Background: Fibromuscular dysplasia (FMD) is a rare idiopathic segmental non-arteriosclerotic and non-inflammatory arterial disease of small to medium-sized vessels. Although it is considered a benign entity, FMD can ...Background: Fibromuscular dysplasia (FMD) is a rare idiopathic segmental non-arteriosclerotic and non-inflammatory arterial disease of small to medium-sized vessels. Although it is considered a benign entity, FMD can lead to potentially severe cerebrovascular complications. We present an atypical clinical case of ischemic stroke (IS) caused by bilateral carotid dissection revealing multifocal FMD. Case Report: A 43-year-old right-handed female with no medical history suddenly developed somnolence with left-sided weakness. Clinical examination revealed left hemiplegia and left central facial paralysis with an NIHSS score: 22. Cerebral tomography (CT) with arterial angiogram revealed abilateralis of the middle cerebral arteries (MCA), a double dissection of the internal carotids (IC), aneurysmal ectasia of the left IC, and aneurysm of the M2 segment of the MCA. Brain magnetic resonance imaging (MRI) with arterial angiography confirmed the bilateral dissection. A cerebral angiography (CA) revealed a radiological pattern of multifocal FMD. The angiography of the aorta and its branches showed adiffuse dysplasia of the renal arteries. The patient was put under antiaggregants. The modified Rankin score (mRS) after three months was three. Conclusion: Cerebrovascular FMD has typical angiographic features, the “string of beads” appearance being the most common. Although the risk of a stroke in patients with cervical FMD is low, it can lead to a severe stroke and the long-term risks are unknown. Patient registries should be encouraged to better understand the mechanisms and evolutionary profile of FMD and alert clinicians to this potentially disabling condition.展开更多
In recent years,Chinese oil companies have been pacing the globe to secure energy assets to fuel the fast-growing Asian powerhouse's economy.China's enterprises eyed global expansion via mergers and acquisitio...In recent years,Chinese oil companies have been pacing the globe to secure energy assets to fuel the fast-growing Asian powerhouse's economy.China's enterprises eyed global expansion via mergers and acquisitions(M&A)in 2010 as展开更多
Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate br...Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate bronchial ast hma.Methods: Sixty patients were divided randomly into the treated gr oup and the control group, 30 in each group. They were treated with XYA and Salb utamol aerosol (SA) respectively by spray inhalation once a day for seven days a s one therapeutic course to observe the antiasthmatic effect of the treatment. Changes of lung function and the levels of tumor necrosis factor α (TNF-α) , interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunos orbent assay (ELISA). Levels of TNF-α, IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed.Results: In the treated group, 6 patients had the asthma clinica lly controlled after treatment, 12 were markedly alleviated, 9 alleviated and 3 remained unchanged, while in the control group, the respective numbers were 4, 6 , 15 and 5. The controlled-markedly effective rate of XYA was 60.0%, which wa s significantly better than that of SA (33.3%, P <0.05). The one second forc ed expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improv ed significantly and the levels of TNF-α, IL-2R and IL-8 in serum decr eased noticeably in both groups after treatment ( P <0.05 or P <0.01), but the improvement in the treated group was more significant as compared with tho se in the control group ( P <0.05). The levels of TNF-α, IL-2R and IL -8 in sputum considerably lowered also after XYA treatment ( P <0.01).Conclusion: XYA could regulate the related cytokines in patient s with mild or moderate bronchial asthma, and reduce the releasing of inflammato ry factors, which is consistent with the improvement of lung functions, so as to ease the airway inflammation chiefly exhibited as cell infiltration in bron chi.展开更多
文摘Background: Fibromuscular dysplasia (FMD) is a rare idiopathic segmental non-arteriosclerotic and non-inflammatory arterial disease of small to medium-sized vessels. Although it is considered a benign entity, FMD can lead to potentially severe cerebrovascular complications. We present an atypical clinical case of ischemic stroke (IS) caused by bilateral carotid dissection revealing multifocal FMD. Case Report: A 43-year-old right-handed female with no medical history suddenly developed somnolence with left-sided weakness. Clinical examination revealed left hemiplegia and left central facial paralysis with an NIHSS score: 22. Cerebral tomography (CT) with arterial angiogram revealed abilateralis of the middle cerebral arteries (MCA), a double dissection of the internal carotids (IC), aneurysmal ectasia of the left IC, and aneurysm of the M2 segment of the MCA. Brain magnetic resonance imaging (MRI) with arterial angiography confirmed the bilateral dissection. A cerebral angiography (CA) revealed a radiological pattern of multifocal FMD. The angiography of the aorta and its branches showed adiffuse dysplasia of the renal arteries. The patient was put under antiaggregants. The modified Rankin score (mRS) after three months was three. Conclusion: Cerebrovascular FMD has typical angiographic features, the “string of beads” appearance being the most common. Although the risk of a stroke in patients with cervical FMD is low, it can lead to a severe stroke and the long-term risks are unknown. Patient registries should be encouraged to better understand the mechanisms and evolutionary profile of FMD and alert clinicians to this potentially disabling condition.
文摘In recent years,Chinese oil companies have been pacing the globe to secure energy assets to fuel the fast-growing Asian powerhouse's economy.China's enterprises eyed global expansion via mergers and acquisitions(M&A)in 2010 as
文摘Objective: To observe the therapeutic effect of composite Xinyi ae rosol (复方辛夷雾化剂, XYA) in treating asthma and its influence on asthma relat ed cytokines in serum and sputum of patients with mild or moderate bronchial ast hma.Methods: Sixty patients were divided randomly into the treated gr oup and the control group, 30 in each group. They were treated with XYA and Salb utamol aerosol (SA) respectively by spray inhalation once a day for seven days a s one therapeutic course to observe the antiasthmatic effect of the treatment. Changes of lung function and the levels of tumor necrosis factor α (TNF-α) , interleukine-2 receptor (IL-2R) and interleukine-8 (IL-8) in serum and sputum were observed before and after treatment using enzyme linked immunos orbent assay (ELISA). Levels of TNF-α, IL-2R andIL-8 in the sputum of part of the patients in the treatment group were also observed.Results: In the treated group, 6 patients had the asthma clinica lly controlled after treatment, 12 were markedly alleviated, 9 alleviated and 3 remained unchanged, while in the control group, the respective numbers were 4, 6 , 15 and 5. The controlled-markedly effective rate of XYA was 60.0%, which wa s significantly better than that of SA (33.3%, P <0.05). The one second forc ed expiratory volume percent (FEV1%) and peek expiratory flow rate (PEFR) improv ed significantly and the levels of TNF-α, IL-2R and IL-8 in serum decr eased noticeably in both groups after treatment ( P <0.05 or P <0.01), but the improvement in the treated group was more significant as compared with tho se in the control group ( P <0.05). The levels of TNF-α, IL-2R and IL -8 in sputum considerably lowered also after XYA treatment ( P <0.01).Conclusion: XYA could regulate the related cytokines in patient s with mild or moderate bronchial asthma, and reduce the releasing of inflammato ry factors, which is consistent with the improvement of lung functions, so as to ease the airway inflammation chiefly exhibited as cell infiltration in bron chi.
