This editorial comments on the study by Pierzynowska et al investigating the acini-islet-acinar(AIA)reflex,which integrates the exocrine and endocrine functions of the pancreas.The study investigates whether exogenous...This editorial comments on the study by Pierzynowska et al investigating the acini-islet-acinar(AIA)reflex,which integrates the exocrine and endocrine functions of the pancreas.The study investigates whether exogenous amylase introduced to the interstitial fluid surrounding pancreatic islets can inhibit insulin release.Historically,high serum amylase levels were associated with pancreatitis,but recent findings suggest that low amylase levels are more linked to metabolic diseases like diabetes and obesity.In their experiment,six pigs were used to examine the effects of amylase infusion on insulin release during an intravenous glucose tolerance test.The pigs received different treatments(amylase,saline,or bovine serum albumin),and blood samples were taken over two hours to measure insulin and glucose levels.The results showed amylase delayed glucose-stimulated insulin release,whereas bovine serum albumin increased insulin levels supporting the existence of the AIA reflex and suggesting amylase as a key metabolic regulator.Enzyme supplementation,particularly withα-amylases,may offer therapeutic benefits in preventing and managing metabolic disorders,including diabetes and obesity.Further research is warranted to explore the full scope of amylase’s role in metabolic health and its therapeutic potential.展开更多
目的探讨司美格鲁肽联合西格列汀治疗2型糖尿病(T2DM)的临床效果。方法选取98例T2DM患者,按照抽签法分为对照组和观察组,每组49例。对照组予以西格列汀治疗,观察组予以司美格鲁肽联合西格列汀治疗,比较两组的治疗效果、糖代谢指标、胰...目的探讨司美格鲁肽联合西格列汀治疗2型糖尿病(T2DM)的临床效果。方法选取98例T2DM患者,按照抽签法分为对照组和观察组,每组49例。对照组予以西格列汀治疗,观察组予以司美格鲁肽联合西格列汀治疗,比较两组的治疗效果、糖代谢指标、胰岛功能指标、炎性因子指标及不良反应。结果观察组总治疗有效率为93.88%,高于对照组的77.55%,差异具有统计学意义(P<0.05);治疗12周后,观察组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)、胰岛素抵抗指数(HOMA-IR)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的水平均低于对照组,空腹胰岛素(FINS)水平、胰岛β细胞指数(HOMA-β)均高于对照组(P<0.05);观察组不良反应发生率为10.20%,与对照组的6.12%相比,差异无统计学意义(P>0.05)。结论司美格鲁肽联合西格列汀治疗T2DM效果较好,可改善糖代谢指标与胰岛功能,降低炎性因子水平,且安全性较高。展开更多
目的:探讨母系遗传糖尿病伴耳聋综合征(maternally inherited diabetes and deafness syndrome,MIDD)合并脑动脉闭塞患者的临床、影像学特征及线粒体基因突变家系趋势。方法:通过对1例以糖尿病起病,后因耳聋、头晕和卒中样发作诊断为线...目的:探讨母系遗传糖尿病伴耳聋综合征(maternally inherited diabetes and deafness syndrome,MIDD)合并脑动脉闭塞患者的临床、影像学特征及线粒体基因突变家系趋势。方法:通过对1例以糖尿病起病,后因耳聋、头晕和卒中样发作诊断为线粒体脑肌病伴高乳酸血症和卒中样发作(mitochondrial encephalomyopathy with lactic aci?dosis and stroke?like episode,MELAS)患者及其家系成员的诊疗,结合病史、实验室检查、影像学检查、基因检测及文献复习,分析该家系患者临床特点与致病基因异质性的关系。结果:先证者存在典型的MIDD临床表现,其生化指标和影像学特征符合MIDD诊断。线粒体基因一代测序结果显示存在chrM:3243A>G(tRNA Leu1)突变,对先证者及其母系亲属进行血浆二代测序结果显示,先证者(Ⅲ?1)血液突变率为42.15%,母系亲属也大多存在不同程度点突变。结论:MIDD患者临床表现复杂多样,易合并脑萎缩及脑血管闭塞,对于极度消瘦伴进行性听力减退的糖尿病患者应行基因检测和脑部影像学评估。二代测序有助于明确突变异质性,异质性越高,发病年龄越早,病情越重,需及早预防及诊治。展开更多
基金Supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287,No.NRF-2021S1A5A8062526Local Government-University Cooperation-Based Regional Innovation Projects,No.2021RIS-003.
文摘This editorial comments on the study by Pierzynowska et al investigating the acini-islet-acinar(AIA)reflex,which integrates the exocrine and endocrine functions of the pancreas.The study investigates whether exogenous amylase introduced to the interstitial fluid surrounding pancreatic islets can inhibit insulin release.Historically,high serum amylase levels were associated with pancreatitis,but recent findings suggest that low amylase levels are more linked to metabolic diseases like diabetes and obesity.In their experiment,six pigs were used to examine the effects of amylase infusion on insulin release during an intravenous glucose tolerance test.The pigs received different treatments(amylase,saline,or bovine serum albumin),and blood samples were taken over two hours to measure insulin and glucose levels.The results showed amylase delayed glucose-stimulated insulin release,whereas bovine serum albumin increased insulin levels supporting the existence of the AIA reflex and suggesting amylase as a key metabolic regulator.Enzyme supplementation,particularly withα-amylases,may offer therapeutic benefits in preventing and managing metabolic disorders,including diabetes and obesity.Further research is warranted to explore the full scope of amylase’s role in metabolic health and its therapeutic potential.
文摘目的探讨司美格鲁肽联合西格列汀治疗2型糖尿病(T2DM)的临床效果。方法选取98例T2DM患者,按照抽签法分为对照组和观察组,每组49例。对照组予以西格列汀治疗,观察组予以司美格鲁肽联合西格列汀治疗,比较两组的治疗效果、糖代谢指标、胰岛功能指标、炎性因子指标及不良反应。结果观察组总治疗有效率为93.88%,高于对照组的77.55%,差异具有统计学意义(P<0.05);治疗12周后,观察组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)、胰岛素抵抗指数(HOMA-IR)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的水平均低于对照组,空腹胰岛素(FINS)水平、胰岛β细胞指数(HOMA-β)均高于对照组(P<0.05);观察组不良反应发生率为10.20%,与对照组的6.12%相比,差异无统计学意义(P>0.05)。结论司美格鲁肽联合西格列汀治疗T2DM效果较好,可改善糖代谢指标与胰岛功能,降低炎性因子水平,且安全性较高。
文摘目的:探讨母系遗传糖尿病伴耳聋综合征(maternally inherited diabetes and deafness syndrome,MIDD)合并脑动脉闭塞患者的临床、影像学特征及线粒体基因突变家系趋势。方法:通过对1例以糖尿病起病,后因耳聋、头晕和卒中样发作诊断为线粒体脑肌病伴高乳酸血症和卒中样发作(mitochondrial encephalomyopathy with lactic aci?dosis and stroke?like episode,MELAS)患者及其家系成员的诊疗,结合病史、实验室检查、影像学检查、基因检测及文献复习,分析该家系患者临床特点与致病基因异质性的关系。结果:先证者存在典型的MIDD临床表现,其生化指标和影像学特征符合MIDD诊断。线粒体基因一代测序结果显示存在chrM:3243A>G(tRNA Leu1)突变,对先证者及其母系亲属进行血浆二代测序结果显示,先证者(Ⅲ?1)血液突变率为42.15%,母系亲属也大多存在不同程度点突变。结论:MIDD患者临床表现复杂多样,易合并脑萎缩及脑血管闭塞,对于极度消瘦伴进行性听力减退的糖尿病患者应行基因检测和脑部影像学评估。二代测序有助于明确突变异质性,异质性越高,发病年龄越早,病情越重,需及早预防及诊治。
