INTRODUCTION,Drug addiction is a chronic and recurrent encephalopathy characterised by impulsive behaviour,spiritual cravings,psychological distortion and physical damage!'According to the role of molecular biolog...INTRODUCTION,Drug addiction is a chronic and recurrent encephalopathy characterised by impulsive behaviour,spiritual cravings,psychological distortion and physical damage!'According to the role of molecular biology mechanisms on the central nervous system,addictive substances can be classified as inhibitors(eg,opioids,etc),stimulants(eg,methamphetamine(MA),nicotine,cocaine,etc)and hallucinogens(eg,cannabis,etc).As published by the World Drug Report 2022,over284million individualsaged 15-64 worldwide have reportedly abused drugs in the past 12 months,emphasising the international challenge of effective detox treatment.展开更多
文摘目的分析甘肃省兰州市接受美沙酮维持治疗(MMT)人员感染丙型肝炎病毒(HCV)后肝纤维化与饮茶的关系,为该人群科学健康管理提供依据。方法 2017年5月随机抽取兰州市3个美沙酮维持治疗门诊,共调查HCV感染者157例,抽血检测血小板、天冬氨酸氨基转移酶和丙氨酸转氨酶;采用天冬氨酸氨基转移酶(AST)和血小板(PLT)比率指数(APRI)评分法预测肝纤维化;采用EPI DATA 3.1双录入建立数据库,使用SPSS 20.0软件统计分析数据。结果157例HCV感染者中饮茶者118例、饮茶率75.2%,肝纤维化者32例、肝纤维化率20.4%;多元Logistic回归结果显示,饮茶对肝纤维化具有一定的保护作用(OR=0.32,95%CI:0.12~0.86),喝花茶对肝纤维化的保护作用更加明显(OR=0.29,95%CI:0.10~0.86);与不饮茶者相比,每天喝2杯茶具有较低的肝纤维化风险(OR=0.25,95%CI:0.08~0.77),且经常或总是饮茶者发生丙型肝炎纤维化的风险也较低(OR=0.31,95%CI:0.12~0.82)。结论在接受美沙酮维持治疗的HCV感染者中,饮茶对丙型肝炎引起的肝纤维化具有保护作用。
基金supported by National Natural Science Foundation of China(61971451,U22A20303)Innovative Province Special Construction Foundation of Hunan Province(2019SK2131)+1 种基金the Science and Technology Innovation Program of Hunan Province(2021RC4016)Clinical Research Center for Medical Imaging in Hunan Province in China(2020SK4001).
文摘INTRODUCTION,Drug addiction is a chronic and recurrent encephalopathy characterised by impulsive behaviour,spiritual cravings,psychological distortion and physical damage!'According to the role of molecular biology mechanisms on the central nervous system,addictive substances can be classified as inhibitors(eg,opioids,etc),stimulants(eg,methamphetamine(MA),nicotine,cocaine,etc)and hallucinogens(eg,cannabis,etc).As published by the World Drug Report 2022,over284million individualsaged 15-64 worldwide have reportedly abused drugs in the past 12 months,emphasising the international challenge of effective detox treatment.
