As the first barrier of the body,the skin is inevitably damaged by radiation during clinical radiotherapy(typically administered at 2-3 Gy per session,for a total of approximately 50-80 Gy to eradicate tumors)or nucle...As the first barrier of the body,the skin is inevitably damaged by radiation during clinical radiotherapy(typically administered at 2-3 Gy per session,for a total of approximately 50-80 Gy to eradicate tumors)or nuclear accidents.Currently,the primary clinical methods for protecting against radiation are limited,and some have serious side effects.1,2-Propanediol(PPD)is a low-toxicity small-molecule compound that is typically used as a humectant in drug solvents,food additives,pharmaceutical excipients,cosmetics,and electronic cigarettes.Furthermore,PPD can also be used as a co-solvent to enhance drug penetration into the skin.In 1980,both PPD and cysteine were first described to protect against radiation[1].Correspondingly,in 2019,it was reported that PPD pretreatment effectively promoted hematopoietic stem cell recovery following irradiation[2].These studies suggest that PPD may be an effective radioprotective agent;however,its protective effect against radiation-induced skin damage has not been reported.In the present study,the protective effects of PPD against X-ray-induced radiation in human epidermal cells were assessed.展开更多
文摘As the first barrier of the body,the skin is inevitably damaged by radiation during clinical radiotherapy(typically administered at 2-3 Gy per session,for a total of approximately 50-80 Gy to eradicate tumors)or nuclear accidents.Currently,the primary clinical methods for protecting against radiation are limited,and some have serious side effects.1,2-Propanediol(PPD)is a low-toxicity small-molecule compound that is typically used as a humectant in drug solvents,food additives,pharmaceutical excipients,cosmetics,and electronic cigarettes.Furthermore,PPD can also be used as a co-solvent to enhance drug penetration into the skin.In 1980,both PPD and cysteine were first described to protect against radiation[1].Correspondingly,in 2019,it was reported that PPD pretreatment effectively promoted hematopoietic stem cell recovery following irradiation[2].These studies suggest that PPD may be an effective radioprotective agent;however,its protective effect against radiation-induced skin damage has not been reported.In the present study,the protective effects of PPD against X-ray-induced radiation in human epidermal cells were assessed.
