Two compositions,a pure ceramide and a sterol mixture,were isolated from the ethylacetate phase of ethanol extract of the Hypnea Charoides Lamx,collected from the South China Sea.The ceramide was identified by spectro...Two compositions,a pure ceramide and a sterol mixture,were isolated from the ethylacetate phase of ethanol extract of the Hypnea Charoides Lamx,collected from the South China Sea.The ceramide was identified by spectroscopic analysis as N-(2’hydroxytetracosyl)-1,3,4-trihydroxy-2-am ino-octadecane;The six sterols were detected by gas chromatography/mass spectrometry,and their structures were confirmed by spectroscopic analysis as Ergost-5,22-dien-3-ol,Ergost-5-en-3-ol,Stigmasta-5,22-dien-3-ol,Cholesta-5,22-dien-3-ol,Cholesta-5-en-3-ol,Stigmasta-5-en-3-ol.展开更多
Bioactivity-guided fractionation led to the isolation of a new steroidal saponin, orbiculatoside B, together with a pair of furostanol saponins, protobioside and methyl protobioside, from the fresh rhizomes of Dioscor...Bioactivity-guided fractionation led to the isolation of a new steroidal saponin, orbiculatoside B, together with a pair of furostanol saponins, protobioside and methyl protobioside, from the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculata. The new compound was identified to be isonarthogenin 3 O - a - L - rhamnopyranosyl (12) - [ a - L - rhamnopyranosyl - ( 1 4 ) ] - b - D - glucopyranoside by various NMR techniques in combination with chemical methods. The three saponins showed strong activity against Pyricularia oryzae, and were cytotoxic to cancer cell line K562, HCT-15, A549, and A2780a in vitro.展开更多
One of the analogues of icogenin, a natural furostanol saponin showing strong cytotoxic effect on cancer cell, was first synthesized via convergent strategy by using diosgenin and available monosaccharides as starting...One of the analogues of icogenin, a natural furostanol saponin showing strong cytotoxic effect on cancer cell, was first synthesized via convergent strategy by using diosgenin and available monosaccharides as starting materials.展开更多
文摘Two compositions,a pure ceramide and a sterol mixture,were isolated from the ethylacetate phase of ethanol extract of the Hypnea Charoides Lamx,collected from the South China Sea.The ceramide was identified by spectroscopic analysis as N-(2’hydroxytetracosyl)-1,3,4-trihydroxy-2-am ino-octadecane;The six sterols were detected by gas chromatography/mass spectrometry,and their structures were confirmed by spectroscopic analysis as Ergost-5,22-dien-3-ol,Ergost-5-en-3-ol,Stigmasta-5,22-dien-3-ol,Cholesta-5,22-dien-3-ol,Cholesta-5-en-3-ol,Stigmasta-5-en-3-ol.
文摘Bioactivity-guided fractionation led to the isolation of a new steroidal saponin, orbiculatoside B, together with a pair of furostanol saponins, protobioside and methyl protobioside, from the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculata. The new compound was identified to be isonarthogenin 3 O - a - L - rhamnopyranosyl (12) - [ a - L - rhamnopyranosyl - ( 1 4 ) ] - b - D - glucopyranoside by various NMR techniques in combination with chemical methods. The three saponins showed strong activity against Pyricularia oryzae, and were cytotoxic to cancer cell line K562, HCT-15, A549, and A2780a in vitro.
基金the National Natural Science Foundation of China （No 20372085） .
文摘One of the analogues of icogenin, a natural furostanol saponin showing strong cytotoxic effect on cancer cell, was first synthesized via convergent strategy by using diosgenin and available monosaccharides as starting materials.
