本文以豚鼠为实验对象,观察 VitE 对低蛋白饮食诱发的胆色素结石形成的预防作用.实验结果表明,VitE 可以减轻低蛋白饮食诱发的肝脏和胆囊粘膜的慢性炎症改变,降低成石率.对豚鼠的血浆和胆汁中的胆红素、胆汁酸、胆固醇和脂类的分析结果...本文以豚鼠为实验对象,观察 VitE 对低蛋白饮食诱发的胆色素结石形成的预防作用.实验结果表明,VitE 可以减轻低蛋白饮食诱发的肝脏和胆囊粘膜的慢性炎症改变,降低成石率.对豚鼠的血浆和胆汁中的胆红素、胆汁酸、胆固醇和脂类的分析结果表明,VitE 预防胆色素结石的形成是通过降低血中胆固醇和甘油三酯,增加胆汁中的胆汁酸实现的.推测是 VitE 抑制了肝脏 HMG—CoA 还原酶和增强了胆固醇7α—羟化酶活性的结果.展开更多
AIM To explore the risk factors of gallbladder stone recurrence. METHODS A multifactorial analysis was made for 1058 patients in Shanghai area whose gallbladder stones disappeared after different kinds of nonsurgic...AIM To explore the risk factors of gallbladder stone recurrence. METHODS A multifactorial analysis was made for 1058 patients in Shanghai area whose gallbladder stones disappeared after different kinds of nonsurgical therapy, including oral litholytic therapy, extracorporeal shock wave lithotripsy and percutaneous choledocholithotripsy. Serum level of insulin and total bile acid were determined in 122 patients. RESULTS After 1 8 8 years of follow up, the recurrence rate of gallbladder stone was 11 6%, 22 4%, 29 5%, 36 4%, 39 3% and 39 7% respectively within 1, 2, 3, 4, 5 and over 5 years. The risk factors for the recurrence are: primary multiple gallstones ( P <0 05); family history of cholecystolithiasis ( P <0 05); greasy food intake ( P <0 01); low mean value of serum insulin ( P <0 01); and high mean value of total bile acid ( P <0 01). CONCLUSION The recurrence of cholecystolithiasis is related to overintake of high fat and high cholesterol food, and might also be related to low level of serum insulin.展开更多
文摘本文以豚鼠为实验对象,观察 VitE 对低蛋白饮食诱发的胆色素结石形成的预防作用.实验结果表明,VitE 可以减轻低蛋白饮食诱发的肝脏和胆囊粘膜的慢性炎症改变,降低成石率.对豚鼠的血浆和胆汁中的胆红素、胆汁酸、胆固醇和脂类的分析结果表明,VitE 预防胆色素结石的形成是通过降低血中胆固醇和甘油三酯,增加胆汁中的胆汁酸实现的.推测是 VitE 抑制了肝脏 HMG—CoA 还原酶和增强了胆固醇7α—羟化酶活性的结果.
文摘AIM To explore the risk factors of gallbladder stone recurrence. METHODS A multifactorial analysis was made for 1058 patients in Shanghai area whose gallbladder stones disappeared after different kinds of nonsurgical therapy, including oral litholytic therapy, extracorporeal shock wave lithotripsy and percutaneous choledocholithotripsy. Serum level of insulin and total bile acid were determined in 122 patients. RESULTS After 1 8 8 years of follow up, the recurrence rate of gallbladder stone was 11 6%, 22 4%, 29 5%, 36 4%, 39 3% and 39 7% respectively within 1, 2, 3, 4, 5 and over 5 years. The risk factors for the recurrence are: primary multiple gallstones ( P <0 05); family history of cholecystolithiasis ( P <0 05); greasy food intake ( P <0 01); low mean value of serum insulin ( P <0 01); and high mean value of total bile acid ( P <0 01). CONCLUSION The recurrence of cholecystolithiasis is related to overintake of high fat and high cholesterol food, and might also be related to low level of serum insulin.
