目的探究德谷胰岛素利拉鲁肽注射液(insulin degludec/liraglutide,IDegLira)对2型糖尿病(T2DM)合并颈动脉斑块患者的临床疗效。方法86例T2DM合并颈动脉斑块患者,随机分为对照组和观察组,每组43例。试验过程中退出3例,其中对照组41例完...目的探究德谷胰岛素利拉鲁肽注射液(insulin degludec/liraglutide,IDegLira)对2型糖尿病(T2DM)合并颈动脉斑块患者的临床疗效。方法86例T2DM合并颈动脉斑块患者,随机分为对照组和观察组,每组43例。试验过程中退出3例,其中对照组41例完成试验,观察组42例完成试验。对照组给予德谷胰岛素、二甲双胍片联合他汀类药物治疗,同时给予饮食运动教育;观察组将德谷胰岛素替换为IDegLira,其余治疗不变。比较两组受试者治疗前后血脂、血糖、体重指数(BMI)、腰围以及颈动脉内膜中层厚度(IMT)、颈动脉斑块面积及胰岛素用量、不良反应发生情况。结果治疗后,两组IMT、颈动脉斑块面积均较基线改善,且干预组IMT(0.98±0.42)mm和颈动脉斑块面积(16.48±9.68)mm^(2)均小于对照组的(1.21±0.36)mm、(21.21±10.87)mm^(2)(P<0.05)。治疗后,两组空腹血糖(FPG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(HbA1c)水平均低于本组治疗前,且观察组FPG(5.98±1.82)mmol/L、2 h PG(7.48±2.68)mmol/L、HbA1c(6.80±1.24)%均低于对照组的(7.21±1.56)mmol/L、(9.54±4.87)mmol/L、(8.55±2.27)%(P<0.05)。治疗后,两组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均低于本组治疗前,且观察组TC(3.92±0.89)mmol/L、LDL-C(2.80±1.24)mmol/L均低于对照组的(5.14±0.92)、(3.55±1.27)mmol/L(P<0.05);观察组甘油三酯水平低于本组治疗前(P<0.05)。治疗后,观察组腰围、BMI均低于本组治疗前,且观察组腰围(91.68±7.28)cm、BMI(23.26±1.36)kg/m^(2)均低于对照组的(95.24±8.23)cm、(25.74±2.48)kg/m^(2)(P<0.05);观察组胰岛素用量(18.67±5.26)U/d少于对照组的(22.65±6.76)U/d(P<0.05)。两组不良反应发生率比较无明显统计学差异(P>0.05)。结论IDegLira能显著改善T2DM合并颈动脉斑块患者的血管条件,缩小斑块面积,降低心脑血管发病风险,进一步改善患者血糖、血脂水平,同时能减重控制腰围,且不增加药物不良反应,可作为T2DM合并颈动脉斑块患者的优选。展开更多
目的:探讨血小板平均体积(MPV)和血小板分布宽度(PDW)对颈动脉狭窄程度的预测。方法:选择2023年1月至2023年12月青岛大学附属医院收治的265例颈动脉狭窄患者进行回顾分析。根据患者头颈部血管CT显像结果和北美症状性颈动脉内膜切除术试...目的:探讨血小板平均体积(MPV)和血小板分布宽度(PDW)对颈动脉狭窄程度的预测。方法:选择2023年1月至2023年12月青岛大学附属医院收治的265例颈动脉狭窄患者进行回顾分析。根据患者头颈部血管CT显像结果和北美症状性颈动脉内膜切除术试验协作组(NASCET)标准,将患者分为轻度狭窄组(狭窄 Objective: To investigate the predictive value of mean platelet volume (MPV) and platelet distribution width (PDW) on the degree of carotid artery stenosis. Methods: A retrospective analysis was conducted on 265 patients diagnosed with carotid artery stenosis who were admitted to the Affiliated Hospital of Qingdao University between January and December of 2023. The patients’ head and neck vascular CT imaging results were then categorized into three groups according to the criteria established by the North American Symptomatic Carotid Endarterectomy Trial Collaborative Group (NASCET): mild stenosis (stenosis < 30%), moderate stenosis (30% ≤ stenosis < 85%), and severe stenosis (stenosis ≥ 85%). The clinical data and related laboratory indicators of the study participants were meticulously collected. Patients’ general data were systematically enumerated, laboratory data were objectively compared between groups, and the correlation with the degree of carotid artery stenosis was systematically analyzed. Results: The study revealed a positive correlation between PDW and the degree of carotid artery stenosis. Concurrently, HDL demonstrated a negative correlation with the severity of carotid artery stenosis. The findings further indicated that both PDW and HDL independently influenced carotid artery stenosis. However, no significant correlation was observed between MPV and carotid artery stenosis, indicating that other factors might be involved in the etiopathogenesis of this condition. Conclusions: Increased PDW exhibits a direct correlation with the severity of carotid artery stenosis and can serve as a predictive index to evaluate the severity of carotid artery stenosis.展开更多
文摘目的探究德谷胰岛素利拉鲁肽注射液(insulin degludec/liraglutide,IDegLira)对2型糖尿病(T2DM)合并颈动脉斑块患者的临床疗效。方法86例T2DM合并颈动脉斑块患者,随机分为对照组和观察组,每组43例。试验过程中退出3例,其中对照组41例完成试验,观察组42例完成试验。对照组给予德谷胰岛素、二甲双胍片联合他汀类药物治疗,同时给予饮食运动教育;观察组将德谷胰岛素替换为IDegLira,其余治疗不变。比较两组受试者治疗前后血脂、血糖、体重指数(BMI)、腰围以及颈动脉内膜中层厚度(IMT)、颈动脉斑块面积及胰岛素用量、不良反应发生情况。结果治疗后,两组IMT、颈动脉斑块面积均较基线改善,且干预组IMT(0.98±0.42)mm和颈动脉斑块面积(16.48±9.68)mm^(2)均小于对照组的(1.21±0.36)mm、(21.21±10.87)mm^(2)(P<0.05)。治疗后,两组空腹血糖(FPG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(HbA1c)水平均低于本组治疗前,且观察组FPG(5.98±1.82)mmol/L、2 h PG(7.48±2.68)mmol/L、HbA1c(6.80±1.24)%均低于对照组的(7.21±1.56)mmol/L、(9.54±4.87)mmol/L、(8.55±2.27)%(P<0.05)。治疗后,两组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均低于本组治疗前,且观察组TC(3.92±0.89)mmol/L、LDL-C(2.80±1.24)mmol/L均低于对照组的(5.14±0.92)、(3.55±1.27)mmol/L(P<0.05);观察组甘油三酯水平低于本组治疗前(P<0.05)。治疗后,观察组腰围、BMI均低于本组治疗前,且观察组腰围(91.68±7.28)cm、BMI(23.26±1.36)kg/m^(2)均低于对照组的(95.24±8.23)cm、(25.74±2.48)kg/m^(2)(P<0.05);观察组胰岛素用量(18.67±5.26)U/d少于对照组的(22.65±6.76)U/d(P<0.05)。两组不良反应发生率比较无明显统计学差异(P>0.05)。结论IDegLira能显著改善T2DM合并颈动脉斑块患者的血管条件,缩小斑块面积,降低心脑血管发病风险,进一步改善患者血糖、血脂水平,同时能减重控制腰围,且不增加药物不良反应,可作为T2DM合并颈动脉斑块患者的优选。
文摘目的:探讨血小板平均体积(MPV)和血小板分布宽度(PDW)对颈动脉狭窄程度的预测。方法:选择2023年1月至2023年12月青岛大学附属医院收治的265例颈动脉狭窄患者进行回顾分析。根据患者头颈部血管CT显像结果和北美症状性颈动脉内膜切除术试验协作组(NASCET)标准,将患者分为轻度狭窄组(狭窄 Objective: To investigate the predictive value of mean platelet volume (MPV) and platelet distribution width (PDW) on the degree of carotid artery stenosis. Methods: A retrospective analysis was conducted on 265 patients diagnosed with carotid artery stenosis who were admitted to the Affiliated Hospital of Qingdao University between January and December of 2023. The patients’ head and neck vascular CT imaging results were then categorized into three groups according to the criteria established by the North American Symptomatic Carotid Endarterectomy Trial Collaborative Group (NASCET): mild stenosis (stenosis < 30%), moderate stenosis (30% ≤ stenosis < 85%), and severe stenosis (stenosis ≥ 85%). The clinical data and related laboratory indicators of the study participants were meticulously collected. Patients’ general data were systematically enumerated, laboratory data were objectively compared between groups, and the correlation with the degree of carotid artery stenosis was systematically analyzed. Results: The study revealed a positive correlation between PDW and the degree of carotid artery stenosis. Concurrently, HDL demonstrated a negative correlation with the severity of carotid artery stenosis. The findings further indicated that both PDW and HDL independently influenced carotid artery stenosis. However, no significant correlation was observed between MPV and carotid artery stenosis, indicating that other factors might be involved in the etiopathogenesis of this condition. Conclusions: Increased PDW exhibits a direct correlation with the severity of carotid artery stenosis and can serve as a predictive index to evaluate the severity of carotid artery stenosis.
