Vaccination is a key strategy to curb the spread of epidemics.Heterologous vaccination,unlike homologous vaccination which acts on a single target and forms a single immune barrier,covers multiple targets for broader ...Vaccination is a key strategy to curb the spread of epidemics.Heterologous vaccination,unlike homologous vaccination which acts on a single target and forms a single immune barrier,covers multiple targets for broader protection.Yet,heterologous vaccination involves a complex decision process that conventional game-theoretic approaches,such as classical,evolutionary,and minority games cannot adequately capture.The parallel minority game(PMG)can handle bounded-rational,multi-choice decisions,but its application in vaccine research remains rare.In this study,we propose a vaccination-transmission coupled dynamic mechanism based on the parallel minority game and simulate it on a two-dimensional lattice.Using actual observational data and a mean-field mathematical model,we verify the effectiveness of this mechanism in simulating realistic vaccination behavior and transmission dynamics.We further analyze the impact of key parameters,such as vaccine efficacy differences and the proportion of individuals eligible for vaccine switching,on containment effectiveness.Our results demonstrate that heterologous vaccination surpasses homologous vaccination in containment effectiveness,particularly when vaccine efficacy varies significantly.This work provides a novel framework and empirical evidence for understanding individual decision-making and population-wide immunity formation in multi-vaccine settings.展开更多
The present study investigates the quest for a fully distributed Nash equilibrium(NE) in networked non-cooperative games, with particular emphasis on actuator limitations. Existing distributed NE seeking approaches of...The present study investigates the quest for a fully distributed Nash equilibrium(NE) in networked non-cooperative games, with particular emphasis on actuator limitations. Existing distributed NE seeking approaches often overlook practical input constraints or rely on centralized information. To address these issues, a novel edge-based double-layer adaptive control framework is proposed. Specifically, adaptive scaling parameters are embedded into the edge weights of the communication graph, enabling a fully distributed scheme that avoids dependence on centralized or global knowledge. Every participant modifies its strategy by exclusively utilizing local information and communicating with its neighbors to iteratively approach the NE. By incorporating damping terms into the design of the adaptive parameters, the proposed approach effectively suppresses unbounded parameter growth and consequently guarantees the boundedness of the adaptive gains. In addition, to account for actuator saturation, the proposed distributed NE seeking approach incorporates a saturation function, which ensures that control inputs do not exceed allowable ranges. A rigorous Lyapunov-based analysis guarantees the convergence and boundedness of all system variables. Finally, the presentation of simulation results aims to validate the efficacy and theoretical soundness of the proposed approach.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12571549,12571592,12471463,12022113,12101573)。
文摘Vaccination is a key strategy to curb the spread of epidemics.Heterologous vaccination,unlike homologous vaccination which acts on a single target and forms a single immune barrier,covers multiple targets for broader protection.Yet,heterologous vaccination involves a complex decision process that conventional game-theoretic approaches,such as classical,evolutionary,and minority games cannot adequately capture.The parallel minority game(PMG)can handle bounded-rational,multi-choice decisions,but its application in vaccine research remains rare.In this study,we propose a vaccination-transmission coupled dynamic mechanism based on the parallel minority game and simulate it on a two-dimensional lattice.Using actual observational data and a mean-field mathematical model,we verify the effectiveness of this mechanism in simulating realistic vaccination behavior and transmission dynamics.We further analyze the impact of key parameters,such as vaccine efficacy differences and the proportion of individuals eligible for vaccine switching,on containment effectiveness.Our results demonstrate that heterologous vaccination surpasses homologous vaccination in containment effectiveness,particularly when vaccine efficacy varies significantly.This work provides a novel framework and empirical evidence for understanding individual decision-making and population-wide immunity formation in multi-vaccine settings.
基金supported by the National Natural Science Foundation of China (Grant No.62173009)the National Key Research and Development Program of China (Grant No.2021ZD0112302)。
文摘The present study investigates the quest for a fully distributed Nash equilibrium(NE) in networked non-cooperative games, with particular emphasis on actuator limitations. Existing distributed NE seeking approaches often overlook practical input constraints or rely on centralized information. To address these issues, a novel edge-based double-layer adaptive control framework is proposed. Specifically, adaptive scaling parameters are embedded into the edge weights of the communication graph, enabling a fully distributed scheme that avoids dependence on centralized or global knowledge. Every participant modifies its strategy by exclusively utilizing local information and communicating with its neighbors to iteratively approach the NE. By incorporating damping terms into the design of the adaptive parameters, the proposed approach effectively suppresses unbounded parameter growth and consequently guarantees the boundedness of the adaptive gains. In addition, to account for actuator saturation, the proposed distributed NE seeking approach incorporates a saturation function, which ensures that control inputs do not exceed allowable ranges. A rigorous Lyapunov-based analysis guarantees the convergence and boundedness of all system variables. Finally, the presentation of simulation results aims to validate the efficacy and theoretical soundness of the proposed approach.
