Enhancing the vibration resistance of micro-electro-mechanical systems(MEMS)resonators in complex environments is a critical issue that urgently needs to be addressed.This paper presents a chip-scale locally resonant ...Enhancing the vibration resistance of micro-electro-mechanical systems(MEMS)resonators in complex environments is a critical issue that urgently needs to be addressed.This paper presents a chip-scale locally resonant phononic crystal(LRPnC)plate based on a folded helical beam structure.Through finite element simulation and theoretical analysis,the bandgap characteristics and vibration suppression mechanisms of this structure were thoroughly investigated.The results show that the structure exhibits a complete bandgap in the frequency range of 9.867-14.605 kHz,and the bandgap can be effectively tuned by adjusting the structural parameters.Based on this,the influence of the number of unit cell layers on the vibration reduction performance was further studied,and a finite periodic LRPnC plate was constructed.Numerical studies have shown that the LRPnC plate can achieve more than-30 dB of vibration attenuation within the bandgap and effectively suppress y-direction coupling vibrations caused by x-direction propagating waves.In addition,its chip-scale size and planar structure design provide new ideas and methods for the engineering application of phononic crystal technology in the field of MEMS vibration isolation.展开更多
Objective To evaluate the efficacy and safety of third-generation epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKIs)in combination with radiotherapy(RT)for patients with advanced non-small cell lun...Objective To evaluate the efficacy and safety of third-generation epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKIs)in combination with radiotherapy(RT)for patients with advanced non-small cell lung cancer(NSCLC)harboring typical EGFR mutations.Methods Patients who received treatment with third-generation EGFR-TKIs alone or in combination with RT were retrospectively enrolled at a single center.The primary endpoint was progression-free survival(PFS).Differences in PFS between the two groups were assessed via the Kaplan–Meier method.Additionally,a subgroup analysis was conducted to further explore the effect of thoracic RT combined with EGFR-TKIs.Results This study included a total of 260 patients,among whom 81 patients received third-generation EGFR-TKIs and 179 patients received third-generation EGFR-TKIs plus RT.There was a significant difference in median PFS(mPFS)(13.0 versus 18.1 months,P=0.0003)between the two groups.Moreover,third-generation EGFR-TKIs plus thoracic RT significantly improved the mPFS(13.0 versus 23.7 months,P<0.0001).We observed that third-generation EGFR-TKIs plus RT increased the incidence of pneumonia,but all the cases were grade 1 or 2.Conclusion The addition of RT can delay the occurrence of acquired resistance to third-generation EGFR-TKIs,thereby significantly prolonging PFS in advanced NSCLC patients.RT for primary lung lesions exhibited a significant synergistic effect with EGFR-TKI treatment,and the adverse events of the combination therapy were acceptable.展开更多
Two-dimensional phononic crystal(PnC)slabs have shown advantages in enhancing the quality factors Q of piezoelectric laterally vibrating resonators(LVRs)through topology optimization.However,the narrow geometries of m...Two-dimensional phononic crystal(PnC)slabs have shown advantages in enhancing the quality factors Q of piezoelectric laterally vibrating resonators(LVRs)through topology optimization.However,the narrow geometries of most topology-optimized silicon–air 2D PnC slabs face significant fabrication challenges owing to restricted etching precision,and the anisotropic nature of silicon is frequently overlooked.To address these issues,this study employs the finite element method with appropriate discretization numbers and the genetic algorithm to optimize the structures and geometries of 2D silicon–air PnC slabs.The optimized square-lattice PnC slabs,featuring a rounded-cross structure oriented along the`110e directions of silicon,achieve an impressive relative bandgap(RBG)width of 82.2%for in-plane modes.When further tilted by 15° from the (100) directions within the(001)plane,the optimal RBG width is expanded to 91.4%.We fabricate and characterize thin-film piezoelectric-on-silicon LVRs,with or without optimized 2D PnC slabs.The presence of PnC slabs around anchors increases the series and parallel quality factors Q_(s) and Q_(p) from 2240 to 7118 and from 2237 to 7501,respectively,with the PnC slabs oriented along the`110e directions of silicon.展开更多
Recent studies have increasingly identified extended main sequence turn-off(e MSTO)phenomena in Galactic open clusters,yet the number of such clusters with sufficient spectroscopic information for member stars remains...Recent studies have increasingly identified extended main sequence turn-off(e MSTO)phenomena in Galactic open clusters,yet the number of such clusters with sufficient spectroscopic information for member stars remains limited.Unlike most studies that rely on fitting isochrones based on color–magnitude diagram(CMD)morphology to account for varying rotational velocities,our approach leverages LAMOST spectral data to compute actual rotational velocity distributions for confirmed cluster members,along with parameters such as metallicity,differential extinction,and rotational inclination,to utilize PARSEC isochrones for fitting the cluster CMDs.We systematically surveyed all known Galactic open clusters and selected 12 clusters where rotational velocity distributions could be reliably calculated for detailed fitting.Our results successfully reproduced the eMSTO phenomenon observed in these clusters.For the majority of clusters,considering only differential extinction and variations in rotational velocity adequately explains the position and morphology of the MSTO.For some intermediate-age clusters,incorporating rotational inclination additionally accounts for the broadening of the MSTO.This study underscores the importance of spectroscopic data in understanding eMSTO phenomena and provides a probable explanation for interpreting the combined effects of differential extinction,rotation,and inclination on the CMDs of Galactic open clusters.展开更多
In response to the ultrasonic scalpels with the vibrational modal coupling which leads to a decrease in efficiency,an ultrasonic scalpel based on fusiform phononic crystals(PnCs)is proposed.An accurate theoretical mod...In response to the ultrasonic scalpels with the vibrational modal coupling which leads to a decrease in efficiency,an ultrasonic scalpel based on fusiform phononic crystals(PnCs)is proposed.An accurate theoretical model is constructed,which is mainly composed of electromechanical equivalent circuit models to analyze the frequency response function and the frequency response curves of the admittance.Bragg band gaps exist in the fusiform PnCs owing to the periodic constraint,which can suppress the corresponding vibrational modes.The vibration characteristics(vibration mode,frequency,and displacement distribution)of the ultrasonic scalpel are analyzed,and the validity of the electromechanical equivalent circuit method is verified.The results indicate that other vibration modes near the working frequency can be isolated.In addition,blades based on fusiform PnCs have a function akin to that of the horn,which enables displacement amplification.展开更多
A new method based on phononic crystals is presented to detect the concentration of heavy water(D_(2)O)in an H_(2)O-D_(2)O mixture.Results have been obtained and analyzed in the concentration range of 0%-10%and 90%-10...A new method based on phononic crystals is presented to detect the concentration of heavy water(D_(2)O)in an H_(2)O-D_(2)O mixture.Results have been obtained and analyzed in the concentration range of 0%-10%and 90%-100%D_(2)O.A proposed structure of tungsten scatterers in an aluminum host is studied.In order to detect the target material,a cavity region is considered as a sound wave resonator in which the target material with different concentrations of D_(2)O is embedded.By changing the concentration of D_(2)O in the H_(2)O-D_(2)O mixture,the resonance frequency undergoes a frequency shift.Each 1%change in D_(2)O concentration in the H_(2)O-D_(2)O mixture causes a frequency change of about 120 Hz.The finite element method is used as the numerical method to calculate and analyze the natural frequencies and transmission spectra of the proposed sensor.The performance evaluation index shows a high Q factor up to 1475758 and a high sensitivity up to 13075,which are acceptable values for sensing purposes.The other figures of merit related to the detection performance also indicate high-quality performance of the designed sensor.展开更多
Phononic crystals,as artificial composite materials,have sparked significant interest due to their novel characteristics that emerge upon the introduction of nonlinearity.Among these properties,second-harmonic feature...Phononic crystals,as artificial composite materials,have sparked significant interest due to their novel characteristics that emerge upon the introduction of nonlinearity.Among these properties,second-harmonic features exhibit potential applications in acoustic frequency conversion,non-reciprocal wave propagation,and non-destructive testing.Precisely manipulating the harmonic band structure presents a major challenge in the design of nonlinear phononic crystals.Traditional design approaches based on parameter adjustments to meet specific application requirements are inefficient and often yield suboptimal performance.Therefore,this paper develops a design methodology using Softmax logistic regression and multi-label classification learning to inversely design the material distribution of nonlinear phononic crystals by exploiting information from harmonic transmission spectra.The results demonstrate that the neural network-based inverse design method can effectively tailor nonlinear phononic crystals with desired functionalities.This work establishes a mapping relationship between the band structure and the material distribution within phononic crystals,providing valuable insights into the inverse design of metamaterials.展开更多
基金supported by National Natural Science Foundation of China(No.62271262).
文摘Enhancing the vibration resistance of micro-electro-mechanical systems(MEMS)resonators in complex environments is a critical issue that urgently needs to be addressed.This paper presents a chip-scale locally resonant phononic crystal(LRPnC)plate based on a folded helical beam structure.Through finite element simulation and theoretical analysis,the bandgap characteristics and vibration suppression mechanisms of this structure were thoroughly investigated.The results show that the structure exhibits a complete bandgap in the frequency range of 9.867-14.605 kHz,and the bandgap can be effectively tuned by adjusting the structural parameters.Based on this,the influence of the number of unit cell layers on the vibration reduction performance was further studied,and a finite periodic LRPnC plate was constructed.Numerical studies have shown that the LRPnC plate can achieve more than-30 dB of vibration attenuation within the bandgap and effectively suppress y-direction coupling vibrations caused by x-direction propagating waves.In addition,its chip-scale size and planar structure design provide new ideas and methods for the engineering application of phononic crystal technology in the field of MEMS vibration isolation.
文摘Objective To evaluate the efficacy and safety of third-generation epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKIs)in combination with radiotherapy(RT)for patients with advanced non-small cell lung cancer(NSCLC)harboring typical EGFR mutations.Methods Patients who received treatment with third-generation EGFR-TKIs alone or in combination with RT were retrospectively enrolled at a single center.The primary endpoint was progression-free survival(PFS).Differences in PFS between the two groups were assessed via the Kaplan–Meier method.Additionally,a subgroup analysis was conducted to further explore the effect of thoracic RT combined with EGFR-TKIs.Results This study included a total of 260 patients,among whom 81 patients received third-generation EGFR-TKIs and 179 patients received third-generation EGFR-TKIs plus RT.There was a significant difference in median PFS(mPFS)(13.0 versus 18.1 months,P=0.0003)between the two groups.Moreover,third-generation EGFR-TKIs plus thoracic RT significantly improved the mPFS(13.0 versus 23.7 months,P<0.0001).We observed that third-generation EGFR-TKIs plus RT increased the incidence of pneumonia,but all the cases were grade 1 or 2.Conclusion The addition of RT can delay the occurrence of acquired resistance to third-generation EGFR-TKIs,thereby significantly prolonging PFS in advanced NSCLC patients.RT for primary lung lesions exhibited a significant synergistic effect with EGFR-TKI treatment,and the adverse events of the combination therapy were acceptable.
基金supported by the National Natural Science Foundation of China(Grant No.52175552)the National Key RD Program of China(Grant Nos.2022YFB3205400 and 2022YFB3204300).
文摘Two-dimensional phononic crystal(PnC)slabs have shown advantages in enhancing the quality factors Q of piezoelectric laterally vibrating resonators(LVRs)through topology optimization.However,the narrow geometries of most topology-optimized silicon–air 2D PnC slabs face significant fabrication challenges owing to restricted etching precision,and the anisotropic nature of silicon is frequently overlooked.To address these issues,this study employs the finite element method with appropriate discretization numbers and the genetic algorithm to optimize the structures and geometries of 2D silicon–air PnC slabs.The optimized square-lattice PnC slabs,featuring a rounded-cross structure oriented along the`110e directions of silicon,achieve an impressive relative bandgap(RBG)width of 82.2%for in-plane modes.When further tilted by 15° from the (100) directions within the(001)plane,the optimal RBG width is expanded to 91.4%.We fabricate and characterize thin-film piezoelectric-on-silicon LVRs,with or without optimized 2D PnC slabs.The presence of PnC slabs around anchors increases the series and parallel quality factors Q_(s) and Q_(p) from 2240 to 7118 and from 2237 to 7501,respectively,with the PnC slabs oriented along the`110e directions of silicon.
基金supported by the National Natural Science Foundation of China,No.12261141689。
文摘Recent studies have increasingly identified extended main sequence turn-off(e MSTO)phenomena in Galactic open clusters,yet the number of such clusters with sufficient spectroscopic information for member stars remains limited.Unlike most studies that rely on fitting isochrones based on color–magnitude diagram(CMD)morphology to account for varying rotational velocities,our approach leverages LAMOST spectral data to compute actual rotational velocity distributions for confirmed cluster members,along with parameters such as metallicity,differential extinction,and rotational inclination,to utilize PARSEC isochrones for fitting the cluster CMDs.We systematically surveyed all known Galactic open clusters and selected 12 clusters where rotational velocity distributions could be reliably calculated for detailed fitting.Our results successfully reproduced the eMSTO phenomenon observed in these clusters.For the majority of clusters,considering only differential extinction and variations in rotational velocity adequately explains the position and morphology of the MSTO.For some intermediate-age clusters,incorporating rotational inclination additionally accounts for the broadening of the MSTO.This study underscores the importance of spectroscopic data in understanding eMSTO phenomena and provides a probable explanation for interpreting the combined effects of differential extinction,rotation,and inclination on the CMDs of Galactic open clusters.
基金supported by the National Natural Science Foundation of China(Grant Nos.62204112,12174240,and 11874253)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20220774).
文摘In response to the ultrasonic scalpels with the vibrational modal coupling which leads to a decrease in efficiency,an ultrasonic scalpel based on fusiform phononic crystals(PnCs)is proposed.An accurate theoretical model is constructed,which is mainly composed of electromechanical equivalent circuit models to analyze the frequency response function and the frequency response curves of the admittance.Bragg band gaps exist in the fusiform PnCs owing to the periodic constraint,which can suppress the corresponding vibrational modes.The vibration characteristics(vibration mode,frequency,and displacement distribution)of the ultrasonic scalpel are analyzed,and the validity of the electromechanical equivalent circuit method is verified.The results indicate that other vibration modes near the working frequency can be isolated.In addition,blades based on fusiform PnCs have a function akin to that of the horn,which enables displacement amplification.
文摘A new method based on phononic crystals is presented to detect the concentration of heavy water(D_(2)O)in an H_(2)O-D_(2)O mixture.Results have been obtained and analyzed in the concentration range of 0%-10%and 90%-100%D_(2)O.A proposed structure of tungsten scatterers in an aluminum host is studied.In order to detect the target material,a cavity region is considered as a sound wave resonator in which the target material with different concentrations of D_(2)O is embedded.By changing the concentration of D_(2)O in the H_(2)O-D_(2)O mixture,the resonance frequency undergoes a frequency shift.Each 1%change in D_(2)O concentration in the H_(2)O-D_(2)O mixture causes a frequency change of about 120 Hz.The finite element method is used as the numerical method to calculate and analyze the natural frequencies and transmission spectra of the proposed sensor.The performance evaluation index shows a high Q factor up to 1475758 and a high sensitivity up to 13075,which are acceptable values for sensing purposes.The other figures of merit related to the detection performance also indicate high-quality performance of the designed sensor.
基金supported by the National Key Research and Development Program of China(Grant No.2020YFA0211400)the State Key Program of the National Natural Science of China(Grant No.11834008)+2 种基金the National Natural Science Foundation of China(Grant Nos.12174192,12174188,and 11974176)the State Key Laboratory of Acoustics,Chinese Academy of Sciences(Grant No.SKLA202410)the Fund from the Key Laboratory of Underwater Acoustic Environment,Chinese Academy of Sciences(Grant No.SSHJ-KFKT-1701).
文摘Phononic crystals,as artificial composite materials,have sparked significant interest due to their novel characteristics that emerge upon the introduction of nonlinearity.Among these properties,second-harmonic features exhibit potential applications in acoustic frequency conversion,non-reciprocal wave propagation,and non-destructive testing.Precisely manipulating the harmonic band structure presents a major challenge in the design of nonlinear phononic crystals.Traditional design approaches based on parameter adjustments to meet specific application requirements are inefficient and often yield suboptimal performance.Therefore,this paper develops a design methodology using Softmax logistic regression and multi-label classification learning to inversely design the material distribution of nonlinear phononic crystals by exploiting information from harmonic transmission spectra.The results demonstrate that the neural network-based inverse design method can effectively tailor nonlinear phononic crystals with desired functionalities.This work establishes a mapping relationship between the band structure and the material distribution within phononic crystals,providing valuable insights into the inverse design of metamaterials.
