Background and objective Once the malignant pleural or peritoneal effusion is developed it is difficult to control.This report presents a new method for controlling the malignant effusions.Methods Forty-eight patients...Background and objective Once the malignant pleural or peritoneal effusion is developed it is difficult to control.This report presents a new method for controlling the malignant effusions.Methods Forty-eight patients,29 males and 19 females with an average age of 61.2 years old,who were satisfied with the study inclusion criteria,were recruited in this study.Twenty-seven and 21 patients had a malignant pleural and peritoneal effusion,respectively.After draining most of fluids,these patients received intra-cavity infusion of rAd-p53 once per week for 4 weeks,at dose of 2×1012 viral particles(VP) diluted into 200 mL of saline solution for pleural effusions,and 4×1012 VP diluted into 500 mL of saline solution for peritoneal effusions.Results Participants were followed up for a median time of 13.6 month.A total of 11 cases,7 with pleural effusions and 4 with peritoneal effusions achieved a complete response(CR),and 20 cases(12 pleural effusions and 8 peritoneal effusions) had a partial response(PR).The overall response rate is 64.6%.Patients' quality of life,assessed by using Karnofsky performance scale(KPS) scores,was improved by an average of 26.4.The one-year of overall survival rate was 54.2% with a median survival time of 12.5 months.There were no serious side effects observed except for self-limited fever found in 79.8% of the cases.Conclusions Intra-cavity infusion of rAd-p53 is an effective and safe treatment for the patients with malignant pleural or peritoneal effusions,especially for those patients who can't tolerate the standard treatments.展开更多
目的运用网络针灸学探究针灸治疗周围性面瘫急性期核心穴位及可能的作用机制。方法检索中国知网、万方数据库、维普期刊数据库及Web of Science,选取建库至2024年6月1日的相关文献,提取针灸治疗周围性面瘫急性期腧穴处方,进行频次分析...目的运用网络针灸学探究针灸治疗周围性面瘫急性期核心穴位及可能的作用机制。方法检索中国知网、万方数据库、维普期刊数据库及Web of Science,选取建库至2024年6月1日的相关文献,提取针灸治疗周围性面瘫急性期腧穴处方,进行频次分析及高频穴位筛选,进一步通过关联规则分析确定核心穴方,并对核心穴方进行潜在靶点挖掘,构建蛋白质相互作用(PPI)网络,提取核心靶点,并利用基因本体(GO)富集和KEGG富集分析预测其作用机制。结果共纳入文献处方134条,筛选出核心穴位合谷、太冲、地仓、阳白、颊车。挖掘潜在靶点243个,与周围性面瘫共有靶点94个,筛选出蛋白激酶B1(AKT1)、脑源性神经营养因子(BDNF)、信号转导与转录激活因子3(STAT3)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、B细胞淋巴瘤-2蛋白(BCL2)、神经生长因子(NGF)、转录因子AP-1亚基(JUN)、血管内皮生长因子(VEGF)、cAMP应答元件结合蛋白1(CREB1)核心靶点;富集分析结果显示,核心靶点主要涉及神经营养因子信号通路、AGE-RAGE、Relaxin信号通路等;涉及神经元凋亡、神经营养与修复、炎性反应等生物学过程。结论针灸治疗周围性面瘫急性期核心穴方通过多靶点、多通路协同发挥治疗作用。展开更多
BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve outcomes.Large language models(LLMs)can potentially provide medical information for patients.AIM To examine the...BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve outcomes.Large language models(LLMs)can potentially provide medical information for patients.AIM To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related questions.METHODS LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third reviewer.Each question was run three times using three LLMs.Readability was assessed via the Gunning Fog index and Flesch-Kincaid grade level.RESULTS Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google Gemini.Across the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical manifestations.Notably,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal population.CONCLUSION Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related questions.LLMs may be an adjunctive informational tool for patients and physicians to improve outcomes.Nevertheless,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.展开更多
The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are...The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are required in the process of plant supplementing light,arrow-band emitting phosphors are applied to backlight displays,etc.In this work,a Bi^(3+)-activated blue phosphor was obtained in a symmetrical and co mpact crystal structure of Gd3Sb07(GSO).Then,the co-doping strategy of alkali metal ions(Li^(+),Na^(+),and K^(+))was used to optimize the performance.The result shows that the photoluminescence intensity is increased by 2.1 times and 1.3 times respectively by introducing Li~+and K^(+)ions.Not only that,it also achieves narrow-band emitting with the full width of half-maximum(FWHM)reaching 42 nm through Na^(+)doping,and its excitation peak position also shifts from 322 to 375 nm,which can be well excited by near-ultraviolet(NUV)light emitting diode(LED)chips(365 nm).Meanwhile,the electroluminescence spectrum of GSO:0.6 mol%Bi^(3+),3 wt%Na^(+)matches up to 93.39%of the blue part of the absorption spectrum of chlorophyll a.In summary,the Bi^(3+)-activated blue phosphor reported in this work can synchronously meet the requirements of plant light replenishment and field emission displays.展开更多
Herein,an external crosslinker facilitated the hypercrosslinking of ferrocene and a nitrogen heterocyclic compound(either melamine or imidazole)through a direct Friedel-Crafts reaction,which led to the formation of ni...Herein,an external crosslinker facilitated the hypercrosslinking of ferrocene and a nitrogen heterocyclic compound(either melamine or imidazole)through a direct Friedel-Crafts reaction,which led to the formation of nitrogen-containing hypercrosslinked fer-rocene polymer precursors(HCP-FCs).Subsequent carbonization of these precursors results in the production of iron-nitrogen-doped por-ous carbon absorbers(Fe-NPCs).The Fe-NPCs demonstrate a porous structure comprising aggregated nanotubes and nanospheres.The porosity of this structure can be modulated by adjusting the iron and nitrogen contents to optimize impedance matching.The uniform dis-tribution of Fe-N_(x)C,N dipoles,andα-Fe within the carbon matrix can be ensured by using hypercrosslinked ferrocenes in constructing porous carbon,providing the absorber with numerous polarization sites and a conductive network.The electromagnetic wave absorption performance of the specially designed Fe-NPC-M_(2)absorbers is satisfactory,revealing a minimum reflection loss of-55.3 dB at 2.5 mm and an effective absorption bandwidth of 6.00 GHz at 2.0 mm.By utilizing hypercrosslinked polymers(HCPs)as precursors,a novel method for developing highly efficient carbon-based absorbing agents is introduced in this research.展开更多
背景与目的肺腺癌(lung adenocarcinoma,LUAD)是非小细胞肺癌(non-small cell lung cancer,NSCLC)的主要亚型。损伤特异性DNA结合蛋白1(damage-specific DNA binding protein 1,DDB1)作为CUL4-DDB1泛素连接酶复合体的核心蛋白,参与调控...背景与目的肺腺癌(lung adenocarcinoma,LUAD)是非小细胞肺癌(non-small cell lung cancer,NSCLC)的主要亚型。损伤特异性DNA结合蛋白1(damage-specific DNA binding protein 1,DDB1)作为CUL4-DDB1泛素连接酶复合体的核心蛋白,参与调控DNA损伤修复、表观遗传修饰及细胞周期检查点激活等关键生物学过程。有报道DDB1通过DNA修复与RNA转录调控参与肿瘤进展,但其在LUAD中的表达及作用尚不明确。本研究旨在探讨DDB1在LUAD中的表达和作用。方法利用UALCAN、Kaplan-Meier Plotter、GEPIA等数据库,对DDB1在LUAD中的表达及预后、临床病理特征等进行分析;通过GeneMANIA和Metascape构建相互作用网络及富集功能通路;结合TISIDB评估DDB1与免疫细胞浸润相关性,通过单细胞测序对细胞亚型的聚类结果和DDB1在不同免疫细胞亚群中的表达情况进行分析;最后,利用组织芯片进一步验证DDB1在LUAD中的表达及预后价值。结果DDB1在LUAD组织中的表达显著高于正常组织(P<0.01),且高表达与肿瘤原发灶-淋巴结-转移(tumor-node-metastasis,TNM)分期较晚(P<0.001)、淋巴结转移(P<0.001)及预后不良(P<0.001)有关。功能富集显示DDB1参与DNA修复与RNA转录调控。TISIDB评估发现DDB1与免疫细胞的表达水平呈负相关,提示存在免疫微环境调控潜力。单细胞分析显示,DDB1主要在T细胞、肺泡巨噬细胞以及树突状细胞中表达。组织芯片证实DDB1高表达组总生存期更短(P<0.001),Cox多因素分析表明DDB1为预测LUAD预后的独立因子。结论DDB1在LUAD中高表达,与患者预后不良有关,并且与肿瘤免疫细胞浸润密切相关,通过DNA修复与RNA转录调控参与肿瘤发生发展。DDB1可作为LUAD潜在的预后标志物及治疗靶点。展开更多
Certain transients require regular observations over several days at intervals of hours or shorter,which cannot be accomplished by telescopes at a single site.The deployment of globally distributed telescopes at geogr...Certain transients require regular observations over several days at intervals of hours or shorter,which cannot be accomplished by telescopes at a single site.The deployment of globally distributed telescopes at geographic locations of different longitudes enables the periodic monitoring of transients through relay observation.However,the simultaneous relay observation of numerous targets requires a telescope array of multiple telescopes that can be efficiently coordinated,and an automated scheduler for the array.This paper proposes IPROS,an integer programming model relay observation scheduler for a telescope array,that accounts for the entire process of relay observation and is consistent with the practical scenarios.We introduce the integer programming mathematical model for the relay observation scheduling problem with the telescope array,upon which the scheduler is based.Additionally,we propose an algorithm to provide a comprehensive formulation of the optimization objective of minimizing cadence deviation in the model.Experimental results demonstrate that the relay observation scheduler based on the integer programming model can effectively address the telescope array relay observation problem.It shows superiority over a scheduler with non-specific consideration of relay observation in the modeling and a scheduler based on greedy thought.展开更多
The Mini-SiTian project,which is a pathfinder for the SiTian project,utilizes three 30 cm telescopes equipped with commercial CMOS cameras(ZWO ASI6200MM Pro)to simulate a large-area time-domain survey.Due to the avoid...The Mini-SiTian project,which is a pathfinder for the SiTian project,utilizes three 30 cm telescopes equipped with commercial CMOS cameras(ZWO ASI6200MM Pro)to simulate a large-area time-domain survey.Due to the avoidance of the traditional mechanical shutter,the CMOS camera is favorable in time-domain survey projects.In the future,the SiTian telescope array will employ a two-by-two scientific-grade mosaic CMOS camera to survey a10,000 degree square area every 30 minutes.Therefore,the performance of CMOS directly determines the detection capability of SiTian telescopes for transient sources,and a comprehensive understanding of the performance of CMOS cameras is crucial.In this research,laboratory testing was conducted to thoroughly evaluate three cameras by assessing several critical parameters,including bias stability,dark current,pixel anomalies,linearity,gain,and read noise.We find exceptional short-term bias stability with standard deviations below 0.02 ADU,negligible dark current of approximately 0.002 e-pixel^(-1)s^(-1)at 0℃,and excellent linearity with nonlinearity consistently below±0.5%,and a small proportion(0.06%-0.08%)of pixels with anomalous responses.Furthermore,our analysis demonstrates uniform gain values across all cameras,ranging from 0.252 to 0.255 e-ADU^(-1),with low readout noise,measured to be below 1.6 e-using conventional methods.We also propose a novel method for pixel-level gain and read noise calculation for CMOS sensors,which revealed a narrow gain distribution and a low median read noise of 1.028 e-for one of the cameras.The laboratory testing of the ZWO ASI6200MM Pro cameras indicates their potential to meet the requirements of time-domain surveys for the Mini-SiTian project.展开更多
Chase-and-escape motion,which is a typical behavior between a predator and prey,is an important dynamics in animate systems.It has been concerned recently in optics aiming for achieving novel light steering and switch...Chase-and-escape motion,which is a typical behavior between a predator and prey,is an important dynamics in animate systems.It has been concerned recently in optics aiming for achieving novel light steering and switching functions.However,this optical counterpart can be realized in only one dimension because of the challenges in maintaining the chase-and-escape interaction.Herein,we report,both theoretically and experimentally,the optical predator-prey dynamics in two dimensions for the first time.Upon nonreciprocal interaction,two beams can form a localized or oblique spiral chase-and-escape motion,which persists owing to the mutual light confinement.Unusual optical phenomena are observed in these dynamics:the angular momentum is not conserved and the resulting transverse traveling motion can be opposite to the applied initial momentum and enhanced by increasing the internal light interactions.The results can inspire further fundamental studies by exploring analogous animate phenomena in optics that are potentially useful for developing optical intelligence functions.展开更多
The SiTian Project represents a groundbreaking initiative in astronomy,aiming to deploy a global network of telescopes,each with a 1 m aperture,for comprehensive time-domain sky surveys.The network's innovative ar...The SiTian Project represents a groundbreaking initiative in astronomy,aiming to deploy a global network of telescopes,each with a 1 m aperture,for comprehensive time-domain sky surveys.The network's innovative architecture features multiple observational nodes,each comprising three strategically aligned telescopes equipped with filters.This design enables three-color(g,r,i)channel imaging within each node,facilitating precise and coordinated observations.As a pathfinder to the full-scale project,the Mini-SiTian Project serves as the scientific and technological validation platform,utilizing three 30 cm aperture telescopes to validate the methodologies and technologies planned for the broader SiTian network.This paper focuses on the development and implementation of the Master Control System(MCS),and the central command hub for the Mini-SiTian Array.The MCS is designed to facilitate seamless communication with the SiTian Brain,the project's central processing and decisionmaking unit,while ensuring accurate task allocation,real-time status monitoring,and optimized observational workflows.The system adopts a robust architecture that separates front-end and back-end functionalities.A key innovation of the MCS is its ability to dynamically adjust observation plans in response to transient source alerts,enabling rapid and coordinated scans of target sky regions.The paper provides an in-depth analysis of the system's internal components,including the communication system,which is critical for seamless network operation.Extensive testing has validated the functionality,reliability,and compatibility of these components within the overall system architecture.The successful deployment of the MCS in managing the Mini-SiTian Array has demonstrated its practicality and efficacy in collaborative observation and distributed control.By simplifying cluster management and ensuring data integrity,the MCS represents a significant advancement in astronomical observation control systems.Its scalable and adaptable design not only supports the future expansion of the SiTian network but also provides a blueprint for other large-scale telescope arrays,marking a transformative step forward in time-domain astronomy.展开更多
文摘Background and objective Once the malignant pleural or peritoneal effusion is developed it is difficult to control.This report presents a new method for controlling the malignant effusions.Methods Forty-eight patients,29 males and 19 females with an average age of 61.2 years old,who were satisfied with the study inclusion criteria,were recruited in this study.Twenty-seven and 21 patients had a malignant pleural and peritoneal effusion,respectively.After draining most of fluids,these patients received intra-cavity infusion of rAd-p53 once per week for 4 weeks,at dose of 2×1012 viral particles(VP) diluted into 200 mL of saline solution for pleural effusions,and 4×1012 VP diluted into 500 mL of saline solution for peritoneal effusions.Results Participants were followed up for a median time of 13.6 month.A total of 11 cases,7 with pleural effusions and 4 with peritoneal effusions achieved a complete response(CR),and 20 cases(12 pleural effusions and 8 peritoneal effusions) had a partial response(PR).The overall response rate is 64.6%.Patients' quality of life,assessed by using Karnofsky performance scale(KPS) scores,was improved by an average of 26.4.The one-year of overall survival rate was 54.2% with a median survival time of 12.5 months.There were no serious side effects observed except for self-limited fever found in 79.8% of the cases.Conclusions Intra-cavity infusion of rAd-p53 is an effective and safe treatment for the patients with malignant pleural or peritoneal effusions,especially for those patients who can't tolerate the standard treatments.
文摘目的运用网络针灸学探究针灸治疗周围性面瘫急性期核心穴位及可能的作用机制。方法检索中国知网、万方数据库、维普期刊数据库及Web of Science,选取建库至2024年6月1日的相关文献,提取针灸治疗周围性面瘫急性期腧穴处方,进行频次分析及高频穴位筛选,进一步通过关联规则分析确定核心穴方,并对核心穴方进行潜在靶点挖掘,构建蛋白质相互作用(PPI)网络,提取核心靶点,并利用基因本体(GO)富集和KEGG富集分析预测其作用机制。结果共纳入文献处方134条,筛选出核心穴位合谷、太冲、地仓、阳白、颊车。挖掘潜在靶点243个,与周围性面瘫共有靶点94个,筛选出蛋白激酶B1(AKT1)、脑源性神经营养因子(BDNF)、信号转导与转录激活因子3(STAT3)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、B细胞淋巴瘤-2蛋白(BCL2)、神经生长因子(NGF)、转录因子AP-1亚基(JUN)、血管内皮生长因子(VEGF)、cAMP应答元件结合蛋白1(CREB1)核心靶点;富集分析结果显示,核心靶点主要涉及神经营养因子信号通路、AGE-RAGE、Relaxin信号通路等;涉及神经元凋亡、神经营养与修复、炎性反应等生物学过程。结论针灸治疗周围性面瘫急性期核心穴方通过多靶点、多通路协同发挥治疗作用。
基金Supported by National Natural Science Foundation of China,No.82260133the Key Laboratory Project of Digestive Diseases in Jiangxi Province,No.2024SSY06101Jiangxi Clinical Research Center for Gastroenterology,No.20223BCG74011.
文摘BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve outcomes.Large language models(LLMs)can potentially provide medical information for patients.AIM To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related questions.METHODS LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third reviewer.Each question was run three times using three LLMs.Readability was assessed via the Gunning Fog index and Flesch-Kincaid grade level.RESULTS Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google Gemini.Across the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical manifestations.Notably,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal population.CONCLUSION Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related questions.LLMs may be an adjunctive informational tool for patients and physicians to improve outcomes.Nevertheless,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.
基金Project supported by the Key R&D Projects in Hunan Province(2021SK2047,2022NK2044)Science and Technology Innovation Program of Hunan Province(2022WZ1022)Superior Youth Project of the Science Research Project of Hunan Provincial Department of Education(22B0211)。
文摘The technology of solid-state lighting has developed for decades in various industries.Phosphor,as an element part,determines the application domain of lighting products.For instance,blue and redemitting phosphors are required in the process of plant supplementing light,arrow-band emitting phosphors are applied to backlight displays,etc.In this work,a Bi^(3+)-activated blue phosphor was obtained in a symmetrical and co mpact crystal structure of Gd3Sb07(GSO).Then,the co-doping strategy of alkali metal ions(Li^(+),Na^(+),and K^(+))was used to optimize the performance.The result shows that the photoluminescence intensity is increased by 2.1 times and 1.3 times respectively by introducing Li~+and K^(+)ions.Not only that,it also achieves narrow-band emitting with the full width of half-maximum(FWHM)reaching 42 nm through Na^(+)doping,and its excitation peak position also shifts from 322 to 375 nm,which can be well excited by near-ultraviolet(NUV)light emitting diode(LED)chips(365 nm).Meanwhile,the electroluminescence spectrum of GSO:0.6 mol%Bi^(3+),3 wt%Na^(+)matches up to 93.39%of the blue part of the absorption spectrum of chlorophyll a.In summary,the Bi^(3+)-activated blue phosphor reported in this work can synchronously meet the requirements of plant light replenishment and field emission displays.
基金supported by the National Natural Science Foundation of China(No.51803041)the University and Local Integration Development Project of Yantai,China(No.2022 XDRHXMXK08).
文摘Herein,an external crosslinker facilitated the hypercrosslinking of ferrocene and a nitrogen heterocyclic compound(either melamine or imidazole)through a direct Friedel-Crafts reaction,which led to the formation of nitrogen-containing hypercrosslinked fer-rocene polymer precursors(HCP-FCs).Subsequent carbonization of these precursors results in the production of iron-nitrogen-doped por-ous carbon absorbers(Fe-NPCs).The Fe-NPCs demonstrate a porous structure comprising aggregated nanotubes and nanospheres.The porosity of this structure can be modulated by adjusting the iron and nitrogen contents to optimize impedance matching.The uniform dis-tribution of Fe-N_(x)C,N dipoles,andα-Fe within the carbon matrix can be ensured by using hypercrosslinked ferrocenes in constructing porous carbon,providing the absorber with numerous polarization sites and a conductive network.The electromagnetic wave absorption performance of the specially designed Fe-NPC-M_(2)absorbers is satisfactory,revealing a minimum reflection loss of-55.3 dB at 2.5 mm and an effective absorption bandwidth of 6.00 GHz at 2.0 mm.By utilizing hypercrosslinked polymers(HCPs)as precursors,a novel method for developing highly efficient carbon-based absorbing agents is introduced in this research.
文摘背景与目的肺腺癌(lung adenocarcinoma,LUAD)是非小细胞肺癌(non-small cell lung cancer,NSCLC)的主要亚型。损伤特异性DNA结合蛋白1(damage-specific DNA binding protein 1,DDB1)作为CUL4-DDB1泛素连接酶复合体的核心蛋白,参与调控DNA损伤修复、表观遗传修饰及细胞周期检查点激活等关键生物学过程。有报道DDB1通过DNA修复与RNA转录调控参与肿瘤进展,但其在LUAD中的表达及作用尚不明确。本研究旨在探讨DDB1在LUAD中的表达和作用。方法利用UALCAN、Kaplan-Meier Plotter、GEPIA等数据库,对DDB1在LUAD中的表达及预后、临床病理特征等进行分析;通过GeneMANIA和Metascape构建相互作用网络及富集功能通路;结合TISIDB评估DDB1与免疫细胞浸润相关性,通过单细胞测序对细胞亚型的聚类结果和DDB1在不同免疫细胞亚群中的表达情况进行分析;最后,利用组织芯片进一步验证DDB1在LUAD中的表达及预后价值。结果DDB1在LUAD组织中的表达显著高于正常组织(P<0.01),且高表达与肿瘤原发灶-淋巴结-转移(tumor-node-metastasis,TNM)分期较晚(P<0.001)、淋巴结转移(P<0.001)及预后不良(P<0.001)有关。功能富集显示DDB1参与DNA修复与RNA转录调控。TISIDB评估发现DDB1与免疫细胞的表达水平呈负相关,提示存在免疫微环境调控潜力。单细胞分析显示,DDB1主要在T细胞、肺泡巨噬细胞以及树突状细胞中表达。组织芯片证实DDB1高表达组总生存期更短(P<0.001),Cox多因素分析表明DDB1为预测LUAD预后的独立因子。结论DDB1在LUAD中高表达,与患者预后不良有关,并且与肿瘤免疫细胞浸润密切相关,通过DNA修复与RNA转录调控参与肿瘤发生发展。DDB1可作为LUAD潜在的预后标志物及治疗靶点。
基金supported by the National Key Research and Development Program of China No.2023YFA1608301the National Natural Science Foundation of China(NSFC,grant Nos.12133010 and 12273025)
文摘Certain transients require regular observations over several days at intervals of hours or shorter,which cannot be accomplished by telescopes at a single site.The deployment of globally distributed telescopes at geographic locations of different longitudes enables the periodic monitoring of transients through relay observation.However,the simultaneous relay observation of numerous targets requires a telescope array of multiple telescopes that can be efficiently coordinated,and an automated scheduler for the array.This paper proposes IPROS,an integer programming model relay observation scheduler for a telescope array,that accounts for the entire process of relay observation and is consistent with the practical scenarios.We introduce the integer programming mathematical model for the relay observation scheduling problem with the telescope array,upon which the scheduler is based.Additionally,we propose an algorithm to provide a comprehensive formulation of the optimization objective of minimizing cadence deviation in the model.Experimental results demonstrate that the relay observation scheduler based on the integer programming model can effectively address the telescope array relay observation problem.It shows superiority over a scheduler with non-specific consideration of relay observation in the modeling and a scheduler based on greedy thought.
基金supported by the National Key R&D Program of China(grant Nos.2023YFA1609700,2023YFA1608304,and2023YFA1608303)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0550103)+1 种基金the National Natural Science Foundation of China(NSFC,Nos.12090040 and 12090041)supported from the Strategic Pioneer Program of the Astronomy Large-Scale Scientific Facility,Chinese Academy of Sciences,and the Science and Education Integration Funding of the University of Chinese Academy of Sciences。
文摘The Mini-SiTian project,which is a pathfinder for the SiTian project,utilizes three 30 cm telescopes equipped with commercial CMOS cameras(ZWO ASI6200MM Pro)to simulate a large-area time-domain survey.Due to the avoidance of the traditional mechanical shutter,the CMOS camera is favorable in time-domain survey projects.In the future,the SiTian telescope array will employ a two-by-two scientific-grade mosaic CMOS camera to survey a10,000 degree square area every 30 minutes.Therefore,the performance of CMOS directly determines the detection capability of SiTian telescopes for transient sources,and a comprehensive understanding of the performance of CMOS cameras is crucial.In this research,laboratory testing was conducted to thoroughly evaluate three cameras by assessing several critical parameters,including bias stability,dark current,pixel anomalies,linearity,gain,and read noise.We find exceptional short-term bias stability with standard deviations below 0.02 ADU,negligible dark current of approximately 0.002 e-pixel^(-1)s^(-1)at 0℃,and excellent linearity with nonlinearity consistently below±0.5%,and a small proportion(0.06%-0.08%)of pixels with anomalous responses.Furthermore,our analysis demonstrates uniform gain values across all cameras,ranging from 0.252 to 0.255 e-ADU^(-1),with low readout noise,measured to be below 1.6 e-using conventional methods.We also propose a novel method for pixel-level gain and read noise calculation for CMOS sensors,which revealed a narrow gain distribution and a low median read noise of 1.028 e-for one of the cameras.The laboratory testing of the ZWO ASI6200MM Pro cameras indicates their potential to meet the requirements of time-domain surveys for the Mini-SiTian project.
基金supported by the National Key R&D Program of China(Grant No.2022YFA1404800)the National Natural Science Foundation of China(Grant Nos.12250009 and 62075105)the 111 Project in China(Grant No.B23045)。
文摘Chase-and-escape motion,which is a typical behavior between a predator and prey,is an important dynamics in animate systems.It has been concerned recently in optics aiming for achieving novel light steering and switching functions.However,this optical counterpart can be realized in only one dimension because of the challenges in maintaining the chase-and-escape interaction.Herein,we report,both theoretically and experimentally,the optical predator-prey dynamics in two dimensions for the first time.Upon nonreciprocal interaction,two beams can form a localized or oblique spiral chase-and-escape motion,which persists owing to the mutual light confinement.Unusual optical phenomena are observed in these dynamics:the angular momentum is not conserved and the resulting transverse traveling motion can be opposite to the applied initial momentum and enhanced by increasing the internal light interactions.The results can inspire further fundamental studies by exploring analogous animate phenomena in optics that are potentially useful for developing optical intelligence functions.
基金Supported by National Key R&D Program of China(grant No.2023YFA1608304)Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0550103)National Natural Science Foundation of China(NSFC,grant No.11903054)。
文摘The SiTian Project represents a groundbreaking initiative in astronomy,aiming to deploy a global network of telescopes,each with a 1 m aperture,for comprehensive time-domain sky surveys.The network's innovative architecture features multiple observational nodes,each comprising three strategically aligned telescopes equipped with filters.This design enables three-color(g,r,i)channel imaging within each node,facilitating precise and coordinated observations.As a pathfinder to the full-scale project,the Mini-SiTian Project serves as the scientific and technological validation platform,utilizing three 30 cm aperture telescopes to validate the methodologies and technologies planned for the broader SiTian network.This paper focuses on the development and implementation of the Master Control System(MCS),and the central command hub for the Mini-SiTian Array.The MCS is designed to facilitate seamless communication with the SiTian Brain,the project's central processing and decisionmaking unit,while ensuring accurate task allocation,real-time status monitoring,and optimized observational workflows.The system adopts a robust architecture that separates front-end and back-end functionalities.A key innovation of the MCS is its ability to dynamically adjust observation plans in response to transient source alerts,enabling rapid and coordinated scans of target sky regions.The paper provides an in-depth analysis of the system's internal components,including the communication system,which is critical for seamless network operation.Extensive testing has validated the functionality,reliability,and compatibility of these components within the overall system architecture.The successful deployment of the MCS in managing the Mini-SiTian Array has demonstrated its practicality and efficacy in collaborative observation and distributed control.By simplifying cluster management and ensuring data integrity,the MCS represents a significant advancement in astronomical observation control systems.Its scalable and adaptable design not only supports the future expansion of the SiTian network but also provides a blueprint for other large-scale telescope arrays,marking a transformative step forward in time-domain astronomy.
