Ferroptosis is an iron-dependent,excessive lipid peroxidation-driven form of regulated cell death.The core mechanisms of ferroptosis include lipid peroxidation cascade,System X_(c)^(−)-glutathioneglutathione peroxidas...Ferroptosis is an iron-dependent,excessive lipid peroxidation-driven form of regulated cell death.The core mechanisms of ferroptosis include lipid peroxidation cascade,System X_(c)^(−)-glutathioneglutathione peroxidase 4 axis,iron and lipid metabolism chaos,the NAD(P)Hferroptosis suppressor protein 1—ubiquinone axis,and GTP cyclohydrolase 1 tetrahydrobiopterin-dihydrofolate reductase axis.Cuproptosis is triggered by copper ions and involves ferredoxin 1-mediated aggregation of lipoylated proteins,differing fundamentally from ferroptosis.Both ferroptosis and cuproptosis exhibit dual roles(promote or inhibit)in cancers.And the sensitivity of different cancer types to ferroptosis varies,which may depend on special metabolic signatures(e.g.,E-cadherin loss causes epithelial–mesenchymal transition,making tumors gain resistance to ferroptosis)and expression of antioxidant defense regulators(e.g.,high expression of Acyl-CoA synthetase long-chain family member 4 and lncFASA make tumors easily sensitive).At present,traditional Chinese herbal medicine,combination therapy,and nano-delivery technology correlated with ferroptosis are being hotly studied by researchers in order to realize clinical translation of ferroptosis.In this review,we have summarized the core mechanisms of ferroptosis,ferroptosis differences from cuproptosis,its impact on cancers,and its translational implications in cancer therapy,helping readers quickly get the new information and horizons on them.展开更多
Original reference:iEnergy,2(2):93-99,2023 Droplet-based triboelectric nanogenerator(D-TENG)using liquid-solid contact electrification has been widely studied for harvesting raindrop energy and ocean energy due to its...Original reference:iEnergy,2(2):93-99,2023 Droplet-based triboelectric nanogenerator(D-TENG)using liquid-solid contact electrification has been widely studied for harvesting raindrop energy and ocean energy due to its unique ability to effectively reduce friction between solids and improve durability.In 2020,a new-generation D-TENG with a“transistor-like”struc-ture was proposed,which first achieved ultra-high instantaneous power output(50 W/m2).Subsequently,D-TENG has been rapidly developed and is widely used in ocean wave energy power gener-ation and liquid-solid triboelectric power generation.Currently,although we have excellent D-TENGs to harvest energy from a single water droplet,but if multiple D-TENGs are simply connected in parallel for a large area usage,the output power of the whole power generation module will drop significantly due to the mutual influence between different individual generation units,which severely limits their applications in practice.Therefore,finding a reasonable topology to relieve the inherent constraints of D-TENGs is of great significance for realizing the large-scale rain-drop energy harvesting.展开更多
Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hya...Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hyaluronic acid methacryloyl(HAMA)and encapsulating Mg^(2+),are promising options for meniscal repair.However,the inflammatory response following implantation is a significant concern.In this study,we prepared a composite SF/HAMA-Mg hydrogel scaffold,evaluated its physical and chemical properties,and detected its fibrochondrogenic differentiation effect in vitro and the healing effect in a rabbit meniscus defect model in vivo.Our results showed that the scaffold differentiates pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages after implantation,thereby reducing inflammation and facilitating the growth and repair of meniscus tissue.Further,the composite scaffold provided a conducive milieu for cell proliferation,anticipatory differentiation,and generation of extracellular matrix.In summary,composite SF/HAMA-Mg scaffolds exhibit exceptional biocompatibility and anti-inflammatory properties,demonstrating superior potential for meniscal repair.展开更多
基金supported by National Natural Science Foundation(82272695)the Key Program of Natural Science Foundation of Zhejiang Province(LZ23H160004)National Undergraduate Training Program for Innovation and Entrepreneurship,Zhejiang Xinmiao Talents Program,China.
文摘Ferroptosis is an iron-dependent,excessive lipid peroxidation-driven form of regulated cell death.The core mechanisms of ferroptosis include lipid peroxidation cascade,System X_(c)^(−)-glutathioneglutathione peroxidase 4 axis,iron and lipid metabolism chaos,the NAD(P)Hferroptosis suppressor protein 1—ubiquinone axis,and GTP cyclohydrolase 1 tetrahydrobiopterin-dihydrofolate reductase axis.Cuproptosis is triggered by copper ions and involves ferredoxin 1-mediated aggregation of lipoylated proteins,differing fundamentally from ferroptosis.Both ferroptosis and cuproptosis exhibit dual roles(promote or inhibit)in cancers.And the sensitivity of different cancer types to ferroptosis varies,which may depend on special metabolic signatures(e.g.,E-cadherin loss causes epithelial–mesenchymal transition,making tumors gain resistance to ferroptosis)and expression of antioxidant defense regulators(e.g.,high expression of Acyl-CoA synthetase long-chain family member 4 and lncFASA make tumors easily sensitive).At present,traditional Chinese herbal medicine,combination therapy,and nano-delivery technology correlated with ferroptosis are being hotly studied by researchers in order to realize clinical translation of ferroptosis.In this review,we have summarized the core mechanisms of ferroptosis,ferroptosis differences from cuproptosis,its impact on cancers,and its translational implications in cancer therapy,helping readers quickly get the new information and horizons on them.
文摘Original reference:iEnergy,2(2):93-99,2023 Droplet-based triboelectric nanogenerator(D-TENG)using liquid-solid contact electrification has been widely studied for harvesting raindrop energy and ocean energy due to its unique ability to effectively reduce friction between solids and improve durability.In 2020,a new-generation D-TENG with a“transistor-like”struc-ture was proposed,which first achieved ultra-high instantaneous power output(50 W/m2).Subsequently,D-TENG has been rapidly developed and is widely used in ocean wave energy power gener-ation and liquid-solid triboelectric power generation.Currently,although we have excellent D-TENGs to harvest energy from a single water droplet,but if multiple D-TENGs are simply connected in parallel for a large area usage,the output power of the whole power generation module will drop significantly due to the mutual influence between different individual generation units,which severely limits their applications in practice.Therefore,finding a reasonable topology to relieve the inherent constraints of D-TENGs is of great significance for realizing the large-scale rain-drop energy harvesting.
基金supported by grants from the Beijing Natural Science Foundation,China(No.7244431)the Postdoctoral Science Foundation of China(No.2022M710260)the National Natural Science Foundation of China(No.82202723).
文摘Meniscal injury,a prevalent and challenging medical condition,is characterized by poor self-healing potential and a complex microenvironment.Tissue engineering scaffolds,particularly those made of silk fibroin(SF)/hyaluronic acid methacryloyl(HAMA)and encapsulating Mg^(2+),are promising options for meniscal repair.However,the inflammatory response following implantation is a significant concern.In this study,we prepared a composite SF/HAMA-Mg hydrogel scaffold,evaluated its physical and chemical properties,and detected its fibrochondrogenic differentiation effect in vitro and the healing effect in a rabbit meniscus defect model in vivo.Our results showed that the scaffold differentiates pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages after implantation,thereby reducing inflammation and facilitating the growth and repair of meniscus tissue.Further,the composite scaffold provided a conducive milieu for cell proliferation,anticipatory differentiation,and generation of extracellular matrix.In summary,composite SF/HAMA-Mg scaffolds exhibit exceptional biocompatibility and anti-inflammatory properties,demonstrating superior potential for meniscal repair.
