目的了解国内外中医师承发展历程、研究热点和新兴趋势。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science(WOS)、Embase、Cochra...目的了解国内外中医师承发展历程、研究热点和新兴趋势。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science(WOS)、Embase、Cochrane Library 2003年1月1日-2023年12月8日中医师承研究文献,使用NoteExpress3.9软件纳入文献,使用Excel2021统计文献发表时间和载文期刊,使用VOSviewer1.6.19、CiteSpace6.2.R4软件对作者、机构、关键词进行可视化分析。结果本研究共纳入文献735篇。2003-2023年,国内外发文量呈波动上升趋势。该领域发文量较高的作者是潘华峰、史亚飞(7篇)。发文量最多的研究机构为北京中医药大学。关键词分析发现,人才培养和中医护理是中医师承研究的发展趋势。关键词共聚为4类,其主题分别为师承教育、院校教育、人才培养和中医传承。结论该领域研究团队间合作较少,机构间合作以同地域或邻近地域为主。中医师承的高质量发展可从教学模式改良、师承制度完善、学术思想传承3个方面进行。展开更多
目的:基于乙二醛酶-1(GLO-1)/晚期糖基化终末产物(AGE)/晚期糖基化终末产物受体(RAGE)通路探讨糖痹康干膏防治2型糖尿病周围神经病变(DPN)的作用机制。方法:56只SD大鼠随机选取8只为正常组,其余48只大鼠予高脂饲料喂养联合腹腔注射链脲...目的:基于乙二醛酶-1(GLO-1)/晚期糖基化终末产物(AGE)/晚期糖基化终末产物受体(RAGE)通路探讨糖痹康干膏防治2型糖尿病周围神经病变(DPN)的作用机制。方法:56只SD大鼠随机选取8只为正常组,其余48只大鼠予高脂饲料喂养联合腹腔注射链脲佐菌素(STZ)诱导2型糖尿病(T2DM)模型,按血糖将大鼠随机分为模型组、唐林组(13.5 mg·kg^(-1))、二甲双胍组(135 mg·kg^(-1))和糖痹康干膏低、中、高剂量组(3、6、12 g·kg^(-1))。干预第4周模型组机械痛痛阈下降则DPN造模成功。每4周测定大鼠的空腹血糖、体质量、机械痛痛阈。干预16周,苏木素-伊红(HE)染色法观察坐骨神经病理形态,免疫组化法检测坐骨神经RAGE、AGE、蛋白激酶C(PKC)、胶原蛋白(COL)表达,实时荧光定量聚合酶链式反应(Real-time PCR)检测坐骨神经RAGE、PKC、Toll样受体(TLR)、COL、GLO-1 m RNA表达。酶联免疫吸附测定法(ELISA)检测大鼠血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、肌酐(CREA)、尿素(UREA)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)-α含量。结果:与正常组比较,模型组空腹血糖升高(P<0.01),体质量及机械痛痛阈降低(P<0.01),血清AST、ALT、CREA、UREA、IL-6、TNF-α升高(P<0.01),坐骨神经RAGE、AGE、PKC表达升高(P<0.01),COL表达降低(P<0.01),TLR、RAGE、PKC m RNA表达升高(P<0.01),COL、GLO-1 m RNA表达降低(P<0.01),坐骨神经形态不规则、轴索形态改变、髓鞘变性。与模型组比较,糖痹康干膏高剂量组各时间,中剂量组给药第4、16周空腹血糖降低(P<0.05,P<0.01);糖痹康干膏各剂量组体质量无明显变化;糖痹康干膏各剂量组在给药后不同时间出现痛阈升高(P<0.05,P<0.01);各剂量组血清IL-6、TNF-α含量下降(P<0.05,P<0.01);糖痹康干膏各剂量组坐骨神经中RAGE、AGE、PKC表达降低(P<0.01),COL表达升高(P<0.01),TLR、RAGE、PKC m RNA表达降低(P<0.01),GLO-1 m RNA表达升高(P<0.05,P<0.01),低、高剂量组COL m RNA表达升高(P<0.01),糖痹康干膏各剂量组病理表现均较模型组病变程度轻。结论:糖痹康干膏具有明显改善DPN作用,其机制可能与调控GLO-1/AGE/RAGE通路作用有关。展开更多
目的借助文献计量学方法可视化分析茯苓研究现状和热点,为科研及临床提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、Web of Science核心集、PubMed...目的借助文献计量学方法可视化分析茯苓研究现状和热点,为科研及临床提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、Web of Science核心集、PubMed 2004年1月1日-2023年9月30日收录的茯苓研究文献。采用NoteExpress3.6.0.9155软件去重,采用Excel2016、CiteSpace6.2.R4和VOSviewer1.6.18.0软件分析年发文量、机构、来源期刊、作者及关键词,并进行可视化展示。结果纳入3861篇中文文献和477篇英文文献,年发文量总体呈上升趋势。中、英文文献发文较多的机构分别为江苏康缘药业股份有限公司和Chinese Academy of Sciences,发文较多的作者分别为王振中和Chen Lin,发文较多的期刊分别为《中草药》和Journal of Ethnopharmacology。高频关键词包括子宫肌瘤、临床疗效、polysaccharide和antioxidant activity等;得到20个聚类与36个突现关键词。结论该领域研究热点集中在茯苓的药理成分及作用机制、临床应用研究和数据挖掘等方面。展开更多
目的分析黄芪多糖研究现状及热点,为进一步研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、PubMed、Web of Science数据库2013年1月1日-2023年7月1日收录的黄芪多糖研究文献...目的分析黄芪多糖研究现状及热点,为进一步研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、PubMed、Web of Science数据库2013年1月1日-2023年7月1日收录的黄芪多糖研究文献。采用NoteExpress3.7软件管理文献并建立数据库,采用Excel2019、CiteSpace6.2.2R、VOSviewer1.6.18软件对纳入文献发文量、作者、机构、关键词进行可视化分析。结果共纳入文献2462篇,其中中文文献1284篇,英文文献1178篇。主要研究机构有甘肃中医药大学、山东中医药大学、北京中医药大学等。中文文献核心作者有刘永琦、王洪新、鲁美丽等,英文文献核心作者有Zhang Wei、Li Ke、Yang Xiaojun等。中文文献高频关键词有黄芪、大鼠、多糖、细胞凋亡、氧化应激等,英文文献高频关键词有expression、in-vitro、oxidative stress、apoptosis等。结论黄芪多糖研究集中于药理作用及机制,机制研究热点涉及肠道菌群、免疫调控、自噬、凋亡,疾病研究热点涉及肿瘤、糖尿病,抗病毒、抗感染等药理作用是研究趋势。展开更多
目的观察针药并用对子宫内膜异位症疼痛大鼠CLEC5A、NLRP3和IL-1β表达的影响,探讨针药并用缓解子宫内膜异位症疼痛的作用机制。方法从48只大鼠随机选取8只进行假手术作为假手术组,剩余40只进行子宫内膜异位症造模,模型建立后根据异位...目的观察针药并用对子宫内膜异位症疼痛大鼠CLEC5A、NLRP3和IL-1β表达的影响,探讨针药并用缓解子宫内膜异位症疼痛的作用机制。方法从48只大鼠随机选取8只进行假手术作为假手术组,剩余40只进行子宫内膜异位症造模,模型建立后根据异位囊肿总体积再区组随机分为模型组、布洛芬组、针灸组、中药组和针药组,每组8只。假手术组、模型组固定并给予等量0.9%生理盐水灌胃,布洛芬组固定并给予布洛芬和0.9%生理盐水混悬液灌胃,针灸组给于固定针灸干预,中药组固定并给予加味没竭片和0.9%生理盐水混悬液灌胃,针药组给予固定针灸和加味没竭片0.9%生理盐水混悬液灌胃。造模后和干预后测量并计算子宫内膜异位症大鼠异位囊肿体积,并测量6组大鼠痛阈。干预后检测6组内膜组织C型凝集素结构域家族5成员A(C-type lectin domain family 5 member A,CLEC5A)、NLR家族Pyrin域蛋白3(NOD-like receptor family pyrin domain containing protein 3,NLRP3)、白细胞介素-1β(interleukin 1β,IL-1β)蛋白和m RNA表达水平。结果针灸组、针药组干预后异位囊肿体积减少值和痛阈增加值均优于模型组(P<0.05)。模型组在位及异位内膜组织中CLEC5A、NLRP3、IL-1β蛋白表达水平高于正常子宫内膜组织(P<0.05)。针灸组、针药组在位及异位内膜组织中CLEC5A和NLRP3蛋白表达水平及异位内膜组织中IL-1β蛋白表达水平低于模型组(P<0.05),针灸组在位内膜IL-1β表达显著低于模型组(P<0.05)。针药组在位内膜组织CLEC5A蛋白表达水平低于布洛芬组和中药组(P<0.05),NLRP3蛋白表达水平低于布洛芬组(P<0.05);异位内膜组织CLEC5A蛋白表达水平低于针灸组、布洛芬组和中药组(P<0.05),NLRP3蛋白表达水平低于布洛芬组和中药组(P<0.05),IL-1β蛋白表达水平显著低于布洛芬组(P<0.05)。模型组在位和异位内膜CLEC5A m RNA水平高于假手术组子宫内膜(P<0.05),模型组在位内膜IL-1βm RNA水平显著高于假手术组子宫内膜(P<0.05)。布洛芬组、针灸组、中药组和针药组异位内膜CLEC5A m RNA水平低于模型组(P<0.05);中药组异位内膜NLRP3、IL-1βm RNA水平低于模型组(P<0.05)。结论针药并用可能通过下调在位及异位内膜组织中CLEC5A m RNA及蛋白表达,调节NLRP3、IL-1β蛋白表达水平,缩小异位囊肿体积,提高痛阈,进而缓解大鼠子宫内膜异位症疼痛。展开更多
Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and ta...Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.展开更多
Traditional Chinese medicine(TCM)serves as a treasure trove of ancient knowledge,holding a crucial position in the medical field.However,the exploration of TCM's extensive information has been hindered by challeng...Traditional Chinese medicine(TCM)serves as a treasure trove of ancient knowledge,holding a crucial position in the medical field.However,the exploration of TCM's extensive information has been hindered by challenges related to data standardization,completeness,and accuracy,primarily due to the decen-tralized distribution of TCM resources.To address these issues,we developed a platform for TCM knowledge discovery(TCMKD,https://cbcb.cdutcm.edu.cn/TCMKD/).Seven types of data,including syndromes,formulas,Chinese patent drugs(CPDs),Chinese medicinal materials(CMMs),ingredients,targets,and diseases,were manually proofread and consolidated within TCMKD.To strengthen the integration of TCM with modern medicine,TCMKD employs analytical methods such as TCM data mining,enrichment analysis,and network localization and separation.These tools help elucidate the molecular-level commonalities between TCM and contemporary scientific insights.In addition to its analytical capabilities,a quick question and answer(Q&A)system is also embedded within TCMKD to query the database efficiently,thereby improving the interactivity of the platform.The platform also provides a TCM text annotation tool,offering a simple and efficient method for TCM text mining.Overall,TCMKD not only has the potential to become a pivotal repository for TCM,delving into the pharmaco-logical foundations of TCM treatments,but its flexible embedded tools and algorithms can also be applied to the study of other traditional medical systems,extending beyond just TCM.展开更多
文摘目的了解国内外中医师承发展历程、研究热点和新兴趋势。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science(WOS)、Embase、Cochrane Library 2003年1月1日-2023年12月8日中医师承研究文献,使用NoteExpress3.9软件纳入文献,使用Excel2021统计文献发表时间和载文期刊,使用VOSviewer1.6.19、CiteSpace6.2.R4软件对作者、机构、关键词进行可视化分析。结果本研究共纳入文献735篇。2003-2023年,国内外发文量呈波动上升趋势。该领域发文量较高的作者是潘华峰、史亚飞(7篇)。发文量最多的研究机构为北京中医药大学。关键词分析发现,人才培养和中医护理是中医师承研究的发展趋势。关键词共聚为4类,其主题分别为师承教育、院校教育、人才培养和中医传承。结论该领域研究团队间合作较少,机构间合作以同地域或邻近地域为主。中医师承的高质量发展可从教学模式改良、师承制度完善、学术思想传承3个方面进行。
文摘目的:基于乙二醛酶-1(GLO-1)/晚期糖基化终末产物(AGE)/晚期糖基化终末产物受体(RAGE)通路探讨糖痹康干膏防治2型糖尿病周围神经病变(DPN)的作用机制。方法:56只SD大鼠随机选取8只为正常组,其余48只大鼠予高脂饲料喂养联合腹腔注射链脲佐菌素(STZ)诱导2型糖尿病(T2DM)模型,按血糖将大鼠随机分为模型组、唐林组(13.5 mg·kg^(-1))、二甲双胍组(135 mg·kg^(-1))和糖痹康干膏低、中、高剂量组(3、6、12 g·kg^(-1))。干预第4周模型组机械痛痛阈下降则DPN造模成功。每4周测定大鼠的空腹血糖、体质量、机械痛痛阈。干预16周,苏木素-伊红(HE)染色法观察坐骨神经病理形态,免疫组化法检测坐骨神经RAGE、AGE、蛋白激酶C(PKC)、胶原蛋白(COL)表达,实时荧光定量聚合酶链式反应(Real-time PCR)检测坐骨神经RAGE、PKC、Toll样受体(TLR)、COL、GLO-1 m RNA表达。酶联免疫吸附测定法(ELISA)检测大鼠血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、肌酐(CREA)、尿素(UREA)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)-α含量。结果:与正常组比较,模型组空腹血糖升高(P<0.01),体质量及机械痛痛阈降低(P<0.01),血清AST、ALT、CREA、UREA、IL-6、TNF-α升高(P<0.01),坐骨神经RAGE、AGE、PKC表达升高(P<0.01),COL表达降低(P<0.01),TLR、RAGE、PKC m RNA表达升高(P<0.01),COL、GLO-1 m RNA表达降低(P<0.01),坐骨神经形态不规则、轴索形态改变、髓鞘变性。与模型组比较,糖痹康干膏高剂量组各时间,中剂量组给药第4、16周空腹血糖降低(P<0.05,P<0.01);糖痹康干膏各剂量组体质量无明显变化;糖痹康干膏各剂量组在给药后不同时间出现痛阈升高(P<0.05,P<0.01);各剂量组血清IL-6、TNF-α含量下降(P<0.05,P<0.01);糖痹康干膏各剂量组坐骨神经中RAGE、AGE、PKC表达降低(P<0.01),COL表达升高(P<0.01),TLR、RAGE、PKC m RNA表达降低(P<0.01),GLO-1 m RNA表达升高(P<0.05,P<0.01),低、高剂量组COL m RNA表达升高(P<0.01),糖痹康干膏各剂量组病理表现均较模型组病变程度轻。结论:糖痹康干膏具有明显改善DPN作用,其机制可能与调控GLO-1/AGE/RAGE通路作用有关。
文摘目的借助文献计量学方法可视化分析茯苓研究现状和热点,为科研及临床提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、Web of Science核心集、PubMed 2004年1月1日-2023年9月30日收录的茯苓研究文献。采用NoteExpress3.6.0.9155软件去重,采用Excel2016、CiteSpace6.2.R4和VOSviewer1.6.18.0软件分析年发文量、机构、来源期刊、作者及关键词,并进行可视化展示。结果纳入3861篇中文文献和477篇英文文献,年发文量总体呈上升趋势。中、英文文献发文较多的机构分别为江苏康缘药业股份有限公司和Chinese Academy of Sciences,发文较多的作者分别为王振中和Chen Lin,发文较多的期刊分别为《中草药》和Journal of Ethnopharmacology。高频关键词包括子宫肌瘤、临床疗效、polysaccharide和antioxidant activity等;得到20个聚类与36个突现关键词。结论该领域研究热点集中在茯苓的药理成分及作用机制、临床应用研究和数据挖掘等方面。
文摘目的观察针药并用对子宫内膜异位症疼痛大鼠CLEC5A、NLRP3和IL-1β表达的影响,探讨针药并用缓解子宫内膜异位症疼痛的作用机制。方法从48只大鼠随机选取8只进行假手术作为假手术组,剩余40只进行子宫内膜异位症造模,模型建立后根据异位囊肿总体积再区组随机分为模型组、布洛芬组、针灸组、中药组和针药组,每组8只。假手术组、模型组固定并给予等量0.9%生理盐水灌胃,布洛芬组固定并给予布洛芬和0.9%生理盐水混悬液灌胃,针灸组给于固定针灸干预,中药组固定并给予加味没竭片和0.9%生理盐水混悬液灌胃,针药组给予固定针灸和加味没竭片0.9%生理盐水混悬液灌胃。造模后和干预后测量并计算子宫内膜异位症大鼠异位囊肿体积,并测量6组大鼠痛阈。干预后检测6组内膜组织C型凝集素结构域家族5成员A(C-type lectin domain family 5 member A,CLEC5A)、NLR家族Pyrin域蛋白3(NOD-like receptor family pyrin domain containing protein 3,NLRP3)、白细胞介素-1β(interleukin 1β,IL-1β)蛋白和m RNA表达水平。结果针灸组、针药组干预后异位囊肿体积减少值和痛阈增加值均优于模型组(P<0.05)。模型组在位及异位内膜组织中CLEC5A、NLRP3、IL-1β蛋白表达水平高于正常子宫内膜组织(P<0.05)。针灸组、针药组在位及异位内膜组织中CLEC5A和NLRP3蛋白表达水平及异位内膜组织中IL-1β蛋白表达水平低于模型组(P<0.05),针灸组在位内膜IL-1β表达显著低于模型组(P<0.05)。针药组在位内膜组织CLEC5A蛋白表达水平低于布洛芬组和中药组(P<0.05),NLRP3蛋白表达水平低于布洛芬组(P<0.05);异位内膜组织CLEC5A蛋白表达水平低于针灸组、布洛芬组和中药组(P<0.05),NLRP3蛋白表达水平低于布洛芬组和中药组(P<0.05),IL-1β蛋白表达水平显著低于布洛芬组(P<0.05)。模型组在位和异位内膜CLEC5A m RNA水平高于假手术组子宫内膜(P<0.05),模型组在位内膜IL-1βm RNA水平显著高于假手术组子宫内膜(P<0.05)。布洛芬组、针灸组、中药组和针药组异位内膜CLEC5A m RNA水平低于模型组(P<0.05);中药组异位内膜NLRP3、IL-1βm RNA水平低于模型组(P<0.05)。结论针药并用可能通过下调在位及异位内膜组织中CLEC5A m RNA及蛋白表达,调节NLRP3、IL-1β蛋白表达水平,缩小异位囊肿体积,提高痛阈,进而缓解大鼠子宫内膜异位症疼痛。
基金Science and Technology strategic cooperation Programs of Luzhou Municipal People’s Government and Southwest Medical University (2019LZXNYD-P01DUAN)National Key R&D Program of China (2024YFC3505400)Regional Key R&D Program of Ningxia Hui Autonomous Region (2024BEG01003)。
文摘Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.
基金supported by Natural Science Foundation of Sichuan,China(Grant No.:2024ZDZX0019).
文摘Traditional Chinese medicine(TCM)serves as a treasure trove of ancient knowledge,holding a crucial position in the medical field.However,the exploration of TCM's extensive information has been hindered by challenges related to data standardization,completeness,and accuracy,primarily due to the decen-tralized distribution of TCM resources.To address these issues,we developed a platform for TCM knowledge discovery(TCMKD,https://cbcb.cdutcm.edu.cn/TCMKD/).Seven types of data,including syndromes,formulas,Chinese patent drugs(CPDs),Chinese medicinal materials(CMMs),ingredients,targets,and diseases,were manually proofread and consolidated within TCMKD.To strengthen the integration of TCM with modern medicine,TCMKD employs analytical methods such as TCM data mining,enrichment analysis,and network localization and separation.These tools help elucidate the molecular-level commonalities between TCM and contemporary scientific insights.In addition to its analytical capabilities,a quick question and answer(Q&A)system is also embedded within TCMKD to query the database efficiently,thereby improving the interactivity of the platform.The platform also provides a TCM text annotation tool,offering a simple and efficient method for TCM text mining.Overall,TCMKD not only has the potential to become a pivotal repository for TCM,delving into the pharmaco-logical foundations of TCM treatments,but its flexible embedded tools and algorithms can also be applied to the study of other traditional medical systems,extending beyond just TCM.
