Four new sesquiterpenoids(1-4), including the first reported instance of a novel 2,3-seco oplopane carbon skeleton(1), together with 19 known analogues, were isolated from the flower buds of Tussilago farfara(coltsfoo...Four new sesquiterpenoids(1-4), including the first reported instance of a novel 2,3-seco oplopane carbon skeleton(1), together with 19 known analogues, were isolated from the flower buds of Tussilago farfara(coltsfoot). The challenging determination of relative and absolute configurations—particularly in flexible side chains and substituents—was achieved for the first time through an integrated approach combining spectroscopic analyses, chemical derivatization, chiral gas chromatography(GC), and quantum chemical calculations. All compounds were evaluated for anti-diabetic activity using an insulin-stimulated glucose uptake model in C2C12 myotubes and for anti-inflammatory activity via a lipopolysaccharide(LPS)-induced nitric oxide(NO) inhibition assay in RAW264.7 macrophages. Six compounds significantly enhanced glucose uptake, and mechanistic investigation of compound 3 revealed activation of the insulin receptor substrate 1(IRS-1)/protein kinase B(Akt)/glycogen synthase kinase 3β(GSK-3β) signaling pathway. Twenty-one compounds exhibited marked inhibition of NO production;among them, compounds 2 and 6 dose-dependently suppressed inducible nitric oxide synthase(iNOS) expression and nuclear factor κB(NF-κB) phosphorylation.展开更多
Under complex working conditions,accurate prediction of the remaining useful life(RUL)of lithium-ion batteries is of great significance to ensure the stable operation of energy storage systems,the safe driving of elec...Under complex working conditions,accurate prediction of the remaining useful life(RUL)of lithium-ion batteries is of great significance to ensure the stable operation of energy storage systems,the safe driving of electric vehicles,and the continuous power supply of electronic devices.This paper systematically describes the RUL prediction methods of lithium-ion batteries and comprehensively summarizes the development status and future trends in this field.First,the battery degradation mechanisms and lightweight data acquisition are analyzed.Secondly,a systematic classification model is constructed for the more widely used lithium battery RUL prediction methods,and the application characteristics and implementation limitations of different methods are analyzed in detail.An innovative classification framework for hybrid methods is proposed based on the depth of physical-data interaction.Then,collaborative modelling of calendar ageing and cyclic ageing is discussed,revealing their coupled effects and corresponding RUL prediction methods.Finally,the technical bottlenecks faced by the current RUL prediction of lithium batteries are identified,potential solutions are proposed,and the future development trends are outlined.展开更多
Objective:For patients with hypertension complicated with diabetes mellitus,their health risks are not a simple sum but present complex interactive effects.Clarifying the clinical characteristics of such patients is t...Objective:For patients with hypertension complicated with diabetes mellitus,their health risks are not a simple sum but present complex interactive effects.Clarifying the clinical characteristics of such patients is the key to solving this medical problem.Methods:From June 2023 to June 2024,this study conducted a comparative study on 100 patients with hypertension complicated with diabetes mellitus and 100 patients with hypertension alone.By retrospectively analyzing clinical data of patients,the differences in disease manifestations,complication occurrence,and treatment effects between the two groups were explored in depth,and the unique challenges and treatment difficulties faced by patients with hypertension complicated with diabetes mellitus were identified.Results:Hypertensive patients with concurrent diabetes had more difficult blood glucose and blood pressure control,and were more prone to severe complications such as cardiovascular lesions and renal damage.Conclusion:The clinical characteristics and treatment needs of patients with hypertension complicated with diabetes mellitus are different from those with hypertension alone,and disease management should be more refined and personalized.展开更多
The intestine is a key component of the barrier,absorption,and immune systems,contributing significantly to maintaining internal homeostasis and influencing disease progression.Its distinctive physiological functions ...The intestine is a key component of the barrier,absorption,and immune systems,contributing significantly to maintaining internal homeostasis and influencing disease progression.Its distinctive physiological functions arise from a complex interplay between its structure and microenvironment.Recent advancements in bioengineering technologies now enable the construction of in vitro intestinal models that faithfully recapitulate the organizational and functional characteristics of native tissue.This review examines the interface between in vitro models and native intestinal biology,offering insights into the replication of organ functions from a manufacturing perspective.We explore bioengineering strategies that enable the mapping of cross-scale structures and the creation of biomimetic environments essential for physiological performance.Furthermore,we discuss pragmatic optimization strategies for applying these models to both physiological and pathological studies,thereby enhancing their translational potential for drug development,disease modeling,and personalized medicine.In contrast to previous reviews,this work proposes an engineering-centered framework for linking structural fabrication strategies to functional performance across intestinal model types.展开更多
OBJECTIVE:To assess the efficacy of point application therapy(PAT)in alleviating the exacerbation of chronic respiratory diseases represented by bronchial asthma.METHODS:In this multicenter randomized placebocontrolle...OBJECTIVE:To assess the efficacy of point application therapy(PAT)in alleviating the exacerbation of chronic respiratory diseases represented by bronchial asthma.METHODS:In this multicenter randomized placebocontrolled trial,eligible bronchial asthma patients received placebo PAT on the dog days of the first summer to establish a baseline,and then patients who continued to participate in the trial and repassed the eligibility review were randomized to receive regular or placebo PAT in the next two consecutive summers.The primary outcome was the change from baseline in the number of asthma exacerbations at 24 months.Secondary outcomes included severity of asthma exacerbation,asthma control test(ACT)score,percentage of forced expiratory volume in 1 s(FEV1)to the predicated value(FEV1%pred),peak expiratory flow(PEF),ratio of FEV1 to forced vital capacity(FEV1/FVC),and use of palliative drugs during bronchial asthma exacerbations at 12 and 24 months.The adverse events(AEs)were also assessed.RESULTS:A total of 835 patients with bronchial asthma were randomized in this trial.Compared with the placebo control,the PAT significantly decreased the mean number of asthma exacerbations(1.42;95%confidence interval,0.69 to 2.14;P<0.001),and increased the FEV1%pred at 24 months(P=0.039)and FEV1/FVC at 12 months(P=0.01)and 24 months(P=0.01).There were no significant differences between the groups in PEF or ACT score at 12 and 24 months,or in FEV1%pred at 12 months.Treatment-related AEs were mild and more common in the PAT group than in the placebo PAT group.No serious AEs were reported.CONCLUSION:PAT conducted on dog days could reduce asthma exacerbations in patients with bronchial asthma.展开更多
AIM:To define the prevalence and anatomical patterns of paranasal sinus abnormalities(PSA)in thyroid-associated ophthalmopathy(TAO)and to test the hypothesis that TAO is partially driven by contiguous orbital inflamma...AIM:To define the prevalence and anatomical patterns of paranasal sinus abnormalities(PSA)in thyroid-associated ophthalmopathy(TAO)and to test the hypothesis that TAO is partially driven by contiguous orbital inflammation rather than systemic autoimmunity or generalized orbital pressure.METHODS:Data included ophthalmic assessments and a panel of thyroid function and autoimmune biomarkers.Blinded radiological analysis of orbital computed tomography(CT)scans was performed to quantify sinus abnormalities and extraocular muscles(EOMs)involvement.Patients were categorized into two groups based on CT findings,those with no radiological evidence of sinus abnormalities(non-PSA control group)and those with identifiable PSA.Furthermore,ethmoid sinus mucosal biopsies from a subset of TAO patients and noninflammatory controls were subjected to histopathological analysis.RESULTS:Totally 121 TAO patients(mean age 42.4±12.8y,range 10-78y),male:female=42:79,were included.PSA was identified in 44.6%(n=54)of patients,with a distribution anatomically restricted to the maxillary(50.0%isolated)and ethmoid sinuses(18.5%isolated;29.6%combined).Compared to the non-PSA group(n=67),patients with PSA were significantly older(45.1±11.8 vs 40.3±13.2y;P=0.040)and were more likely to be male(55.6%vs 17.9%;P<0.001).They also had significantly higher proptosis(22.1±3.2 vs 20.7±2.9 mm;P<0.001).Medial/inferior rectus involvement was most frequent(88.4%vs 89.3%).Histopathological analysis of sinus mucosa from PSA patients provided direct evidence of pathology,revealing a dense,chronic lymphoplasmacytic infiltrate and submucosal edema,validating the radiological findings as a true inflammatory process.No significant correlation was found with systemic autoimmune markers,including thyroid-stimulating hormone(TSH)receptor antibodies(TRAb,median 4.86 vs 2.71 IU/L,P=0.104).CONCLUSION:TAO is associated with a high prevalence of PSA in a pattern consistent with the orbital anatomy.The correlation with ipsilateral muscle thickening combined with the lack of association with proptosis laterality or systemic biomarkers lend strong support to a model of contiguous inflammation over systemic autoimmunity,a hypothesis that warrants further validation through longitudinal and mechanistic studies.展开更多
Purpose-Amidst an increasingly severe cybersecurity landscape,the widespread adoption of Xinchuang endpoints has become a strategic imperative.Governments and enterprises have established terminal localization as a cr...Purpose-Amidst an increasingly severe cybersecurity landscape,the widespread adoption of Xinchuang endpoints has become a strategic imperative.Governments and enterprises have established terminal localization as a critical objective,aiming for comprehensive indigenous replacement through rapid technological iteration.Consequently,Xinchuang systems and Windows platforms are expected to coexist over an extended period.This study seeks to establish an automated verification framework for multi-version operating systems and validate the efficacy of baseline hardening in mitigating security risks.Design/methodology/approach-Based on the Classified Protection 2.0 framework and relevant national standards for endpoint security,this study proposes an endpoint security baseline verification scheme applicable to multiple operating systems.The scheme addresses divergent security policies and implementation methodologies across heterogeneous environments.It automates the inspection of core baselines,including account password complexity,default shared service status and patch installation status.Furthermore,a comprehensive scoring model is established by incorporating differentiated weights for account security,patch management and log auditing,ultimately generating visualized risk reports to facilitate remediation prioritization.Findings-This study reveals that baseline configuration serves as the fundamental prerequisite in endpoint security practices.Through a scalable detection engine and quantitative scoring model,the system can promptly identify and remediate potential risks,thereby reducing the attack surface and mitigating intrusion risks.However,on certain domestic chip architectures,compatibility issues persist in detecting specific configuration items.Further improvement in hardware-software co-adaptation for domestic platforms is required to advance the development of localized security protection systems.Originality/value-Through in-depth research on security baseline configurations across multiple operating systems,this study implements an automated and visualized baseline verification methodology.This approach significantly strengthens the security posture of domestic operating systems and supports the establishment of a more robust,national-level cybersecurity defense framework.展开更多
Solar-blind ultraviolet photodetectors(UV PDs),capable of detecting UV radiation without interference from sun-light,have attracted significant interest.Herein,we propose a 0D/1D heterostructure for UV PDs,which was f...Solar-blind ultraviolet photodetectors(UV PDs),capable of detecting UV radiation without interference from sun-light,have attracted significant interest.Herein,we propose a 0D/1D heterostructure for UV PDs,which was fabricated by spin-coating MoS_(2)quantum dots onto p-AlGaN nanowires.The device achieves a high responsivity of 175.5 mA/W and a fast response speed of 83 ms at 250 nm illumination under self-powered mode,which improved nearly 1235%and 521%after MoS_(2)decoration,respectively.These improvements can be attributed to the type-Ⅱheterostructure formed between p-AlGaN and MoS_(2),which facilitates enhanced charge separation and carrier transport.Later,we demonstrate the implementation of this device in optical communication,achieving high-accuracy transmission of"GaN"ASCII code signals.Such a 0D/1D het-erostructure provides an effective strategy for high-performance solar-blind UV PD.展开更多
糖分积累是决定园艺作物果实品质的关键因素之一,而糖转运蛋白在糖分运输和分配过程中发挥着核心作用。近年来,随着分子生物学技术的发展,糖转运蛋白在调控果实糖分积累和品质形成中的分子机制研究取得了重要进展。本文简述了SWEET(suga...糖分积累是决定园艺作物果实品质的关键因素之一,而糖转运蛋白在糖分运输和分配过程中发挥着核心作用。近年来,随着分子生物学技术的发展,糖转运蛋白在调控果实糖分积累和品质形成中的分子机制研究取得了重要进展。本文简述了SWEET(sugars will eventually be exported transporters)、SUT(sucrose transporters)和TST(tonoplast sugar transporter)三大类糖转运蛋白家族的结构特征、表达模式及其在果实发育过程中的功能,重点阐述了糖转运蛋白通过调控糖分卸载、转运和储存影响果实糖分积累的分子机制,探讨了环境因素、激素信号和表观遗传修饰对糖转运蛋白功能的调控作用,并展望了通过调控糖转运蛋白改良果实品质的分子育种策略。最后,提出了该领域尚未解决的科学问题及未来研究方向,为深入理解果实品质形成的分子基础和提高果实品质提供理论依据。展开更多
Carbon capture,utilization,and storage(CCUS)represents a critical technological pathway for global car-bon emission reduction.CCUS-enhanced oil recovery(EOR)technology is the most feasible CCUS technol-ogy demonstrati...Carbon capture,utilization,and storage(CCUS)represents a critical technological pathway for global car-bon emission reduction.CCUS-enhanced oil recovery(EOR)technology is the most feasible CCUS technol-ogy demonstrating dual benefits of enhanced energy production and carbon reduction.This study comprehensively described the key influencing factors governing CO_(2)-EOR and geological storage and systematically analyzed reservoir properties,fluid characteristics,and operational parameters.The mech-anisms of these parameters on EOR versus CO_(2) storage performance were investigated throughout CCUS-EOR processes.This paper proposes a coupled two-stage CCUS-EOR process:CO_(2)-EOR storage stage and long-term CO_(2) storage stage after the CO_(2) injection phase is completed.In each stage,the main control factors impacting the CO_(2)-EOR and storage stages are screened and coupled with rigorous technical anal-ysis.The key factors here are reservoir properties,fluid characteristics,and operational parameter.A novel CCUS-EOR synergistic method was proposed to optimize the lifecycle performance of dual objective of EOR and storage.Furthermore,based on multi-objective optimization,considering the lifecycle,a multi-scale techno-economic evaluation method was proposed to fully assess the CCUS-EOR project per-formance.Finally,a set of recommendations for advancing CCUS-EOR technologies by deploying multi-factor/multi-field coupling methodologies,novel green intelligent injection materials,and artificial intel-ligence/machine learning technologies were visited.展开更多
Acupuncture-moxibustion can promote recovery from the sequelae of ischemic stroke.However,its mechanism of action has not yet been fully elucidated.This paper introduces the mechanism of acupuncture-moxibustion in all...Acupuncture-moxibustion can promote recovery from the sequelae of ischemic stroke.However,its mechanism of action has not yet been fully elucidated.This paper introduces the mechanism of acupuncture-moxibustion in alleviating rehabilitation of ischemic stroke sequelae.The regulatory mechanism of acupuncture-moxibustion was analyzed for limb movement disorders,cognitive impairment,depression,epilepsy,dysphagia,and insomnia after stroke from four aspects(promoting neuronal growth and cell proliferation,regulating cerebral blood flow,modulating neurochemicals,and suppressing cell apoptosis).This study provides theoretical support for the wide application of acupuncture-moxibustion in rehabilitation after ischemic stroke.展开更多
Osteomyelitis remains a global challenge in the field of orthopedics.Even after standard debridement and antibiotic-assisted treatment,the long-term recurrence rate remains at 20%-30%.Given the dynamic changes in immu...Osteomyelitis remains a global challenge in the field of orthopedics.Even after standard debridement and antibiotic-assisted treatment,the long-term recurrence rate remains at 20%-30%.Given the dynamic changes in immune responses and defense mechanisms during bone infection,as well as the complex“race for the surface”involving bacterial adhesion and host cells(macrophages and tissue cells)on implant surfaces,biomaterials with immunomodulatory functions have attracted considerable attention.Macrophages,as crucial components of the immune system,participate in the inflammatory regulation and tissue remodeling of bone infections through highly plastic polarization mechanisms after bacterial invasion.The different microenvironmental characteristics and therapeutic needs at different stages of bone infection highlight the promising applications of biomaterials capable of macrophage polarization remodeling and sequential regulation.In this review,we provide a detailed discussion of the complex immune regulatory patterns in the bone infection microenvironment and the critical functions of macrophage polarization.We then explore how implant surface properties influence bacterial adhesion and macrophage function,highlighting the importance of achieving precise and dynamic regulation of macrophage polarization based on the Race for the Surface theory.Furthermore,we focus on recent advances,potential challenges,and opportunities in biomaterial-mediated macrophage polarization remodeling and sequential modulation strategies across different stages of osteomyelitis,aiming to offer insights that may accelerate the clinical translation of novel biomaterial-based macrophage immunotherapies.展开更多
基金supported by the National Natural Science Foundation of China (No. 22077111)the Department of Education of Guangdong Province (No. 2022ZDJS025)+1 种基金the Hong Kong/Macao Joint Research and Development Fund Project of Wuyi University (No. 2022WGALH15)Zhejiang Medical and Health Science and Technology Plan Project of China (No.2022KY231)。
文摘Four new sesquiterpenoids(1-4), including the first reported instance of a novel 2,3-seco oplopane carbon skeleton(1), together with 19 known analogues, were isolated from the flower buds of Tussilago farfara(coltsfoot). The challenging determination of relative and absolute configurations—particularly in flexible side chains and substituents—was achieved for the first time through an integrated approach combining spectroscopic analyses, chemical derivatization, chiral gas chromatography(GC), and quantum chemical calculations. All compounds were evaluated for anti-diabetic activity using an insulin-stimulated glucose uptake model in C2C12 myotubes and for anti-inflammatory activity via a lipopolysaccharide(LPS)-induced nitric oxide(NO) inhibition assay in RAW264.7 macrophages. Six compounds significantly enhanced glucose uptake, and mechanistic investigation of compound 3 revealed activation of the insulin receptor substrate 1(IRS-1)/protein kinase B(Akt)/glycogen synthase kinase 3β(GSK-3β) signaling pathway. Twenty-one compounds exhibited marked inhibition of NO production;among them, compounds 2 and 6 dose-dependently suppressed inducible nitric oxide synthase(iNOS) expression and nuclear factor κB(NF-κB) phosphorylation.
基金supported by the National Natural Science Foundation of China(No.U23A20651)the Central Government Guides Local Science and Technology Development Foundation(No.2023ZYDF022)+1 种基金the Sichuan Science and Technology Program(2024ZDZX0031)the Open Fund Project of State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines(No.SKLMRDPC23KF19).
文摘Under complex working conditions,accurate prediction of the remaining useful life(RUL)of lithium-ion batteries is of great significance to ensure the stable operation of energy storage systems,the safe driving of electric vehicles,and the continuous power supply of electronic devices.This paper systematically describes the RUL prediction methods of lithium-ion batteries and comprehensively summarizes the development status and future trends in this field.First,the battery degradation mechanisms and lightweight data acquisition are analyzed.Secondly,a systematic classification model is constructed for the more widely used lithium battery RUL prediction methods,and the application characteristics and implementation limitations of different methods are analyzed in detail.An innovative classification framework for hybrid methods is proposed based on the depth of physical-data interaction.Then,collaborative modelling of calendar ageing and cyclic ageing is discussed,revealing their coupled effects and corresponding RUL prediction methods.Finally,the technical bottlenecks faced by the current RUL prediction of lithium batteries are identified,potential solutions are proposed,and the future development trends are outlined.
文摘Objective:For patients with hypertension complicated with diabetes mellitus,their health risks are not a simple sum but present complex interactive effects.Clarifying the clinical characteristics of such patients is the key to solving this medical problem.Methods:From June 2023 to June 2024,this study conducted a comparative study on 100 patients with hypertension complicated with diabetes mellitus and 100 patients with hypertension alone.By retrospectively analyzing clinical data of patients,the differences in disease manifestations,complication occurrence,and treatment effects between the two groups were explored in depth,and the unique challenges and treatment difficulties faced by patients with hypertension complicated with diabetes mellitus were identified.Results:Hypertensive patients with concurrent diabetes had more difficult blood glucose and blood pressure control,and were more prone to severe complications such as cardiovascular lesions and renal damage.Conclusion:The clinical characteristics and treatment needs of patients with hypertension complicated with diabetes mellitus are different from those with hypertension alone,and disease management should be more refined and personalized.
基金the support from the National Key Research and Development Program of China(Nos.2024YFB4607700 and 2018YFA0703000)the Natural Science Foundation of Zhejiang Province(Nos.LDQ23E050001 and LQ24H260006)+2 种基金the National Natural Science Foundation of China(Nos.62303290,52305325,and 52405305)Shanghai Magnolia Talent Program Pujiang Project(No.23PJD036)The project was also supported by the State Key Laboratory of Materials Processing and Die&Mould Technology,Huazhong University of Science and Technology(No.P2025-002).
文摘The intestine is a key component of the barrier,absorption,and immune systems,contributing significantly to maintaining internal homeostasis and influencing disease progression.Its distinctive physiological functions arise from a complex interplay between its structure and microenvironment.Recent advancements in bioengineering technologies now enable the construction of in vitro intestinal models that faithfully recapitulate the organizational and functional characteristics of native tissue.This review examines the interface between in vitro models and native intestinal biology,offering insights into the replication of organ functions from a manufacturing perspective.We explore bioengineering strategies that enable the mapping of cross-scale structures and the creation of biomimetic environments essential for physiological performance.Furthermore,we discuss pragmatic optimization strategies for applying these models to both physiological and pathological studies,thereby enhancing their translational potential for drug development,disease modeling,and personalized medicine.In contrast to previous reviews,this work proposes an engineering-centered framework for linking structural fabrication strategies to functional performance across intestinal model types.
基金Supported by“12th Five-year” National Science and Technology Pillar Program by the Ministry of Science and Technology of the People’s Republic of China:Clinical Evaluation and Technical Operation Specification Research on Preventing Bronchial Asthma Attacks by Acupoint Application in Winter Disease Summer Treatment(No. 2015BAI04B11)。
文摘OBJECTIVE:To assess the efficacy of point application therapy(PAT)in alleviating the exacerbation of chronic respiratory diseases represented by bronchial asthma.METHODS:In this multicenter randomized placebocontrolled trial,eligible bronchial asthma patients received placebo PAT on the dog days of the first summer to establish a baseline,and then patients who continued to participate in the trial and repassed the eligibility review were randomized to receive regular or placebo PAT in the next two consecutive summers.The primary outcome was the change from baseline in the number of asthma exacerbations at 24 months.Secondary outcomes included severity of asthma exacerbation,asthma control test(ACT)score,percentage of forced expiratory volume in 1 s(FEV1)to the predicated value(FEV1%pred),peak expiratory flow(PEF),ratio of FEV1 to forced vital capacity(FEV1/FVC),and use of palliative drugs during bronchial asthma exacerbations at 12 and 24 months.The adverse events(AEs)were also assessed.RESULTS:A total of 835 patients with bronchial asthma were randomized in this trial.Compared with the placebo control,the PAT significantly decreased the mean number of asthma exacerbations(1.42;95%confidence interval,0.69 to 2.14;P<0.001),and increased the FEV1%pred at 24 months(P=0.039)and FEV1/FVC at 12 months(P=0.01)and 24 months(P=0.01).There were no significant differences between the groups in PEF or ACT score at 12 and 24 months,or in FEV1%pred at 12 months.Treatment-related AEs were mild and more common in the PAT group than in the placebo PAT group.No serious AEs were reported.CONCLUSION:PAT conducted on dog days could reduce asthma exacerbations in patients with bronchial asthma.
基金Supported by The National Natural Science Foundation of China(No.82101180)the Fund for Beijing Science&Technology Development of TCM(No.BJZYYB-2023-17)the Beijing Municipal Natural Science Foundation grant(No.7252093).
文摘AIM:To define the prevalence and anatomical patterns of paranasal sinus abnormalities(PSA)in thyroid-associated ophthalmopathy(TAO)and to test the hypothesis that TAO is partially driven by contiguous orbital inflammation rather than systemic autoimmunity or generalized orbital pressure.METHODS:Data included ophthalmic assessments and a panel of thyroid function and autoimmune biomarkers.Blinded radiological analysis of orbital computed tomography(CT)scans was performed to quantify sinus abnormalities and extraocular muscles(EOMs)involvement.Patients were categorized into two groups based on CT findings,those with no radiological evidence of sinus abnormalities(non-PSA control group)and those with identifiable PSA.Furthermore,ethmoid sinus mucosal biopsies from a subset of TAO patients and noninflammatory controls were subjected to histopathological analysis.RESULTS:Totally 121 TAO patients(mean age 42.4±12.8y,range 10-78y),male:female=42:79,were included.PSA was identified in 44.6%(n=54)of patients,with a distribution anatomically restricted to the maxillary(50.0%isolated)and ethmoid sinuses(18.5%isolated;29.6%combined).Compared to the non-PSA group(n=67),patients with PSA were significantly older(45.1±11.8 vs 40.3±13.2y;P=0.040)and were more likely to be male(55.6%vs 17.9%;P<0.001).They also had significantly higher proptosis(22.1±3.2 vs 20.7±2.9 mm;P<0.001).Medial/inferior rectus involvement was most frequent(88.4%vs 89.3%).Histopathological analysis of sinus mucosa from PSA patients provided direct evidence of pathology,revealing a dense,chronic lymphoplasmacytic infiltrate and submucosal edema,validating the radiological findings as a true inflammatory process.No significant correlation was found with systemic autoimmune markers,including thyroid-stimulating hormone(TSH)receptor antibodies(TRAb,median 4.86 vs 2.71 IU/L,P=0.104).CONCLUSION:TAO is associated with a high prevalence of PSA in a pattern consistent with the orbital anatomy.The correlation with ipsilateral muscle thickening combined with the lack of association with proptosis laterality or systemic biomarkers lend strong support to a model of contiguous inflammation over systemic autoimmunity,a hypothesis that warrants further validation through longitudinal and mechanistic studies.
基金supported by scientific research projects of China Academy of Railway Sciences Co.,Ltd.(grant no.2024YJ117).
文摘Purpose-Amidst an increasingly severe cybersecurity landscape,the widespread adoption of Xinchuang endpoints has become a strategic imperative.Governments and enterprises have established terminal localization as a critical objective,aiming for comprehensive indigenous replacement through rapid technological iteration.Consequently,Xinchuang systems and Windows platforms are expected to coexist over an extended period.This study seeks to establish an automated verification framework for multi-version operating systems and validate the efficacy of baseline hardening in mitigating security risks.Design/methodology/approach-Based on the Classified Protection 2.0 framework and relevant national standards for endpoint security,this study proposes an endpoint security baseline verification scheme applicable to multiple operating systems.The scheme addresses divergent security policies and implementation methodologies across heterogeneous environments.It automates the inspection of core baselines,including account password complexity,default shared service status and patch installation status.Furthermore,a comprehensive scoring model is established by incorporating differentiated weights for account security,patch management and log auditing,ultimately generating visualized risk reports to facilitate remediation prioritization.Findings-This study reveals that baseline configuration serves as the fundamental prerequisite in endpoint security practices.Through a scalable detection engine and quantitative scoring model,the system can promptly identify and remediate potential risks,thereby reducing the attack surface and mitigating intrusion risks.However,on certain domestic chip architectures,compatibility issues persist in detecting specific configuration items.Further improvement in hardware-software co-adaptation for domestic platforms is required to advance the development of localized security protection systems.Originality/value-Through in-depth research on security baseline configurations across multiple operating systems,this study implements an automated and visualized baseline verification methodology.This approach significantly strengthens the security posture of domestic operating systems and supports the establishment of a more robust,national-level cybersecurity defense framework.
基金supported in part by the National Natural Science Foundation of China(Grant Nos.52272168 and 62322410)the Anhui Provincial Natural Science Foundation(Grant No.2308085J08)USTC Bihe Youth Program for Interdisciplinary Innovation(Grant No.BH-202514).
文摘Solar-blind ultraviolet photodetectors(UV PDs),capable of detecting UV radiation without interference from sun-light,have attracted significant interest.Herein,we propose a 0D/1D heterostructure for UV PDs,which was fabricated by spin-coating MoS_(2)quantum dots onto p-AlGaN nanowires.The device achieves a high responsivity of 175.5 mA/W and a fast response speed of 83 ms at 250 nm illumination under self-powered mode,which improved nearly 1235%and 521%after MoS_(2)decoration,respectively.These improvements can be attributed to the type-Ⅱheterostructure formed between p-AlGaN and MoS_(2),which facilitates enhanced charge separation and carrier transport.Later,we demonstrate the implementation of this device in optical communication,achieving high-accuracy transmission of"GaN"ASCII code signals.Such a 0D/1D het-erostructure provides an effective strategy for high-performance solar-blind UV PD.
文摘糖分积累是决定园艺作物果实品质的关键因素之一,而糖转运蛋白在糖分运输和分配过程中发挥着核心作用。近年来,随着分子生物学技术的发展,糖转运蛋白在调控果实糖分积累和品质形成中的分子机制研究取得了重要进展。本文简述了SWEET(sugars will eventually be exported transporters)、SUT(sucrose transporters)和TST(tonoplast sugar transporter)三大类糖转运蛋白家族的结构特征、表达模式及其在果实发育过程中的功能,重点阐述了糖转运蛋白通过调控糖分卸载、转运和储存影响果实糖分积累的分子机制,探讨了环境因素、激素信号和表观遗传修饰对糖转运蛋白功能的调控作用,并展望了通过调控糖转运蛋白改良果实品质的分子育种策略。最后,提出了该领域尚未解决的科学问题及未来研究方向,为深入理解果实品质形成的分子基础和提高果实品质提供理论依据。
基金the financial support from the National Key Research and Development Program of China(2022YFE0206700)the Science Foundation of China University of Petroleum,Beijing(2462021YJRC012).
文摘Carbon capture,utilization,and storage(CCUS)represents a critical technological pathway for global car-bon emission reduction.CCUS-enhanced oil recovery(EOR)technology is the most feasible CCUS technol-ogy demonstrating dual benefits of enhanced energy production and carbon reduction.This study comprehensively described the key influencing factors governing CO_(2)-EOR and geological storage and systematically analyzed reservoir properties,fluid characteristics,and operational parameters.The mech-anisms of these parameters on EOR versus CO_(2) storage performance were investigated throughout CCUS-EOR processes.This paper proposes a coupled two-stage CCUS-EOR process:CO_(2)-EOR storage stage and long-term CO_(2) storage stage after the CO_(2) injection phase is completed.In each stage,the main control factors impacting the CO_(2)-EOR and storage stages are screened and coupled with rigorous technical anal-ysis.The key factors here are reservoir properties,fluid characteristics,and operational parameter.A novel CCUS-EOR synergistic method was proposed to optimize the lifecycle performance of dual objective of EOR and storage.Furthermore,based on multi-objective optimization,considering the lifecycle,a multi-scale techno-economic evaluation method was proposed to fully assess the CCUS-EOR project per-formance.Finally,a set of recommendations for advancing CCUS-EOR technologies by deploying multi-factor/multi-field coupling methodologies,novel green intelligent injection materials,and artificial intel-ligence/machine learning technologies were visited.
基金Supported by Traditional Chinese Medicine Research Project of Heilongjiang Province:ZHY2020-062.
文摘Acupuncture-moxibustion can promote recovery from the sequelae of ischemic stroke.However,its mechanism of action has not yet been fully elucidated.This paper introduces the mechanism of acupuncture-moxibustion in alleviating rehabilitation of ischemic stroke sequelae.The regulatory mechanism of acupuncture-moxibustion was analyzed for limb movement disorders,cognitive impairment,depression,epilepsy,dysphagia,and insomnia after stroke from four aspects(promoting neuronal growth and cell proliferation,regulating cerebral blood flow,modulating neurochemicals,and suppressing cell apoptosis).This study provides theoretical support for the wide application of acupuncture-moxibustion in rehabilitation after ischemic stroke.
基金supported by National Natural Science Foundation of China(Grant No.82072392)Yunnan Orthopedics and Sports Rehabilitation Clinical Medicine Research Center(Grant No.202102AA310068)+2 种基金Yunnan Clinical Medical Center for Traumatology and Orthopedics(Grant No.ZX20191001)Basic research project of Science and Technology Department of Yunnan Province(Grant No.202301AC070621)Scientific Research Fund Project Department of Education of Yunnan Province(Grant No.2024Y251)。
文摘Osteomyelitis remains a global challenge in the field of orthopedics.Even after standard debridement and antibiotic-assisted treatment,the long-term recurrence rate remains at 20%-30%.Given the dynamic changes in immune responses and defense mechanisms during bone infection,as well as the complex“race for the surface”involving bacterial adhesion and host cells(macrophages and tissue cells)on implant surfaces,biomaterials with immunomodulatory functions have attracted considerable attention.Macrophages,as crucial components of the immune system,participate in the inflammatory regulation and tissue remodeling of bone infections through highly plastic polarization mechanisms after bacterial invasion.The different microenvironmental characteristics and therapeutic needs at different stages of bone infection highlight the promising applications of biomaterials capable of macrophage polarization remodeling and sequential regulation.In this review,we provide a detailed discussion of the complex immune regulatory patterns in the bone infection microenvironment and the critical functions of macrophage polarization.We then explore how implant surface properties influence bacterial adhesion and macrophage function,highlighting the importance of achieving precise and dynamic regulation of macrophage polarization based on the Race for the Surface theory.Furthermore,we focus on recent advances,potential challenges,and opportunities in biomaterial-mediated macrophage polarization remodeling and sequential modulation strategies across different stages of osteomyelitis,aiming to offer insights that may accelerate the clinical translation of novel biomaterial-based macrophage immunotherapies.
