The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills(CDDP)in improving cardiac function in patients with acute anterior ST-segment elevation myocardial infarction(AAMI).Betwee...The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills(CDDP)in improving cardiac function in patients with acute anterior ST-segment elevation myocardial infarction(AAMI).Between February 2021 and February 2023,247 eligible patients with AAMI after primary percutaneous coronary intervention were enrolled and randomly assigned(1∶1)to receive CDDP(n=126)or placebo(n=121),with a follow-up of 48 weeks.Compared with the placebo group,the CDDP group demonstrated a significant increase in left ventricular ejection fraction values after 24 weeks of treatment(least squares mean:3.31;95%confidence interval[CI]:1.72–4.90;P<0.001)and at the 48-week follow-up(least squares mean:4.35;95%CI:2.76–5.94;P<0.001).Significant reductions in N-terminal pro-B-type natriuretic peptide levels were observed in both groups at the 24-and 48-week visits with no significant difference between the two groups(P>0.1 for all).The incidence of major adverse cardiovascular and cerebrovascular events was 6.35%in the CDDP group and 5.79%in the placebo group(P=0.822).Notably,no serious adverse events were attributed to CDDP.These findings suggest that CDDP may be well tolerated and could improve left ventricular ejection fraction in patients with AAMI at 24 and 48 weeks.展开更多
This paper proposes a new constructive texture synthesis steganographic scheme by compressing original secret messages.First,we divide the original message into multiple bit blocks,which are transferred to decimal val...This paper proposes a new constructive texture synthesis steganographic scheme by compressing original secret messages.First,we divide the original message into multiple bit blocks,which are transferred to decimal values and compressed into small decimal values by recording their interval sign characters.Then,a candidate pattern is generated by combining the given source pattern and boundary extension algorithm.Furthermore,we segment the candidate pattern into multiple candidate patches and use affine transformation algorithm to locate secret positions on a blank canvas,which are used to hide the sign characters by mapping the candidate patches.Finally,we select the candidate patches with minimal mean square error to represent secret bits to generate stego image by image quilting.Extensive experiments demonstrate that compared with existing texture steganographic methods,our method has a better visual quality,higher embedding capacity and security performance,while maintaining strong anti-steganalysis capability.展开更多
基金supported by Tasly Pharmaceutical Group Co.,Ltd.(Grant No.303100031BA20)。
文摘The current study aimed to evaluate the efficacy and safety of Compound Danshen Dripping Pills(CDDP)in improving cardiac function in patients with acute anterior ST-segment elevation myocardial infarction(AAMI).Between February 2021 and February 2023,247 eligible patients with AAMI after primary percutaneous coronary intervention were enrolled and randomly assigned(1∶1)to receive CDDP(n=126)or placebo(n=121),with a follow-up of 48 weeks.Compared with the placebo group,the CDDP group demonstrated a significant increase in left ventricular ejection fraction values after 24 weeks of treatment(least squares mean:3.31;95%confidence interval[CI]:1.72–4.90;P<0.001)and at the 48-week follow-up(least squares mean:4.35;95%CI:2.76–5.94;P<0.001).Significant reductions in N-terminal pro-B-type natriuretic peptide levels were observed in both groups at the 24-and 48-week visits with no significant difference between the two groups(P>0.1 for all).The incidence of major adverse cardiovascular and cerebrovascular events was 6.35%in the CDDP group and 5.79%in the placebo group(P=0.822).Notably,no serious adverse events were attributed to CDDP.These findings suggest that CDDP may be well tolerated and could improve left ventricular ejection fraction in patients with AAMI at 24 and 48 weeks.
基金supported by Natural Science Foundation of China under Grants(U1736120,61602295).
文摘This paper proposes a new constructive texture synthesis steganographic scheme by compressing original secret messages.First,we divide the original message into multiple bit blocks,which are transferred to decimal values and compressed into small decimal values by recording their interval sign characters.Then,a candidate pattern is generated by combining the given source pattern and boundary extension algorithm.Furthermore,we segment the candidate pattern into multiple candidate patches and use affine transformation algorithm to locate secret positions on a blank canvas,which are used to hide the sign characters by mapping the candidate patches.Finally,we select the candidate patches with minimal mean square error to represent secret bits to generate stego image by image quilting.Extensive experiments demonstrate that compared with existing texture steganographic methods,our method has a better visual quality,higher embedding capacity and security performance,while maintaining strong anti-steganalysis capability.
