Ten novel 1, 1-dimethyl-3-(2-or 5-aryl-4-acetyl-2, 3-dihydro-1, 3, 4-oxadiazoline-5-or- 2-yl)-1, 2, 5, 6- tetrahydropyridinium iodides were synthesized from starting material nicotinalde- hyde or nicotinic acid by two...Ten novel 1, 1-dimethyl-3-(2-or 5-aryl-4-acetyl-2, 3-dihydro-1, 3, 4-oxadiazoline-5-or- 2-yl)-1, 2, 5, 6- tetrahydropyridinium iodides were synthesized from starting material nicotinalde- hyde or nicotinic acid by two different synthetic methods respectively. The preliminary bioactive tests indicate som compounds exhibit potent relaxing effect on endothelial cells, comparable to Ach or arecoline.展开更多
The structure of the piperidine derivative of elemene C20H33NCl3CCOOH was determined by Xray crystallography. The crystal belongs to the orthorhombic system, space group P212121, a=12.303(4), b=22.064(7), c=9.002(4),...The structure of the piperidine derivative of elemene C20H33NCl3CCOOH was determined by Xray crystallography. The crystal belongs to the orthorhombic system, space group P212121, a=12.303(4), b=22.064(7), c=9.002(4), V=2444(2)3, Z=4, Mr=450.88, Dc=1.23g/cm3, (MoK)=391cm-1, F(000)=960, Final R=0.050, Rw=0.067 for 2393 reflections I>3(I), GOF=1.91. The title compound is composed of trichloroacetate and the elemenyl piperidine cation. The latter contains two hexacyclic rings of elemene and piperidine, which adopt the chair conformations.\=展开更多
基金Financial support of this work by the State Key Basic Rescarch and Development Project(No.G 199805112)
文摘Ten novel 1, 1-dimethyl-3-(2-or 5-aryl-4-acetyl-2, 3-dihydro-1, 3, 4-oxadiazoline-5-or- 2-yl)-1, 2, 5, 6- tetrahydropyridinium iodides were synthesized from starting material nicotinalde- hyde or nicotinic acid by two different synthetic methods respectively. The preliminary bioactive tests indicate som compounds exhibit potent relaxing effect on endothelial cells, comparable to Ach or arecoline.
文摘The structure of the piperidine derivative of elemene C20H33NCl3CCOOH was determined by Xray crystallography. The crystal belongs to the orthorhombic system, space group P212121, a=12.303(4), b=22.064(7), c=9.002(4), V=2444(2)3, Z=4, Mr=450.88, Dc=1.23g/cm3, (MoK)=391cm-1, F(000)=960, Final R=0.050, Rw=0.067 for 2393 reflections I>3(I), GOF=1.91. The title compound is composed of trichloroacetate and the elemenyl piperidine cation. The latter contains two hexacyclic rings of elemene and piperidine, which adopt the chair conformations.\=
