目的:观察低分子肝素治疗短暂性脑缺血发作(transient ischem ic attack,TIA)的效果。方法:54例TIA患者,随机分为观察组和对照组,观察组给予低分子肝素5 000 IU皮下注射,每12 h 1次,共10天,对照组给予肠溶阿司匹林150 mg口服,每日1次,...目的:观察低分子肝素治疗短暂性脑缺血发作(transient ischem ic attack,TIA)的效果。方法:54例TIA患者,随机分为观察组和对照组,观察组给予低分子肝素5 000 IU皮下注射,每12 h 1次,共10天,对照组给予肠溶阿司匹林150 mg口服,每日1次,观察发作次数及纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)的变化。结果:疗程结束观察组总有效率88.9%,而对照组总有效率66.7%,两组差异有统计学意义(P<0.05),治疗前后FIB、PT、APTT变化不明显(P>0.05),无出血等并发症。结论:低分子肝素治疗TIA有效且安全性好。展开更多
Microbe-related,especially viral-related pandemics have currently paralyzed the world and such pathogenesis is expected to rise in the upcoming years.Although tremendous efforts are being made to develop antiviral dru...Microbe-related,especially viral-related pandemics have currently paralyzed the world and such pathogenesis is expected to rise in the upcoming years.Although tremendous efforts are being made to develop antiviral drugs,very limited progress has been made in this direction.The nanotheranostic approach can be a highly potential rescue to combat this pandemic.Nanoparticles(NPs)due to their high specificity and biofunctionalization ability could be utilized efficiently for prophylaxis,diagnosis and treatment against microbial infections.In this context,titanium oxide,silver,gold NPs,etc.have already been utilized against deadly viruses like influenza,Ebola,HIV,and HBV.The discovery of sophisticated nanovaccines is under investigation and of prime importance to induce reproducible and strong immune responses against difficult pathogens.This review focuses on highlighting the role of various nano-domain materials such as metallic NPs,magnetic NPs,and quantum dots in the biomedical applications to combat the deadly microbial infections.Further,it also discusses the nanovaccines those are already available for various microbial diseases or are in clinical trials.Finally,it gives a perspective on the various nanotechnologies presently employed for efficient diagnosis and therapy against disease causing microbial infections,and how advancement in this field can benefit the health sector remarkably.展开更多
文摘目的:观察低分子肝素治疗短暂性脑缺血发作(transient ischem ic attack,TIA)的效果。方法:54例TIA患者,随机分为观察组和对照组,观察组给予低分子肝素5 000 IU皮下注射,每12 h 1次,共10天,对照组给予肠溶阿司匹林150 mg口服,每日1次,观察发作次数及纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)的变化。结果:疗程结束观察组总有效率88.9%,而对照组总有效率66.7%,两组差异有统计学意义(P<0.05),治疗前后FIB、PT、APTT变化不明显(P>0.05),无出血等并发症。结论:低分子肝素治疗TIA有效且安全性好。
文摘Microbe-related,especially viral-related pandemics have currently paralyzed the world and such pathogenesis is expected to rise in the upcoming years.Although tremendous efforts are being made to develop antiviral drugs,very limited progress has been made in this direction.The nanotheranostic approach can be a highly potential rescue to combat this pandemic.Nanoparticles(NPs)due to their high specificity and biofunctionalization ability could be utilized efficiently for prophylaxis,diagnosis and treatment against microbial infections.In this context,titanium oxide,silver,gold NPs,etc.have already been utilized against deadly viruses like influenza,Ebola,HIV,and HBV.The discovery of sophisticated nanovaccines is under investigation and of prime importance to induce reproducible and strong immune responses against difficult pathogens.This review focuses on highlighting the role of various nano-domain materials such as metallic NPs,magnetic NPs,and quantum dots in the biomedical applications to combat the deadly microbial infections.Further,it also discusses the nanovaccines those are already available for various microbial diseases or are in clinical trials.Finally,it gives a perspective on the various nanotechnologies presently employed for efficient diagnosis and therapy against disease causing microbial infections,and how advancement in this field can benefit the health sector remarkably.
