Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.Thi...Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria,incorporating both human and mosquito populations.We aim to identify the key factors driving the endemic spread of malaria,determine feasible solutions,and provide insights that lead to the development of effective prevention and management strategies.We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and endemic equilibrium points.Stability analyses indicate that the disease-free equilibrium is locally and globally stable when the reproductive number is below one,whereas an endemic equilibrium persists when this threshold is exceeded.Sensitivity analysis identifies the most influential mosquito-related parameters,particularly the bite rate and mosquito mortality,in controlling the spread of malaria.Furthermore,we extend our model to include a treatment compartment and three disease-preventive control variables such as antimalaria drug treatments,use of larvicides,and the use of insecticide-treated mosquito nets for optimal control analysis.The results show that optimal use of mosquito nets,use of larvicides for mosquito population control,and treatment can lower the basic reproduction number and control malaria transmission with minimal intervention costs.The analysis of disease control strategies and findings offers valuable information for policymakers in designing cost-effective strategies to combat malaria.展开更多
针对透平叶片坯料种类繁多、形状复杂和模型不易修改等问题,利用UG 12.0二次开发工具以及Visual Studio 2015编程软件设计了一种基于模板的叶片坯料参数化建模系统。在研究现有参数化设计的基础上,通过表格存储不同类型叶片坯料的尺寸数...针对透平叶片坯料种类繁多、形状复杂和模型不易修改等问题,利用UG 12.0二次开发工具以及Visual Studio 2015编程软件设计了一种基于模板的叶片坯料参数化建模系统。在研究现有参数化设计的基础上,通过表格存储不同类型叶片坯料的尺寸数据,建立了透平叶片坯料模型的重用库。实例证明,该系统可以根据工程实际需求,通过修改叶片坯料的模型参数,方便快捷地得到设计人员所需要的叶片坯料模型和二维工程图,缩短了透平叶片锻坯的设计开发周期。重用库的设计提高了企业内工程师调用和查验所需叶片坯料的效率,减少了出错概率。展开更多
基金supported by the Deanship of Scientific Research,Vice Presidency for Graduate Studies and Scientific Research,King Faisal University,Saudi Arabia[Grant No.KFU252959].
文摘Malaria is a significant global health challenge.This devastating disease continues to affect millions,especially in tropical regions.It is caused by Plasmodium parasites transmitted by female Anopheles mosquitoes.This study introduces a nonlinear mathematical model for examining the transmission dynamics of malaria,incorporating both human and mosquito populations.We aim to identify the key factors driving the endemic spread of malaria,determine feasible solutions,and provide insights that lead to the development of effective prevention and management strategies.We derive the basic reproductive number employing the next-generation matrix approach and identify the disease-free and endemic equilibrium points.Stability analyses indicate that the disease-free equilibrium is locally and globally stable when the reproductive number is below one,whereas an endemic equilibrium persists when this threshold is exceeded.Sensitivity analysis identifies the most influential mosquito-related parameters,particularly the bite rate and mosquito mortality,in controlling the spread of malaria.Furthermore,we extend our model to include a treatment compartment and three disease-preventive control variables such as antimalaria drug treatments,use of larvicides,and the use of insecticide-treated mosquito nets for optimal control analysis.The results show that optimal use of mosquito nets,use of larvicides for mosquito population control,and treatment can lower the basic reproduction number and control malaria transmission with minimal intervention costs.The analysis of disease control strategies and findings offers valuable information for policymakers in designing cost-effective strategies to combat malaria.
文摘针对透平叶片坯料种类繁多、形状复杂和模型不易修改等问题,利用UG 12.0二次开发工具以及Visual Studio 2015编程软件设计了一种基于模板的叶片坯料参数化建模系统。在研究现有参数化设计的基础上,通过表格存储不同类型叶片坯料的尺寸数据,建立了透平叶片坯料模型的重用库。实例证明,该系统可以根据工程实际需求,通过修改叶片坯料的模型参数,方便快捷地得到设计人员所需要的叶片坯料模型和二维工程图,缩短了透平叶片锻坯的设计开发周期。重用库的设计提高了企业内工程师调用和查验所需叶片坯料的效率,减少了出错概率。
