This paper reported about a polymer of acyl imine synthesized by 3-morpholinone(M)and e-caprolactone(CL)with zinc powder as catalyst.The influence of reaction temperature,reaction time and monomer ratio on the copolym...This paper reported about a polymer of acyl imine synthesized by 3-morpholinone(M)and e-caprolactone(CL)with zinc powder as catalyst.The influence of reaction temperature,reaction time and monomer ratio on the copolymerization reaction was studied.Investigation of monomer reaction ratio and differential scanning calorimeter(DSC)indicated that the copolymer poly(3-morpholinone-e-caprolactone)was a block copolymer,solubility in water,degradation characteristics in vitro and controlled release of 5-FU was also studied.The results showed the hydrophilicity of the copolymer increased with the increasing of M content in the copolymer.With the enhancement of hydrophilicity its degradation rate and drug releasing rate increased as well.展开更多
基金the National Key Basic Research Program of China(973 Program)(G2003CB114403)
文摘This paper reported about a polymer of acyl imine synthesized by 3-morpholinone(M)and e-caprolactone(CL)with zinc powder as catalyst.The influence of reaction temperature,reaction time and monomer ratio on the copolymerization reaction was studied.Investigation of monomer reaction ratio and differential scanning calorimeter(DSC)indicated that the copolymer poly(3-morpholinone-e-caprolactone)was a block copolymer,solubility in water,degradation characteristics in vitro and controlled release of 5-FU was also studied.The results showed the hydrophilicity of the copolymer increased with the increasing of M content in the copolymer.With the enhancement of hydrophilicity its degradation rate and drug releasing rate increased as well.
