1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱(DPPC,1)不仅可作为药用辅料,还可作为外源性肺表面活性剂,治疗新生儿呼吸窘迫综合征(NRDS)。甘油磷脂酰胆碱(GPC,2)在DCM中,在4-二甲氨基吡啶(DMAP)和二环己基碳二亚胺(DCC)的作用下,与棕榈酸(PA,3)...1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱(DPPC,1)不仅可作为药用辅料,还可作为外源性肺表面活性剂,治疗新生儿呼吸窘迫综合征(NRDS)。甘油磷脂酰胆碱(GPC,2)在DCM中,在4-二甲氨基吡啶(DMAP)和二环己基碳二亚胺(DCC)的作用下,与棕榈酸(PA,3)反应得DPPC。但发现产生了某一杂质,严重影响产物的纯化。分离、纯化后经MS和1 H NMR确证,该杂质为1,1'-亚甲基双(4-二甲氨基吡啶鎓)双氯化物。把反应溶剂改为乙腈,并将DMAP投料时物质的量比例从3降低至1,目标产物1的收率由33.20%提升至49.18%,纯度99.92%。展开更多
A method of preparation of ultrallne CaCO3 particles in ordered systems, as in vesicle and Ancroemulsion, consisting of egg yolk phospholipid and water has been introduced. The size of CaCO3 grain was controlled by th...A method of preparation of ultrallne CaCO3 particles in ordered systems, as in vesicle and Ancroemulsion, consisting of egg yolk phospholipid and water has been introduced. The size of CaCO3 grain was controlled by the content of egg yolk phospholipid and size of liposoms in the systems. It was found by experiment that vaterite is formed inside the doublle layer vesicles but caJcite is formed outside of the vesicles. A discussed of the cause of this difference has been giYen.展开更多
文摘1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱(DPPC,1)不仅可作为药用辅料,还可作为外源性肺表面活性剂,治疗新生儿呼吸窘迫综合征(NRDS)。甘油磷脂酰胆碱(GPC,2)在DCM中,在4-二甲氨基吡啶(DMAP)和二环己基碳二亚胺(DCC)的作用下,与棕榈酸(PA,3)反应得DPPC。但发现产生了某一杂质,严重影响产物的纯化。分离、纯化后经MS和1 H NMR确证,该杂质为1,1'-亚甲基双(4-二甲氨基吡啶鎓)双氯化物。把反应溶剂改为乙腈,并将DMAP投料时物质的量比例从3降低至1,目标产物1的收率由33.20%提升至49.18%,纯度99.92%。
文摘A method of preparation of ultrallne CaCO3 particles in ordered systems, as in vesicle and Ancroemulsion, consisting of egg yolk phospholipid and water has been introduced. The size of CaCO3 grain was controlled by the content of egg yolk phospholipid and size of liposoms in the systems. It was found by experiment that vaterite is formed inside the doublle layer vesicles but caJcite is formed outside of the vesicles. A discussed of the cause of this difference has been giYen.
