Curcumin is the main component of Curcuma longa,a traditional Chinese medicinal herb,with excellent antioxidant.Curcumin is easily decomposed under light and heat.In this study,to find stable antioxidants,6 curcumin a...Curcumin is the main component of Curcuma longa,a traditional Chinese medicinal herb,with excellent antioxidant.Curcumin is easily decomposed under light and heat.In this study,to find stable antioxidants,6 curcumin analogs(A1-6) were synthesized by coupling the appropriate aromatic aldehyde and cyclohexanon with HCl catalysis,and the free radical（DPPH） scavenging abilities of synthetic curcumin analogs were evaluated.The results showed that the free radical（DPPH） scavenging abilities of curcumin analogs（A2,A3 and A6） were promoted when hydroxyl or methoxyl groups were introduced in the ortho place of phenols,the compound with ortho dihydroxy groups showed the stronges free radical（DPPH） scavenging abilities among curcumin analogs with IC50 of 1.5 μM.展开更多
建立了虾中万古霉素和去甲万古霉素残留量的高效液相色谱-串联质谱(HPLC-MS/MS)检测方法。样品经0.1%甲酸-乙腈(9∶1,体积比)混合溶液提取,乙腈饱和的正己烷除脂,PCX结合Florisil固相萃取柱进行净化后,以乙腈和0.1%甲酸溶液为流动相,经C...建立了虾中万古霉素和去甲万古霉素残留量的高效液相色谱-串联质谱(HPLC-MS/MS)检测方法。样品经0.1%甲酸-乙腈(9∶1,体积比)混合溶液提取,乙腈饱和的正己烷除脂,PCX结合Florisil固相萃取柱进行净化后,以乙腈和0.1%甲酸溶液为流动相,经CAPCELL PAK MG-C18色谱柱分离后,采用高效液相色谱-串联质谱在多反应离子监测(MRM)模式进行测定,以双去氯万古霉素作为内标物,内标法定量。结果表明:万古霉素和去甲万古霉素在2~250 ng/m L范围内呈良好的线性关系,相关系数(r2)均大于0.99。在5,25,50μg/kg加标水平下,万古霉素和去甲万古霉素的平均回收率为87.2%~102%,相对标准偏差为1.3%~8.7%。方法的检出限(LOD)为2.0μg/kg,定量下限(LOQ)为5.0μg/kg。该方法灵敏、准确,重复性好,适用于虾类中万古霉素及去甲万古霉素残留量的测定。展开更多
Curcumin(N1),demethoxycurcumin(N2) and bisdemethoxycurcumin(N3) were isolated from the extract of Curcuma longa(turmeric),and curcumin derivatives(N11～N14) were synthesized.Curcuminoids and curcumin derivatives were ...Curcumin(N1),demethoxycurcumin(N2) and bisdemethoxycurcumin(N3) were isolated from the extract of Curcuma longa(turmeric),and curcumin derivatives(N11～N14) were synthesized.Curcuminoids and curcumin derivatives were evaluated in vitro for the aldose reductase inhibitory activity.The results showed that curcuminoids and curcumin derivatives with hydroxyl or carboxyl acid groups exerted inhibitory activities on aldose reductase,and curcuminoid(N1) and curcumin derivative compound(N13) exhibited potential inhibitory activities.展开更多
文摘Curcumin is the main component of Curcuma longa,a traditional Chinese medicinal herb,with excellent antioxidant.Curcumin is easily decomposed under light and heat.In this study,to find stable antioxidants,6 curcumin analogs(A1-6) were synthesized by coupling the appropriate aromatic aldehyde and cyclohexanon with HCl catalysis,and the free radical（DPPH） scavenging abilities of synthetic curcumin analogs were evaluated.The results showed that the free radical（DPPH） scavenging abilities of curcumin analogs（A2,A3 and A6） were promoted when hydroxyl or methoxyl groups were introduced in the ortho place of phenols,the compound with ortho dihydroxy groups showed the stronges free radical（DPPH） scavenging abilities among curcumin analogs with IC50 of 1.5 μM.
文摘建立了虾中万古霉素和去甲万古霉素残留量的高效液相色谱-串联质谱(HPLC-MS/MS)检测方法。样品经0.1%甲酸-乙腈(9∶1,体积比)混合溶液提取,乙腈饱和的正己烷除脂,PCX结合Florisil固相萃取柱进行净化后,以乙腈和0.1%甲酸溶液为流动相,经CAPCELL PAK MG-C18色谱柱分离后,采用高效液相色谱-串联质谱在多反应离子监测(MRM)模式进行测定,以双去氯万古霉素作为内标物,内标法定量。结果表明:万古霉素和去甲万古霉素在2~250 ng/m L范围内呈良好的线性关系,相关系数(r2)均大于0.99。在5,25,50μg/kg加标水平下,万古霉素和去甲万古霉素的平均回收率为87.2%~102%,相对标准偏差为1.3%~8.7%。方法的检出限(LOD)为2.0μg/kg,定量下限(LOQ)为5.0μg/kg。该方法灵敏、准确,重复性好,适用于虾类中万古霉素及去甲万古霉素残留量的测定。
文摘Curcumin(N1),demethoxycurcumin(N2) and bisdemethoxycurcumin(N3) were isolated from the extract of Curcuma longa(turmeric),and curcumin derivatives(N11～N14) were synthesized.Curcuminoids and curcumin derivatives were evaluated in vitro for the aldose reductase inhibitory activity.The results showed that curcuminoids and curcumin derivatives with hydroxyl or carboxyl acid groups exerted inhibitory activities on aldose reductase,and curcuminoid(N1) and curcumin derivative compound(N13) exhibited potential inhibitory activities.
