Polymer acceptors based on extended fused ring p skeleton has been proven to be promising candidates for all-polymer solar cells(all-PSCs), due to their remarkable improved light absorption than the traditional imide-...Polymer acceptors based on extended fused ring p skeleton has been proven to be promising candidates for all-polymer solar cells(all-PSCs), due to their remarkable improved light absorption than the traditional imide-based polymer acceptors. To expand structural diversity of the polymer acceptors, herein,two polymer acceptors PSF-IDIC and PSi-IDIC with extended fused ring p skeleton are developed by copolymerization of 2,20-((2 Z,20 Z)-((4,4,9,9-tetrahexadecyl-4,9-dihydro-s-indaceno [1,2-b:5,6-b']dithio phene-2,7-diyl)bis(methanylylidene))bis(3-oxo-2,3-dihydro-1 H-indene-2,1-diylidene))dimalononitrile(IDIC-C16) block with sulfur(S) and fluorine(F) functionalized benzodithiophene(BDT) unit and silicon(Si) atom functionalized BDT unit, respectively. Both polymer acceptors exhibit strong light absorption.The PSF-IDIC exhibits similar energy levels and slightly higher absorption coefficient relative to the PSi-IDIC. After blended with the donor polymer PM6, the functional atoms on the polymer acceptors show quite different effect on the device performance. Both of the acceptors deliver a notably high open circuit voltage(V_(OC)) of the devices, but PSi-IDIC achieves higher V OCthan PSF-IDIC. All-PSC based on PM6:PSi-IDIC attains a power conversion efficiency(PCE) of 8.29%, while PM6:PSF-IDIC-based device achieves a much higher PCE of 10.18%, which is one of the highest values for the all-PSCs reported so far. The superior device performance of PM6:PSF-IDIC is attributed to its higher exciton dissociation and charge transport, decreased charge recombination, and optimized morphology than PM6:PSi-IDIC counterpart. These results suggest that optimizing the functional atoms of the side chain provide an effective strategy to develop high performance polymer acceptors for all-PSCs.展开更多
In this article,three novel and simple molecular structure with donor-acceptor(D-A) type copolymers via only head-to-head alkoxy(OR) and/or alkylthio(SR) side chains onto the bithiophene(BT) as donor units and fluorin...In this article,three novel and simple molecular structure with donor-acceptor(D-A) type copolymers via only head-to-head alkoxy(OR) and/or alkylthio(SR) side chains onto the bithiophene(BT) as donor units and fluorinated benzotriazole(FBTA) as acceptor unit,namely,PBTOR-FBTA,PBTOSR-FBTA and PBTSRFBTA,were successfully designed and synthesized.The impacts of sulfur-oxygen(S…O) or sulfur-sulfur(S-S) noncovalent interactions on their physicochemical properties,molecular stacking,carrier mobility,morphologies of blend films,as well as their photovoltaic performance were deeply and systematically studied.The introduction of SR side-chains suddenly lowered the highest occupied molecular orbital(HOMO) energy levels,blue-shifted absorption,enhanced π-π stacking,as well as improved morphology of the photoactive layer blends in comparison with the re ference polymer without SR side-chain.Polymer solar cells(PSCs) were fabricated to estimate their photovoltaic performance of the polymers.Under an optimized blend ratio of PBTSR-FBTA:PC71BM(1:0.8,w/w),the PBTSR-FBTAbased device exhibits a higher power conversion efficiency(PCE) of 6.25%,which is about 3.34 and 1.87 folds than that of the PBTOR-FBTA and PBTOSR-FBTA-based devices,respectively.Our research results demonstrate that the modification of the simple and low-cost SR side chains is an effective strategy to improve the photovoltaic performance of the polymers.展开更多
Lysosomal iron overload,resulting from dysregulated ferritinophagy,is a significant early event in the progression of Parkinson’s disease(PD).This condition causes iron accumulation within cells,triggering oxidative ...Lysosomal iron overload,resulting from dysregulated ferritinophagy,is a significant early event in the progression of Parkinson’s disease(PD).This condition causes iron accumulation within cells,triggering oxidative stress and ferroptosis,along with mitochondrial dysfunction andα-synuclein(α-syn)aggregation,ultimately damaging dopaminergic neurons irreversibly.However,tools for real-time monitoring of Fe^(3+) dynamics in vivo are limited.In this study,we introduce TPE-4B/4Q[7],a supramolecular fluorescent probe designed for selective and stable tracking of Fe^(3+) changes within lysosomes.This probe exhibits excellent photostability,low cytotoxicity,and a detection limit of 1.23×10^(−6) M.In cellular models of PD,TPE-4B/4Q[7]effectively monitors lysosomal ferritinophagy-induced Fe^(3+) overload,allowing for the assessment of oxidative stress,mitochondrial function,and the levels of key biomarkers such asα-syn and tyrosine hydroxylase.Additionally,this probe can track iron accumulation linked to neurodegenerative lesions in Caenorhabditis elegans and MPTP-induced PD mouse models,with signal changes correlating closely with neurodegenerative phenotypes and molecular pathology.Notably,TPE-4B/4Q[7]enables non-invasive brain imaging via nasal delivery.TPE-4B/4Q[7]is a sensitive molecular indicator for early risk assessment and monitoring of PD progression.It is anticipated to be an effective instrument for the early diagnosis of PD.展开更多
基金the National Natural Science Foundation of China (NSFC) (51673092, 51973087 and 21762029) for financial support。
文摘Polymer acceptors based on extended fused ring p skeleton has been proven to be promising candidates for all-polymer solar cells(all-PSCs), due to their remarkable improved light absorption than the traditional imide-based polymer acceptors. To expand structural diversity of the polymer acceptors, herein,two polymer acceptors PSF-IDIC and PSi-IDIC with extended fused ring p skeleton are developed by copolymerization of 2,20-((2 Z,20 Z)-((4,4,9,9-tetrahexadecyl-4,9-dihydro-s-indaceno [1,2-b:5,6-b']dithio phene-2,7-diyl)bis(methanylylidene))bis(3-oxo-2,3-dihydro-1 H-indene-2,1-diylidene))dimalononitrile(IDIC-C16) block with sulfur(S) and fluorine(F) functionalized benzodithiophene(BDT) unit and silicon(Si) atom functionalized BDT unit, respectively. Both polymer acceptors exhibit strong light absorption.The PSF-IDIC exhibits similar energy levels and slightly higher absorption coefficient relative to the PSi-IDIC. After blended with the donor polymer PM6, the functional atoms on the polymer acceptors show quite different effect on the device performance. Both of the acceptors deliver a notably high open circuit voltage(V_(OC)) of the devices, but PSi-IDIC achieves higher V OCthan PSF-IDIC. All-PSC based on PM6:PSi-IDIC attains a power conversion efficiency(PCE) of 8.29%, while PM6:PSF-IDIC-based device achieves a much higher PCE of 10.18%, which is one of the highest values for the all-PSCs reported so far. The superior device performance of PM6:PSF-IDIC is attributed to its higher exciton dissociation and charge transport, decreased charge recombination, and optimized morphology than PM6:PSi-IDIC counterpart. These results suggest that optimizing the functional atoms of the side chain provide an effective strategy to develop high performance polymer acceptors for all-PSCs.
基金financially supported by grants from the National Natural Science Foundation of China(Nos.51573154,51673031)The Natural Science Foundation of Jiangsu Higher Institutions of China(No.18KJA480001)+2 种基金the Youth Science and Technology Foundation of Sichuan Province(No.2013JQ0032)the key Laboratory of Environment-Friendly Chemistry and Applications of Ministry of Education(No.2018HJYH01)the Natural Science Foundation of Jiangsu Province(No.BK20141151)。
文摘In this article,three novel and simple molecular structure with donor-acceptor(D-A) type copolymers via only head-to-head alkoxy(OR) and/or alkylthio(SR) side chains onto the bithiophene(BT) as donor units and fluorinated benzotriazole(FBTA) as acceptor unit,namely,PBTOR-FBTA,PBTOSR-FBTA and PBTSRFBTA,were successfully designed and synthesized.The impacts of sulfur-oxygen(S…O) or sulfur-sulfur(S-S) noncovalent interactions on their physicochemical properties,molecular stacking,carrier mobility,morphologies of blend films,as well as their photovoltaic performance were deeply and systematically studied.The introduction of SR side-chains suddenly lowered the highest occupied molecular orbital(HOMO) energy levels,blue-shifted absorption,enhanced π-π stacking,as well as improved morphology of the photoactive layer blends in comparison with the re ference polymer without SR side-chain.Polymer solar cells(PSCs) were fabricated to estimate their photovoltaic performance of the polymers.Under an optimized blend ratio of PBTSR-FBTA:PC71BM(1:0.8,w/w),the PBTSR-FBTAbased device exhibits a higher power conversion efficiency(PCE) of 6.25%,which is about 3.34 and 1.87 folds than that of the PBTOR-FBTA and PBTOSR-FBTA-based devices,respectively.Our research results demonstrate that the modification of the simple and low-cost SR side chains is an effective strategy to improve the photovoltaic performance of the polymers.
基金supported by the National Natural Science Foundation of China(21865006)Key Project of Basic Research Program of Guizhou Province,China(No.ZK[2021]022)+2 种基金Youth Guidance Project of Basic Research Program of Guizhou Province,China(No.[2024]231)Training Project of the National Natural Science Foundation of Guizhou Medical University,China(Nos.21NSFCP33 and 22NSFCP06)the Guizhou Provincial Training Programs of Innovation and Entrepreneurship for Undergraduates,China(S202310660093).
文摘Lysosomal iron overload,resulting from dysregulated ferritinophagy,is a significant early event in the progression of Parkinson’s disease(PD).This condition causes iron accumulation within cells,triggering oxidative stress and ferroptosis,along with mitochondrial dysfunction andα-synuclein(α-syn)aggregation,ultimately damaging dopaminergic neurons irreversibly.However,tools for real-time monitoring of Fe^(3+) dynamics in vivo are limited.In this study,we introduce TPE-4B/4Q[7],a supramolecular fluorescent probe designed for selective and stable tracking of Fe^(3+) changes within lysosomes.This probe exhibits excellent photostability,low cytotoxicity,and a detection limit of 1.23×10^(−6) M.In cellular models of PD,TPE-4B/4Q[7]effectively monitors lysosomal ferritinophagy-induced Fe^(3+) overload,allowing for the assessment of oxidative stress,mitochondrial function,and the levels of key biomarkers such asα-syn and tyrosine hydroxylase.Additionally,this probe can track iron accumulation linked to neurodegenerative lesions in Caenorhabditis elegans and MPTP-induced PD mouse models,with signal changes correlating closely with neurodegenerative phenotypes and molecular pathology.Notably,TPE-4B/4Q[7]enables non-invasive brain imaging via nasal delivery.TPE-4B/4Q[7]is a sensitive molecular indicator for early risk assessment and monitoring of PD progression.It is anticipated to be an effective instrument for the early diagnosis of PD.
