β-Amino nitroalkenes are important elements in the medicinal research and organic synthetic chemistry.Despite many documented methods,a facile and convenient synthesis remains desirable so far.Herein,a direct nitrati...β-Amino nitroalkenes are important elements in the medicinal research and organic synthetic chemistry.Despite many documented methods,a facile and convenient synthesis remains desirable so far.Herein,a direct nitration of tertiary enamide with tert-butyl nitrite(tBuONO)under metal-free conditions is disclosed.A wide array of cyclic and acyclic enamides was nitrated with commercially available nonmetallic reagents,which produced diverse valuableβ-acylamino nitroalkenes in excellent yields.Furthermore,this protocol is operationally simple and exhibits broad substrate scope and good functional group compatibility.展开更多
基金Project supported by the Shandong Provincial Natural Science Foundation(Nos.ZR2023MB135,ZR2024QB086)the Qingchuang Technology Support Program of University in Shandong Province(No.2023KJ244)。
文摘β-Amino nitroalkenes are important elements in the medicinal research and organic synthetic chemistry.Despite many documented methods,a facile and convenient synthesis remains desirable so far.Herein,a direct nitration of tertiary enamide with tert-butyl nitrite(tBuONO)under metal-free conditions is disclosed.A wide array of cyclic and acyclic enamides was nitrated with commercially available nonmetallic reagents,which produced diverse valuableβ-acylamino nitroalkenes in excellent yields.Furthermore,this protocol is operationally simple and exhibits broad substrate scope and good functional group compatibility.
基金the National Natural Science Foundation of China(21176033,21006007,21203193,21273029)Research Foundation for the Doctoral Program of Higher Education of China(20120042110024)~~
