The influences of some factors on the yield of phenylacetic acid in thecarbonylation of benzyl chloride were studied in this paper. These factors included the variety andcontent of catalyst, and that of solvent, way o...The influences of some factors on the yield of phenylacetic acid in thecarbonylation of benzyl chloride were studied in this paper. These factors included the variety andcontent of catalyst, and that of solvent, way of material feeding, reaction temperature, sodiumhydrate concentration, triphenylphosphine content, presence of surfactant, the ratio of organicphase volume to aqueous phase volume etc. The optimum reaction conditions were found to be: with aone-time pour of 0.15 g Pd(PPh_3)_2Cl_2, 0.24 g PPh_3, 75 ml NaOH of 3.5 mol/L, 20 ml benzylchloride and 55 ml n-butyl alcohol, and the reaction was carried out at 50℃ for about 3 hours. Theas-obtained yield of phenylacetic acid was as high as 97.6%. In addition, the influences of thepresence of phenylacetic acid and air in the reaction system were also studied. The results showedthat the presence of air in the system and the entrainment of phenylacetic acid in the circulatingorganic phase had great influence on the reaction rate, the stability and performance of catalystand the yield of phenylacetic acid.展开更多
基金Project supported by the foundation of Scientific and Technological from the Ministry of Education (03071), of Natural Science Foundation of Jiangxi Province (0320013) and of the Youth Foundation of Nanchang University.
文摘The influences of some factors on the yield of phenylacetic acid in thecarbonylation of benzyl chloride were studied in this paper. These factors included the variety andcontent of catalyst, and that of solvent, way of material feeding, reaction temperature, sodiumhydrate concentration, triphenylphosphine content, presence of surfactant, the ratio of organicphase volume to aqueous phase volume etc. The optimum reaction conditions were found to be: with aone-time pour of 0.15 g Pd(PPh_3)_2Cl_2, 0.24 g PPh_3, 75 ml NaOH of 3.5 mol/L, 20 ml benzylchloride and 55 ml n-butyl alcohol, and the reaction was carried out at 50℃ for about 3 hours. Theas-obtained yield of phenylacetic acid was as high as 97.6%. In addition, the influences of thepresence of phenylacetic acid and air in the reaction system were also studied. The results showedthat the presence of air in the system and the entrainment of phenylacetic acid in the circulatingorganic phase had great influence on the reaction rate, the stability and performance of catalystand the yield of phenylacetic acid.
