If you've ever wondered how ancient emperors went about their royal celehrations during China's Spring Festival,an ongoing exhibition at the Forbidden City can provideyou with clues.The Beijing landmark,which ...If you've ever wondered how ancient emperors went about their royal celehrations during China's Spring Festival,an ongoing exhibition at the Forbidden City can provideyou with clues.The Beijing landmark,which houses the Palace Museum, was the imperial palace for the Ming (1368-1644)and Qing (1644-1911)dynasties.展开更多
铁是人体必须的微量元素,约70%存在于血红蛋白和肌红蛋白中,参与肌细胞多种生理过程,缺铁和铁超载都会引起骨骼肌萎缩。缺铁导致肌细胞生长停滞和死亡,缺铁后肌细胞中线粒体数量减少和功能下降导致肌细胞能量代谢紊乱。铁超载诱发肌细...铁是人体必须的微量元素,约70%存在于血红蛋白和肌红蛋白中,参与肌细胞多种生理过程,缺铁和铁超载都会引起骨骼肌萎缩。缺铁导致肌细胞生长停滞和死亡,缺铁后肌细胞中线粒体数量减少和功能下降导致肌细胞能量代谢紊乱。铁超载诱发肌细胞活性氧(reactive oxygen species,ROS)产生和脂质过氧化物反应,引起自由基产生增加损害脂质、蛋白质和核酸结构,导致肌细胞损伤和死亡。铁超载激活肌肉环指蛋白1(muscle ring finger 1,MuRF1)促进骨骼肌退化,抑制蛋白激酶B(proteinkinase B,Akt)/叉头框蛋白O1(forkhead box protein O1,FOXO1)信号通路,导致肌肉质量下降。运动后铁蛋白受体表达增加,肌肉对铁的摄取增加,并降低肌肉中铁蛋白水平,促进肠道对铁吸收和利用。因此,深入探究铁代谢异常与骨骼肌萎缩及其运动之间的关系,对于预防和治疗铁代谢异常诱发骨骼肌萎缩具有重要意义。展开更多
文摘If you've ever wondered how ancient emperors went about their royal celehrations during China's Spring Festival,an ongoing exhibition at the Forbidden City can provideyou with clues.The Beijing landmark,which houses the Palace Museum, was the imperial palace for the Ming (1368-1644)and Qing (1644-1911)dynasties.
文摘铁是人体必须的微量元素,约70%存在于血红蛋白和肌红蛋白中,参与肌细胞多种生理过程,缺铁和铁超载都会引起骨骼肌萎缩。缺铁导致肌细胞生长停滞和死亡,缺铁后肌细胞中线粒体数量减少和功能下降导致肌细胞能量代谢紊乱。铁超载诱发肌细胞活性氧(reactive oxygen species,ROS)产生和脂质过氧化物反应,引起自由基产生增加损害脂质、蛋白质和核酸结构,导致肌细胞损伤和死亡。铁超载激活肌肉环指蛋白1(muscle ring finger 1,MuRF1)促进骨骼肌退化,抑制蛋白激酶B(proteinkinase B,Akt)/叉头框蛋白O1(forkhead box protein O1,FOXO1)信号通路,导致肌肉质量下降。运动后铁蛋白受体表达增加,肌肉对铁的摄取增加,并降低肌肉中铁蛋白水平,促进肠道对铁吸收和利用。因此,深入探究铁代谢异常与骨骼肌萎缩及其运动之间的关系,对于预防和治疗铁代谢异常诱发骨骼肌萎缩具有重要意义。
