The respiratory-circulatory system, including organs such as the nose, pharynx, larynx, trachea, bronchi, and heart, is an organic community responsible for ventilation and gas exchange. The integrity of its anatomica...The respiratory-circulatory system, including organs such as the nose, pharynx, larynx, trachea, bronchi, and heart, is an organic community responsible for ventilation and gas exchange. The integrity of its anatomical structure directly affects the evolution of pathological processes, and the analysis of their correlation is a core entry point for clinical disease diagnosis, treatment, and mechanism research. Based on this, this paper mainly explores the correlation between the anatomical and pathological characteristics of the respiratory-circulatory system, aiming to provide anatomical and pathological theoretical support for clinical accurate diagnosis, targeted therapy, and prognosis evaluation.展开更多
目的探讨控制营养状态(Controlling Nutritional Status,CONUT)评分、淋巴细胞与单核细胞比值(Lymphocytes to Monocytes Ratio,LMR)及可溶性细胞间黏附分子-1(Soluble Intercellular Adhesion Molecule-1,sICAM-1)与慢性阻塞性肺疾病...目的探讨控制营养状态(Controlling Nutritional Status,CONUT)评分、淋巴细胞与单核细胞比值(Lymphocytes to Monocytes Ratio,LMR)及可溶性细胞间黏附分子-1(Soluble Intercellular Adhesion Molecule-1,sICAM-1)与慢性阻塞性肺疾病加重期(Acute Exacerbation of Chronic Obstructive Pulmonary Disease,AECOPD)患者肺功能及临床转归的关系。方法前瞻性选取江阴市人民医院2023年7月至2024年7月期间收治的161例AECOPD患者,根据临床转归结局分为预后不良组和预后良好组。比较预后不良组和预后良好组的CONUT评分、LMR、sICAM-1及肺功能指标[呼气峰值流量(Peak Expiratory Flow Rate,PEF)、第一秒用力呼气容积与用力肺活量比值(Ratio of Forced Expiratory Volume in One Second to Forced Vital Capacity,FEV1/FVC)、第一秒用力呼气容积占预计值的百分比(Percentage of Forced Expiratory Volume in the First Second to the Projected Value,FEV1%pred)]。采用Pearson相关性分析CONUT评分、LMR及sICAM-1与AECOPD患者肺功能的相关性;采用多因素Logistic回归分析AECOPD患者临床转归的影响因素;采用受试者工作特征(Receiver Operating Characteristic Curve,ROC)曲线分析CONUT评分、LMR及sICAM-1单独及联合检测对AECOPD患者临床转归的预测效能。结果随访3个月,预后不良组有38例,预后良好组有123例。预后不良组的CONUT评分、sICAM-1高于预后良好组,LMR、PEF、FEV1/FVC、FEV1%pred低于预后良好组(P<0.05)。Pearson相关性分析结果显示,CONUT评分及sICAM-1与PEF、FEV1/FVC、FEV1%pred呈负相关,而LMR与PEF、FEV1/FVC、FEV1%pred呈正相关(P<0.05)。两组COPD病程、降钙素原(Procalcitonin,PCT)对比有差异(P<0.05)。CONUT评分升高、sICAM-1升高、LMR下降、COPD病程偏长、PCT升高是AECOPD患者临床转归的危险因素(P<0.05)。CONUT评分、sICAM-1、LMR单独及联合检测预测AECOPD患者临床转归的曲线下面积(Area Under the Curve,AUC)分别为0.896、0.885、0.873、0.952(P<0.05),联合检测的预测效能最高。结论CONUT评分升高、sICAM-1升高、LMR下降、COPD病程偏长、PCT升高是AECOPD患者临床转归的危险因素,且CONUT评分、LMR及sICAM-1三者联合检测对于AECOPD患者临床转归具有较高的预测价值。展开更多
文摘The respiratory-circulatory system, including organs such as the nose, pharynx, larynx, trachea, bronchi, and heart, is an organic community responsible for ventilation and gas exchange. The integrity of its anatomical structure directly affects the evolution of pathological processes, and the analysis of their correlation is a core entry point for clinical disease diagnosis, treatment, and mechanism research. Based on this, this paper mainly explores the correlation between the anatomical and pathological characteristics of the respiratory-circulatory system, aiming to provide anatomical and pathological theoretical support for clinical accurate diagnosis, targeted therapy, and prognosis evaluation.
文摘目的探讨控制营养状态(Controlling Nutritional Status,CONUT)评分、淋巴细胞与单核细胞比值(Lymphocytes to Monocytes Ratio,LMR)及可溶性细胞间黏附分子-1(Soluble Intercellular Adhesion Molecule-1,sICAM-1)与慢性阻塞性肺疾病加重期(Acute Exacerbation of Chronic Obstructive Pulmonary Disease,AECOPD)患者肺功能及临床转归的关系。方法前瞻性选取江阴市人民医院2023年7月至2024年7月期间收治的161例AECOPD患者,根据临床转归结局分为预后不良组和预后良好组。比较预后不良组和预后良好组的CONUT评分、LMR、sICAM-1及肺功能指标[呼气峰值流量(Peak Expiratory Flow Rate,PEF)、第一秒用力呼气容积与用力肺活量比值(Ratio of Forced Expiratory Volume in One Second to Forced Vital Capacity,FEV1/FVC)、第一秒用力呼气容积占预计值的百分比(Percentage of Forced Expiratory Volume in the First Second to the Projected Value,FEV1%pred)]。采用Pearson相关性分析CONUT评分、LMR及sICAM-1与AECOPD患者肺功能的相关性;采用多因素Logistic回归分析AECOPD患者临床转归的影响因素;采用受试者工作特征(Receiver Operating Characteristic Curve,ROC)曲线分析CONUT评分、LMR及sICAM-1单独及联合检测对AECOPD患者临床转归的预测效能。结果随访3个月,预后不良组有38例,预后良好组有123例。预后不良组的CONUT评分、sICAM-1高于预后良好组,LMR、PEF、FEV1/FVC、FEV1%pred低于预后良好组(P<0.05)。Pearson相关性分析结果显示,CONUT评分及sICAM-1与PEF、FEV1/FVC、FEV1%pred呈负相关,而LMR与PEF、FEV1/FVC、FEV1%pred呈正相关(P<0.05)。两组COPD病程、降钙素原(Procalcitonin,PCT)对比有差异(P<0.05)。CONUT评分升高、sICAM-1升高、LMR下降、COPD病程偏长、PCT升高是AECOPD患者临床转归的危险因素(P<0.05)。CONUT评分、sICAM-1、LMR单独及联合检测预测AECOPD患者临床转归的曲线下面积(Area Under the Curve,AUC)分别为0.896、0.885、0.873、0.952(P<0.05),联合检测的预测效能最高。结论CONUT评分升高、sICAM-1升高、LMR下降、COPD病程偏长、PCT升高是AECOPD患者临床转归的危险因素,且CONUT评分、LMR及sICAM-1三者联合检测对于AECOPD患者临床转归具有较高的预测价值。
