Isothiocyanates(ITCs)are an important class of organic compounds characterized by the functional group R-N=C=S.These functional groups are widely found in multiple natural products and pharmaceutical important drugs.M...Isothiocyanates(ITCs)are an important class of organic compounds characterized by the functional group R-N=C=S.These functional groups are widely found in multiple natural products and pharmaceutical important drugs.Moreover,due to their high and versatile reactivity,they are widely used as an intermediate in organic synthesis.Keeping in view ITCs importance,this review summarizes their synthesis from nitrogen rich raw materials like amines,isocyanides,azides and some other compounds like oximes.Besides their synthesis,their application in organic compound synthesis as an intermediate will also be covered.Future research will likely focus on optimizing the synthesis of multifunctional isothiocyanates,understanding their complex biological mechanisms,exploring new applications,and highlighting the continued importance of isothiocyanates in modern chemistry and biotechnology.展开更多
Ionic liquids formed by imidazolium and pyridinium cations with Cl-,Br-,BF-4,and PF-6 anions were used for the catalytic synthesis of（2,3-）dichloropropionitrile by the chlorination of acrylonitrile.The ionic liquids...Ionic liquids formed by imidazolium and pyridinium cations with Cl-,Br-,BF-4,and PF-6 anions were used for the catalytic synthesis of（2,3-）dichloropropionitrile by the chlorination of acrylonitrile.The ionic liquids containing Cl-and Br-show good catalytic properties.The Cl-and Br-ions act as strong Lewis bases and molecular chlorine is activated by the induction effect of Cl-and Br-.Due to the stronger steric hindrance effect of the BF-4 and PF-6 anions,the chlorination of acrylonitrile is limited in the ionic liquids containing BF-4 and PF-6 anions.展开更多
文摘Isothiocyanates(ITCs)are an important class of organic compounds characterized by the functional group R-N=C=S.These functional groups are widely found in multiple natural products and pharmaceutical important drugs.Moreover,due to their high and versatile reactivity,they are widely used as an intermediate in organic synthesis.Keeping in view ITCs importance,this review summarizes their synthesis from nitrogen rich raw materials like amines,isocyanides,azides and some other compounds like oximes.Besides their synthesis,their application in organic compound synthesis as an intermediate will also be covered.Future research will likely focus on optimizing the synthesis of multifunctional isothiocyanates,understanding their complex biological mechanisms,exploring new applications,and highlighting the continued importance of isothiocyanates in modern chemistry and biotechnology.
文摘Ionic liquids formed by imidazolium and pyridinium cations with Cl-,Br-,BF-4,and PF-6 anions were used for the catalytic synthesis of（2,3-）dichloropropionitrile by the chlorination of acrylonitrile.The ionic liquids containing Cl-and Br-show good catalytic properties.The Cl-and Br-ions act as strong Lewis bases and molecular chlorine is activated by the induction effect of Cl-and Br-.Due to the stronger steric hindrance effect of the BF-4 and PF-6 anions,the chlorination of acrylonitrile is limited in the ionic liquids containing BF-4 and PF-6 anions.
