)。多元线性回归模型用于研究血浆维生素C与SII的线性关系,并采用加权广义加性模型和平滑曲线拟合进一步探究血浆维生素C水平与SII的非线性关系。结果本研究共纳入13287名成年人。在多元线性回归分析中,维生素C水平与SII呈显著负相关[-3.07,95%CI(-0.74,-0.16),P<0.01];与最低三分位数人群相比,维生素C最高三分位数人群的SII下降了3.94[95%CI(-60.94,-20.45),P<0.01];在按吸烟状况、高血压、血脂异常和糖尿病分层的亚组中,这种负相关得以维持;在按性别分层的亚组分析中,维生素C水平与SII的负相关在女性中显著[-0.52,95%CI(-0.96,-0.07),P<0.05],但在男性中无统计学意义;广义加性模型和平滑曲线拟合结果显示,血浆维生素C水平与SII呈U型关系,拐点为97.72μmol/L。结论血浆维生素C水平与SII呈U型关系,为临床上治疗易发生急性维生素C缺乏的患者提供了参考。展开更多
Objective To compare the blood antioxidant levels and dietary antioxidant intakes between pilots and non-flight staff of the Army Force in The Islamic Republic of Iran. Methods Thirty-seven helicopter pilots and 40 no...Objective To compare the blood antioxidant levels and dietary antioxidant intakes between pilots and non-flight staff of the Army Force in The Islamic Republic of Iran. Methods Thirty-seven helicopter pilots and 40 non-flight staff were included in this study. Their general characteristics were recorded and their weight, height, and waist circumference were measured. Their daily intake of energy and nutrients including antioxidants was assessed using a semi-quantitative food frequency questionnaire. Serum levels of total antioxidant capacity （TAC）, malondialdehyde （MDA）, and glutathione reductase （GR）, glutathione peroxidase （GPx）, superoxide dismutase （SOD）, and catalase （CAT） in red blood cells were also measured. Results The median erythrocytes SOD, serum MDA level and the mean serum level of TAC and erythrocytes GPx were significantly higher in pilots than in non-flight staff. The median vitamin C intake was significantly lower in pilots than in non-flight staff. The serum MDA levels were similar in non-flight staff and pilots when their vitamin C intake was 〈168 mg and significantly lower in non-flight staff than in pilots when their vitamin C intake was 〉168 mg. Conclusion The serum MDA level is lower in non-flight staff than in pilots when their vitamin C intake level is high, indicating that pilots need more vitamin C than non-flight staff.展开更多
文摘坏血病是一种由维生素 C 缺乏引起的营养缺乏病。本文报道的7例典型的坏血病病人是春天4～5月份在新疆食管癌高发区托里县发现的,并对其做了临床检查、部分生化和免疫水平的测定。一、一般资料:7例病人中,男3例,女4例,最小年龄14岁,最大年龄44岁,均系哈萨克族。从当年11月(入冬)至第二年4月,膳食组成主要以馕、茶、熏肉、酸奶疙瘩等。
文摘目的探究血浆维生素C与一种新型炎症标志物系统性免疫炎症指数(systemic immune-inflammation index,SII)的关联性。方法本横断面研究采用2003~2006年和2017~2018年国家健康和营养检查调查(The National Health and Nutrition Examination Survey,NHANES)的数据集。排除缺失SII相关指标和血浆维生素C,以及<20周岁和妊娠期妇女的参与者。最终纳入人群依据维生素C水平按照三分位法分为T1组(维生素C<40.3μmol/L,n=4397)、T2组(40.3μmol/L≤维生素C≤62.5μmol/L,n=4365)、T3组(维生素C>62.5μmol/L,n=4525)。多元线性回归模型用于研究血浆维生素C与SII的线性关系,并采用加权广义加性模型和平滑曲线拟合进一步探究血浆维生素C水平与SII的非线性关系。结果本研究共纳入13287名成年人。在多元线性回归分析中,维生素C水平与SII呈显著负相关[-3.07,95%CI(-0.74,-0.16),P<0.01];与最低三分位数人群相比,维生素C最高三分位数人群的SII下降了3.94[95%CI(-60.94,-20.45),P<0.01];在按吸烟状况、高血压、血脂异常和糖尿病分层的亚组中,这种负相关得以维持;在按性别分层的亚组分析中,维生素C水平与SII的负相关在女性中显著[-0.52,95%CI(-0.96,-0.07),P<0.05],但在男性中无统计学意义;广义加性模型和平滑曲线拟合结果显示,血浆维生素C水平与SII呈U型关系,拐点为97.72μmol/L。结论血浆维生素C水平与SII呈U型关系,为临床上治疗易发生急性维生素C缺乏的患者提供了参考。
基金funded by the Medical University of Armed Forces
文摘Objective To compare the blood antioxidant levels and dietary antioxidant intakes between pilots and non-flight staff of the Army Force in The Islamic Republic of Iran. Methods Thirty-seven helicopter pilots and 40 non-flight staff were included in this study. Their general characteristics were recorded and their weight, height, and waist circumference were measured. Their daily intake of energy and nutrients including antioxidants was assessed using a semi-quantitative food frequency questionnaire. Serum levels of total antioxidant capacity （TAC）, malondialdehyde （MDA）, and glutathione reductase （GR）, glutathione peroxidase （GPx）, superoxide dismutase （SOD）, and catalase （CAT） in red blood cells were also measured. Results The median erythrocytes SOD, serum MDA level and the mean serum level of TAC and erythrocytes GPx were significantly higher in pilots than in non-flight staff. The median vitamin C intake was significantly lower in pilots than in non-flight staff. The serum MDA levels were similar in non-flight staff and pilots when their vitamin C intake was 〈168 mg and significantly lower in non-flight staff than in pilots when their vitamin C intake was 〉168 mg. Conclusion The serum MDA level is lower in non-flight staff than in pilots when their vitamin C intake level is high, indicating that pilots need more vitamin C than non-flight staff.
