The fasting evolving information technology has driven the global industry into a new period of development where integration of informatization and industrialization became the focus of all countries around the world...The fasting evolving information technology has driven the global industry into a new period of development where integration of informatization and industrialization became the focus of all countries around the world,and a key trend for thousands of enterprises to follow.This now plays a decisive role on the evolution of world’s industrial development as well as the international competition.展开更多
In the evening of October 17, 2012, the vessel Hangjun 12 of Changhang Wuhan Engineering Bureau was struck by lightning when working in Malaysia red ridge channel. In the lightning accident, the weather instrument of ...In the evening of October 17, 2012, the vessel Hangjun 12 of Changhang Wuhan Engineering Bureau was struck by lightning when working in Malaysia red ridge channel. In the lightning accident, the weather instrument of the ship was destroyed by the lightning to the ground, and the electronic information equipment in the vessel was influenced by induction lightning, which had damaged the electronic information system and elec- trical equipment. According to the Code for Design Protection of Structures against Lightning （ GB 50057-2010）, this lightning accident suffered by Hangjun 12 was analyzed theoretically from aspects of the protection scope of the two lightning reds, main measures against lightning electromag- netic impulse, and specific reasons for the lightning accident. Finally, some measures to prevent the ship from being struck by lightning were put forward, such as improving countermeasures against direct lightning flash, enhancing equipotential bonding and shielding measures and so forth.展开更多
多频高精度定位中需要考虑新频率对定位性能的影响。传统相位频间钟偏差(inter frequency clock bias,IFCB)处理方法受制于参考站数量,且与接收机和卫星相关的硬件延迟相关,影响多频精密单点定位(precision point positioning,PPP)的可...多频高精度定位中需要考虑新频率对定位性能的影响。传统相位频间钟偏差(inter frequency clock bias,IFCB)处理方法受制于参考站数量,且与接收机和卫星相关的硬件延迟相关,影响多频精密单点定位(precision point positioning,PPP)的可靠性和准确性。针对IFCB对多全球导航卫星系统(global navigation satellite system,GNSS)多频PPP的影响,本文提出了基于测站IFCB观测值提取功率谱密度(power spectral density,PSD)的算法,进一步构建IFCB参数时变特性约束的多频PPP算法,并全面分析了IFCB的时变特性和不同IFCB模型对非差非组合PPP性能的影响。试验结果表明:依据测站IFCB观测值提取IFCB功率谱密度可行且有效。相较于忽略IFCB方法,采用PSD约束的随机模型估计IFCB,PPP在收敛时间提升最大,提升46.51%,采用iGMAS产品和CNES产品平均提升43.54%、34.50%,三维定位精度分别提升41.68%、32.24%、24.64%。并且,将IFCB采用时变特性约束的随机模型参数优化方案能真实地反映IFCB变化。因此,在多GNSS多频PPP处理中,将IFCB参数采用时变特性约束的随机模型参数优化方案能够加快位置收敛速度,提升定位精度,优于产品改正方法,更有利于实时多频PPP的应用。展开更多
目的:基于网络药理学方法探讨丹参-牡丹皮配伍治疗膝骨性关节炎(knee osteoarthritis,KOA)的作用机制。方法:在中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCM...目的:基于网络药理学方法探讨丹参-牡丹皮配伍治疗膝骨性关节炎(knee osteoarthritis,KOA)的作用机制。方法:在中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)检索并筛选丹参-牡丹皮活性成分及相关靶点蛋白,利用UniPort数据库进行靶点蛋白名转化。构建丹参-牡丹皮活性成分-靶点网络。在人类基因数据库(the human gene database,GeneCards)、Disgenet数据库、在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)、药物靶标数据库(therapeutic targetdatabase,TTD)、DrugBank数据库检索KOA疾病相关靶点。筛选丹参-牡丹皮作用于KOA的活性成分靶点。利用Cytoscape 3.7.2软件及其插件Bisogenet、CytoNCA对靶点进行交集分析并构建蛋白-蛋白互作(protein-protein interactions,PPI)网络图。将直接作用靶点输入核心靶基因功能注释数据库(the database for annotation visualization and integrated discovery,DAVID)进行基因本体论(gene ontology,GO)功能和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。结果:筛选出丹参65个活性成分,牡丹皮11个活性成分。获得丹参靶点蛋白932个,牡丹皮靶点蛋白237个。通过UniPort数据库转化最终获得作用靶点214个。筛选出KOA疾病靶点1207个,得到药物与疾病共同作用靶点97个。IL-6、VEGF、TP53、ESR1、MMP、MYC、CXCL8、FOS、JUN、TNF等可能是丹参-牡丹皮治疗KOA的关键靶点;GO功能富集分析获得349个富集结果,其中包括分子功能、细胞组分、生物过程;KEGG通路富集分析获得90个相关通路。结论:丹参-牡丹皮的有效成分包括槲皮素、木樨草素等,它们通过作用于IL-6、VEGFA、TNF、MMP等靶点,主要介导MAPK信号通路,从而调控软骨细胞的凋亡与退变,减少细胞外基质的降解,抑制骨吸收,介导炎症反应,促进血管新生,加速炎症吸收和代谢分解,最终减缓软骨组织的病损进展,发挥抗KOA的治疗作用。展开更多
Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were studied.To illustrate the...Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were studied.To illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically calculated.The effect of precipitate ripening on the Goss texture and magnetic property was investigated.Data indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate increased.Secondary recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}<227>oriented grains growing abnormally and a magnetic induction intensity of 1.90T.Furthermore,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss texture.However,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 T.At a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this study.The heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.展开更多
文摘The fasting evolving information technology has driven the global industry into a new period of development where integration of informatization and industrialization became the focus of all countries around the world,and a key trend for thousands of enterprises to follow.This now plays a decisive role on the evolution of world’s industrial development as well as the international competition.
文摘In the evening of October 17, 2012, the vessel Hangjun 12 of Changhang Wuhan Engineering Bureau was struck by lightning when working in Malaysia red ridge channel. In the lightning accident, the weather instrument of the ship was destroyed by the lightning to the ground, and the electronic information equipment in the vessel was influenced by induction lightning, which had damaged the electronic information system and elec- trical equipment. According to the Code for Design Protection of Structures against Lightning （ GB 50057-2010）, this lightning accident suffered by Hangjun 12 was analyzed theoretically from aspects of the protection scope of the two lightning reds, main measures against lightning electromag- netic impulse, and specific reasons for the lightning accident. Finally, some measures to prevent the ship from being struck by lightning were put forward, such as improving countermeasures against direct lightning flash, enhancing equipotential bonding and shielding measures and so forth.
文摘目的:基于网络药理学方法探讨丹参-牡丹皮配伍治疗膝骨性关节炎(knee osteoarthritis,KOA)的作用机制。方法:在中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)检索并筛选丹参-牡丹皮活性成分及相关靶点蛋白,利用UniPort数据库进行靶点蛋白名转化。构建丹参-牡丹皮活性成分-靶点网络。在人类基因数据库(the human gene database,GeneCards)、Disgenet数据库、在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)、药物靶标数据库(therapeutic targetdatabase,TTD)、DrugBank数据库检索KOA疾病相关靶点。筛选丹参-牡丹皮作用于KOA的活性成分靶点。利用Cytoscape 3.7.2软件及其插件Bisogenet、CytoNCA对靶点进行交集分析并构建蛋白-蛋白互作(protein-protein interactions,PPI)网络图。将直接作用靶点输入核心靶基因功能注释数据库(the database for annotation visualization and integrated discovery,DAVID)进行基因本体论(gene ontology,GO)功能和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。结果:筛选出丹参65个活性成分,牡丹皮11个活性成分。获得丹参靶点蛋白932个,牡丹皮靶点蛋白237个。通过UniPort数据库转化最终获得作用靶点214个。筛选出KOA疾病靶点1207个,得到药物与疾病共同作用靶点97个。IL-6、VEGF、TP53、ESR1、MMP、MYC、CXCL8、FOS、JUN、TNF等可能是丹参-牡丹皮治疗KOA的关键靶点;GO功能富集分析获得349个富集结果,其中包括分子功能、细胞组分、生物过程;KEGG通路富集分析获得90个相关通路。结论:丹参-牡丹皮的有效成分包括槲皮素、木樨草素等,它们通过作用于IL-6、VEGFA、TNF、MMP等靶点,主要介导MAPK信号通路,从而调控软骨细胞的凋亡与退变,减少细胞外基质的降解,抑制骨吸收,介导炎症反应,促进血管新生,加速炎症吸收和代谢分解,最终减缓软骨组织的病损进展,发挥抗KOA的治疗作用。
文摘Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were studied.To illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically calculated.The effect of precipitate ripening on the Goss texture and magnetic property was investigated.Data indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate increased.Secondary recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}<227>oriented grains growing abnormally and a magnetic induction intensity of 1.90T.Furthermore,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss texture.However,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 T.At a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this study.The heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.
