Objective: to investigate the predictive value of folic acid metabolism gene polymorphism in pregnancy for birth defects. Methods: a total of 2019 pregnant women were collected from our hospital from January 2020 to D...Objective: to investigate the predictive value of folic acid metabolism gene polymorphism in pregnancy for birth defects. Methods: a total of 2019 pregnant women were collected from our hospital from January 2020 to December 2020. The data of MTHFR, Hcy, vitamin B12, folic acid (FA) and other data of pregnant women were detected during the first pregnancy examination. According to the Results of Down's screening, the data of 2019 pregnant women were divided into two groups. Observation group: 1010 pregnant women with moderate and high down's disease risk;Control group: 1009 cases of pregnant women with low or no down's disease risk were given folic acid for 3 months, and then the statistics were collected. Meanwhile, the occurrence of birth defects in the two groups were compared, and the predictive value of folic acid metabolism gene polymorphism on birth defects was analyzed. Results: after intervention, folic acid increased significantly in both groups, Hcy decreased in both groups (P<0.05), but the comparison between groups (P>0.05);The incidence of birth defects in control group was slightly lower than that in observation group (P<0.05). Conclusion: polymorphism of folic acid metabolism gene can be used to preliminarily evaluate the risk of birth defects, and folic acid supplementation can be used to reduce the incidence of birth defects in pregnant women.展开更多
文摘Objective: to investigate the predictive value of folic acid metabolism gene polymorphism in pregnancy for birth defects. Methods: a total of 2019 pregnant women were collected from our hospital from January 2020 to December 2020. The data of MTHFR, Hcy, vitamin B12, folic acid (FA) and other data of pregnant women were detected during the first pregnancy examination. According to the Results of Down's screening, the data of 2019 pregnant women were divided into two groups. Observation group: 1010 pregnant women with moderate and high down's disease risk;Control group: 1009 cases of pregnant women with low or no down's disease risk were given folic acid for 3 months, and then the statistics were collected. Meanwhile, the occurrence of birth defects in the two groups were compared, and the predictive value of folic acid metabolism gene polymorphism on birth defects was analyzed. Results: after intervention, folic acid increased significantly in both groups, Hcy decreased in both groups (P<0.05), but the comparison between groups (P>0.05);The incidence of birth defects in control group was slightly lower than that in observation group (P<0.05). Conclusion: polymorphism of folic acid metabolism gene can be used to preliminarily evaluate the risk of birth defects, and folic acid supplementation can be used to reduce the incidence of birth defects in pregnant women.
