目的 探讨孕妇孕晚期膳食酸负荷与婴儿体质指数Z评分(body mass index for age Z-score, BMIZ)轨迹的关系。方法 于2010年9月—2011年11月招募广州市468名孕晚期妇女为研究对象,孕妇分娩后随访其子代至1岁。孕妇于孕晚期完成基本情况问...目的 探讨孕妇孕晚期膳食酸负荷与婴儿体质指数Z评分(body mass index for age Z-score, BMIZ)轨迹的关系。方法 于2010年9月—2011年11月招募广州市468名孕晚期妇女为研究对象,孕妇分娩后随访其子代至1岁。孕妇于孕晚期完成基本情况问卷和连续3天24小时膳食回顾调查,于分娩后完成分娩情况及胎儿健康状况问卷调查。孕晚期膳食酸负荷采用潜在肾脏酸负荷(potential renal acid load, PRAL)、内源性酸净产生量(net endogenous acid production, NEAP)和动物蛋白与钾的比率(A∶K比率)进行计算,并根据各指标的四分位数进行分组。前瞻性追踪调查婴儿出生、1月龄、3月龄、6月龄以及1岁时的体重和身长,计算其BMIZ并采用潜类别增长模型(latent class growth model, LCGM)分析婴儿BMIZ轨迹。采用多元Logistic回归分析孕晚期膳食酸负荷与婴儿BMIZ轨迹的关系。结果 孕晚期PRAL[M(P25,P75)]为28.02(21.88,36.51)mEq/d, NEAP和A∶K比率(χ±s)为(81.58±15.41)mEq/d和22.62±6.80。膳食酸负荷与蔬菜、水果和豆类的摄入量呈显著负相关,与蛋类、禽肉、畜肉和海鲜类的摄入量呈显著正相关(P<0.01)。根据潜类别增长模型,识别出3类婴儿BMIZ轨迹组:较慢生长组(n=52)、适宜生长组(n=307)和较快生长组(n=54)。其中,较快生长组的婴儿其母亲的孕晚期NEAP低于另2个轨迹组(P<0.05)。多元Logistic回归分析显示,与最低四分位数组相比,孕晚期NEAP (OR=4.03,95%CI 1.01~16.14)和A∶K比率(OR=4.04,95%CI 1.30~12.59)处于最高四分位数组的孕妇其后代更有可能出现较慢生长轨迹。结论 孕晚期膳食酸负荷较高,尤其是NEAP和A∶K比率水平较高容易使婴儿出现较慢生长模式。展开更多
Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between ...Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America(USA).Methods To clarify the relationship between the NHHR and stroke risk,this study used a multivariable logistic regression model and a restricted cubic spline(RCS)model to investigate the association between the NHHR and stroke,and data from the National Health and Nutrition Examination Survey(NHANES)from 2005 to 2018.Subgroup and sensitivity analyses were conducted to test the robustness of the results.Results This study included 29,928 adult participants,of which 1,165 participants had a history of stroke.Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke(OR 1.24,95%CI:1.03-1.50,P=0.026).Compared with the lowest reference group of NHHR,participants in the second,third,and fourth quartile had a significantly increased risk of stroke after full adjustments(OR:1.35,95%CI:1.08-1.69)(OR:1.83,95%CI:1.42-2.36)(OR:2.04,95%CI:1.50-2.79).In the total population,a nonlinear dose-response relationship was observed between the NHHR and stroke risk(P non-linearity=0.002).This association remained significant in several subgroup analyses.Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.Conclusion Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke,potentially serving as a novel predictive factor for stroke.Timely intervention and management of the NHHR may effectively mitigate stroke occurrence.Prospective studies are required to validate this association and further explore the underlying biological mechanisms.展开更多
目的了解2002—2015年我国≥60岁老年人高血压-糖尿病共病流行变化趋势,分析膳食炎症指数(dietary inflammatory index,DII)和体质量指数(body mass index,BMI)对老年人高血压-糖尿病共病患病风险的影响,在膳食和体重管理指导层面为高血...目的了解2002—2015年我国≥60岁老年人高血压-糖尿病共病流行变化趋势,分析膳食炎症指数(dietary inflammatory index,DII)和体质量指数(body mass index,BMI)对老年人高血压-糖尿病共病患病风险的影响,在膳食和体重管理指导层面为高血压-糖尿病共病的预防及控制提供科学依据。方法利用“中国居民营养与健康状况调查/监测”2002年、2010—2012年和2015年收集的≥60岁老年人相关数据。对数据进行复杂抽样加权处理后,采用SURVEYFREQ过程计算高血压-糖尿病共病患病率,采用SURVEYLOGISTIC回归模型分析DII、BMI与高血压-糖尿病共病之间的关联。结果2002—2015年我国老年人高血压-糖尿病共病患病率呈上升趋势,由2002年的6.35%上升至2015年的11.28%。比较分析2015年膳食调查对象中不同DII膳食组的食物摄入量发现,抗炎饮食组烹调油、烹调盐摄入量低于各促炎饮食组,而其他食物摄入量均高于各促炎饮食组,差异有统计学意义(P<0.01)。多因素logistic回归模型分析结果显示,调整混杂因素后,当DII、BMI作为连续变量进行分析时,DII(OR=1.10,95%CI:1.04~1.16)、BMI(OR=1.18,95%CI:1.14~1.21)均与高血压-糖尿病共病患病风险之间呈正相关。与抗炎饮食组相比,促炎饮食组OR值(95%CI)为1.49(1.18~1.89),低、高促炎饮食组分别为1.41(1.08~1.83)、1.60(1.21~2.10)。与非肥胖组相比,肥胖组OR值(95%CI)为3.09(2.48~3.86)。促炎饮食+非肥胖、抗炎饮食+肥胖、促炎饮食+肥胖患高血压-糖尿病共病的风险分别是抗炎饮食+非肥胖的1.42倍(95%CI:1.09~1.86)、2.66倍(95%CI:1.66~4.25)、4.90倍(95%CI:3.62~6.64)。结论促炎饮食和肥胖与我国老年人高血压-糖尿病共病患病风险增加相关,在高血压-糖尿病共病的预防管理中,应将促炎饮食、肥胖人群作为重点关注对象,进行知识普及、定期监测。展开更多
文摘Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America(USA).Methods To clarify the relationship between the NHHR and stroke risk,this study used a multivariable logistic regression model and a restricted cubic spline(RCS)model to investigate the association between the NHHR and stroke,and data from the National Health and Nutrition Examination Survey(NHANES)from 2005 to 2018.Subgroup and sensitivity analyses were conducted to test the robustness of the results.Results This study included 29,928 adult participants,of which 1,165 participants had a history of stroke.Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke(OR 1.24,95%CI:1.03-1.50,P=0.026).Compared with the lowest reference group of NHHR,participants in the second,third,and fourth quartile had a significantly increased risk of stroke after full adjustments(OR:1.35,95%CI:1.08-1.69)(OR:1.83,95%CI:1.42-2.36)(OR:2.04,95%CI:1.50-2.79).In the total population,a nonlinear dose-response relationship was observed between the NHHR and stroke risk(P non-linearity=0.002).This association remained significant in several subgroup analyses.Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.Conclusion Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke,potentially serving as a novel predictive factor for stroke.Timely intervention and management of the NHHR may effectively mitigate stroke occurrence.Prospective studies are required to validate this association and further explore the underlying biological mechanisms.
文摘目的了解2002—2015年我国≥60岁老年人高血压-糖尿病共病流行变化趋势,分析膳食炎症指数(dietary inflammatory index,DII)和体质量指数(body mass index,BMI)对老年人高血压-糖尿病共病患病风险的影响,在膳食和体重管理指导层面为高血压-糖尿病共病的预防及控制提供科学依据。方法利用“中国居民营养与健康状况调查/监测”2002年、2010—2012年和2015年收集的≥60岁老年人相关数据。对数据进行复杂抽样加权处理后,采用SURVEYFREQ过程计算高血压-糖尿病共病患病率,采用SURVEYLOGISTIC回归模型分析DII、BMI与高血压-糖尿病共病之间的关联。结果2002—2015年我国老年人高血压-糖尿病共病患病率呈上升趋势,由2002年的6.35%上升至2015年的11.28%。比较分析2015年膳食调查对象中不同DII膳食组的食物摄入量发现,抗炎饮食组烹调油、烹调盐摄入量低于各促炎饮食组,而其他食物摄入量均高于各促炎饮食组,差异有统计学意义(P<0.01)。多因素logistic回归模型分析结果显示,调整混杂因素后,当DII、BMI作为连续变量进行分析时,DII(OR=1.10,95%CI:1.04~1.16)、BMI(OR=1.18,95%CI:1.14~1.21)均与高血压-糖尿病共病患病风险之间呈正相关。与抗炎饮食组相比,促炎饮食组OR值(95%CI)为1.49(1.18~1.89),低、高促炎饮食组分别为1.41(1.08~1.83)、1.60(1.21~2.10)。与非肥胖组相比,肥胖组OR值(95%CI)为3.09(2.48~3.86)。促炎饮食+非肥胖、抗炎饮食+肥胖、促炎饮食+肥胖患高血压-糖尿病共病的风险分别是抗炎饮食+非肥胖的1.42倍(95%CI:1.09~1.86)、2.66倍(95%CI:1.66~4.25)、4.90倍(95%CI:3.62~6.64)。结论促炎饮食和肥胖与我国老年人高血压-糖尿病共病患病风险增加相关,在高血压-糖尿病共病的预防管理中,应将促炎饮食、肥胖人群作为重点关注对象,进行知识普及、定期监测。
