We have entered an era of rapid advances in neuroscience.The integration of innovative imaging technology,validated behavioral measures,and state-of-the-art algorithms is gradually unraveling the fundamental rules tha...We have entered an era of rapid advances in neuroscience.The integration of innovative imaging technology,validated behavioral measures,and state-of-the-art algorithms is gradually unraveling the fundamental rules that link the nervous system and complex behaviors,subsequently guiding diagnostics and therapeutics.However,there is a long history of an explicit lack of population diversity in neuroscience research.Although most influential studies in our field aim to elucidate universal and objective truths,it is disconcerting that the Western,educated,industrialized,rich,and democratic(WEIRD)populations are overrepresented[1].展开更多
Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Method...Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Methods:Resting-state functional magnetic resonance imaging(rs-fMRI)data were collected from 20 patients with PD and 20 normal controls(NC).Each patient with PD received successivemultidisciplinary intensive rehabilitation treatment and tACStreatment over a one-year interval.Individual functional brain network mapping and co-activation pattern(CAP)analysis were performed to characterize cortico–subcortical dynamics.Results:The same tACS electrode placement stimulated different proportions of functional brain networks across the participants.CAP analysis revealed that the visual network,attentional network,and default mode network co-activated with the thalamus,accumbens,and amygdala,respectively.The pattern characterized by thede-activation of the visual network and the activation of the thalamus showed a significantly low amplitude in the patients with PD than inNCs,and this amplitude increased after tACS treatment.Furthermore,the co-occurrence of cortico–subcortical CAPs was significantly higherin patients with PD than in NCs and decreased after tACS treatment.Conclusions:This study investigated cortico–subcortical spatiotemporaldynamics in patients with PD and further revealed the tACS treatmentmechanism.These findings contribute to understanding cortico–subcortical dynamics and exploring noninvasive neuromodulationtargets of cortico–subcortical circuits in brain diseases,such as PD,Alzheimer’s disease,and depression.展开更多
基金supported by the National Natural Science Foundation of China(62336002 and 82302175)the National Science and Technology Innovation 2030 Program(2021ZD0200500)Xi-Nian Zuo is supported by the Start-up Funds for Leading Talents at Beijing Normal University.
文摘We have entered an era of rapid advances in neuroscience.The integration of innovative imaging technology,validated behavioral measures,and state-of-the-art algorithms is gradually unraveling the fundamental rules that link the nervous system and complex behaviors,subsequently guiding diagnostics and therapeutics.However,there is a long history of an explicit lack of population diversity in neuroscience research.Although most influential studies in our field aim to elucidate universal and objective truths,it is disconcerting that the Western,educated,industrialized,rich,and democratic(WEIRD)populations are overrepresented[1].
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.U20A20191,82071912,12104049,82202291)the Fundamental Research Funds for the Central Universities(Grant No.2021CX11011)the National Key Research and Development Program of China(Grant No.2020YFC2007305).
文摘Objective:We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms oftranscranial alternating current stimulation(tACS)in patientswith Parkinson’s disease(PD).Methods:Resting-state functional magnetic resonance imaging(rs-fMRI)data were collected from 20 patients with PD and 20 normal controls(NC).Each patient with PD received successivemultidisciplinary intensive rehabilitation treatment and tACStreatment over a one-year interval.Individual functional brain network mapping and co-activation pattern(CAP)analysis were performed to characterize cortico–subcortical dynamics.Results:The same tACS electrode placement stimulated different proportions of functional brain networks across the participants.CAP analysis revealed that the visual network,attentional network,and default mode network co-activated with the thalamus,accumbens,and amygdala,respectively.The pattern characterized by thede-activation of the visual network and the activation of the thalamus showed a significantly low amplitude in the patients with PD than inNCs,and this amplitude increased after tACS treatment.Furthermore,the co-occurrence of cortico–subcortical CAPs was significantly higherin patients with PD than in NCs and decreased after tACS treatment.Conclusions:This study investigated cortico–subcortical spatiotemporaldynamics in patients with PD and further revealed the tACS treatmentmechanism.These findings contribute to understanding cortico–subcortical dynamics and exploring noninvasive neuromodulationtargets of cortico–subcortical circuits in brain diseases,such as PD,Alzheimer’s disease,and depression.
