背景:全身振动训练已广泛应用于运动表现、康复医学及健康管理等多个领域。目的:通过CiteSpace软件对全身振动训练方法的国内外应用研究进行可视化分析,揭示该领域的研究进展、热点问题及未来发展趋势。方法:在中国知网和Web of Scienc...背景:全身振动训练已广泛应用于运动表现、康复医学及健康管理等多个领域。目的:通过CiteSpace软件对全身振动训练方法的国内外应用研究进行可视化分析,揭示该领域的研究进展、热点问题及未来发展趋势。方法:在中国知网和Web of Science数据库中选取2000-2024年期间全身振动领域的文献,利用CiteSpace V(6.2.R6)软件对文献的发表趋势、合作网络、关键词聚类及研究热点进行可视化分析。结果与结论:共纳入661篇中文文献和1005篇英文文献,国内外全身振动领域研究呈现逐年增长的趋势。国内研究主要集中于振动训练对运动表现和康复应用的影响,特别是在老年人、运动员和特定疾病患者中的应用;国外研究更加注重全身振动对神经肌肉功能、代谢综合征及慢性疾病患者的康复效果。国内全身振动相关研究的热点集中在振动频率、振动训练和振动治疗方面,国外全身振动相关研究侧重姿势控制、肌肉力量及全身振动的综合效果。未来全身振动训练的研究应加强跨国合作、优化训练参数,探索在不同人群中的个性化应用,推动全身振动技术在体育、康复及健康管理中广泛应用。展开更多
On a summer morning in Boqiang Village,tucked beneath the emerald mountains of Fanshi County,Shanxi Province,the Ultra Trail Mount Wutai2025 commenced with the sound of the starting pistol-an event that was much more ...On a summer morning in Boqiang Village,tucked beneath the emerald mountains of Fanshi County,Shanxi Province,the Ultra Trail Mount Wutai2025 commenced with the sound of the starting pistol-an event that was much more than just a competition.As soon as the colorful smoke bombs lit up the sky,some2,000 runners from China and abroad set off to reach one of the country's most sacred Buddhist peaks.Over the past decade,this race has become a fixture on the global running calendar and a symbol of the growing popularity of endurance sports.展开更多
Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-in...Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.展开更多
文摘背景:全身振动训练已广泛应用于运动表现、康复医学及健康管理等多个领域。目的:通过CiteSpace软件对全身振动训练方法的国内外应用研究进行可视化分析,揭示该领域的研究进展、热点问题及未来发展趋势。方法:在中国知网和Web of Science数据库中选取2000-2024年期间全身振动领域的文献,利用CiteSpace V(6.2.R6)软件对文献的发表趋势、合作网络、关键词聚类及研究热点进行可视化分析。结果与结论:共纳入661篇中文文献和1005篇英文文献,国内外全身振动领域研究呈现逐年增长的趋势。国内研究主要集中于振动训练对运动表现和康复应用的影响,特别是在老年人、运动员和特定疾病患者中的应用;国外研究更加注重全身振动对神经肌肉功能、代谢综合征及慢性疾病患者的康复效果。国内全身振动相关研究的热点集中在振动频率、振动训练和振动治疗方面,国外全身振动相关研究侧重姿势控制、肌肉力量及全身振动的综合效果。未来全身振动训练的研究应加强跨国合作、优化训练参数,探索在不同人群中的个性化应用,推动全身振动技术在体育、康复及健康管理中广泛应用。
文摘On a summer morning in Boqiang Village,tucked beneath the emerald mountains of Fanshi County,Shanxi Province,the Ultra Trail Mount Wutai2025 commenced with the sound of the starting pistol-an event that was much more than just a competition.As soon as the colorful smoke bombs lit up the sky,some2,000 runners from China and abroad set off to reach one of the country's most sacred Buddhist peaks.Over the past decade,this race has become a fixture on the global running calendar and a symbol of the growing popularity of endurance sports.
基金supported by grants from the Knut and Alice Wallenberg foundation(P-OB,JRZ,and AK)the Swedish Research Council(JRZ and AK),Centrum för idrottsforskning(AK and JRZ)+7 种基金the NovoNordisk Foundation Metabolic Stress Associated Molecules(MSAM)consortium NNF15SA0018346 and Metabolite-related Inflammation and Disease(MeRIAD)consortium Grant number 0064142(AK)the Swedish Diabetes Foundation(AK and JRZ)the European Foundation for the Study of Diabetes(JRZ and AK)the Region Stockholm(ALF project)(JRZ and KC)the Strategic Research Program in Diabetes at Karolinska Institutet(JRZ and AK)supported by the Strategic Research Programme in Diabetes(SRP Diabetes)for use of the Seahorse flux analyzer.Human islets were made possible through the Juvenile Diabetes Research Foundation(JDRF)award 31-2008-416(European Coordinating Infrastructure for Islet Transplantation(ECIT),Islet for Basic Research program)AK holds a Distinguished Investigator Grant within Endocrinology and Metabolism from the Novo Nordisk Foundation(NNF24OC0088739)JRZ received the 2024 European Association for the Study of Diabetes(ESAD)-Novo Nordisk Foundation Diabetes Prize for Excellence(NNF24SA0092609).
文摘Background Regular physical training induces adaptive effects across multiple organ systems,highlighting the existence of inter-organ communication networks.However,the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized.Circulating extracellular vesicles(EVs),including exosomes,carry molecules like microRNAs(miRNAs)that may mediate tissue crosstalk.This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.Methods miRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training.Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.Results We identified several exercise training-responsive miRNAs within exosome-rich EVs in serum,including miR-136-3p.In human myotubes,miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase(NRDC)gene.Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis.Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.Conclusion MiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes.Associated with EVs,extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk after exercise.Extracellular miR-136-3p may serve as a molecular messenger to communicate islet–skeletal muscle crosstalk.Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.
