Background and Objectives:Obese and diabetic individuals tend to have insulin resistance,but are less likely to develop osteoporosis.The association of triglyceride-glucose(TyG)related indices with osteoporosis remain...Background and Objectives:Obese and diabetic individuals tend to have insulin resistance,but are less likely to develop osteoporosis.The association of triglyceride-glucose(TyG)related indices with osteoporosis remains controversial,and longitudinal evidence exploring the male osteoporosis(MOP)is limited.This study aims to examine TyG,TyG-body mass index(TyG-BMI)and the metabolic score for insulin resistance(METS-IR)with osteoporosis risk among older men.Methods and Study Design:A cohort study based on 1622 middle-aged and older men in 2015 was conducted,and followed up until 2022.Participants with osteoporosis and admittedly secondary risk factors were excluded.TyG,TyG-BMI,METS-IR and corresponding quantiles were calculated.Cox proportional hazard regression models were used to assess the hazard ratios(HRs)and 95%confidence interval(CI).Receiver operating characteristic(ROC)curve was applied to estimate their performance in osteoporosis screening.Results:72 of 1622 participants were newly developed OP during the 9317 person-years.The adjusted HRs of TyG,TyG-BMI,and METS-IR for MOP were 0.573(95%CI 0.336-0.976),0.991(95%CI 0.984-0.999)and 0.929(95%CI 0.892-0.968),respectively,and presented at linear dose-response relationships.Subgroup analysis showed that the estimated benefit for MOP incidence was consistent among participants aged more than 70 years and related to BMI and eating mount of milk,fresh fruit and vegetables.No difference was found in the area under ROC curve for screening osteoporosis,ranging from 0.585 to 0.617.Conclusions:TyG and relevant indices were associated with the incidence of osteoporosis in the senile men,and the relationship was thought to correlate with BMI and nutritional behaviors.展开更多
Background and Objectives:Malnutrition is associated with a higher risk of osteoporosis.We aim to assess the relationship between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly m...Background and Objectives:Malnutrition is associated with a higher risk of osteoporosis.We aim to assess the relationship between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly men.Methods and S tudy Design:This is a nested case-control study from a prospective cohort enrolled 1109 indi viduals who were followed for seven years.Demographic data,medical history,signs and symptoms,and labora tory parameters were collected and analysed.Nutritional status and Geriatric Nutritional Risk Index(GNRI)were assessed.The nutrition-related indexes predictive value for osteopenia development was analyzed through multi variate Cox regression analysis and by creating a receiver operating characteristic curve(ROC),calculating the area under the curve(AUC).Kaplan-Meier(K-M)method was further used to find the nutritional status level in the elderly men.Results:The ALB and GNRI correlated with the risk of osteopenia in Chinese elderly men.Af ter adjusting for all covariates,people with higher ALB level(HR:0.821;95%CI:0.790-0.852)and higher GNRI score(HR:0.889;95%CI:0.869-0.908)had a smaller risk of o steopenia.ROC analysis showed that the AUC for ALB was 0.729(p˂0.05)and for the GNRI score was 0.731(p˂0.05).K-M curve indicated a significant difference in ALB level(p˂0.001)and GNRI score(p˂0.001)in the respective subgroups.Conclusions:This study found that lower ALB level and lower GNRI score are associat ed with a higher prevalence of osteopenia among elderly men in China.展开更多
基金Multi-center RCT Clinical Project of the National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Grant/Award Number:NCRCG-PLAGH-2023001Beijing Nova program,Grant/Award Number:20220484020.
文摘Background and Objectives:Obese and diabetic individuals tend to have insulin resistance,but are less likely to develop osteoporosis.The association of triglyceride-glucose(TyG)related indices with osteoporosis remains controversial,and longitudinal evidence exploring the male osteoporosis(MOP)is limited.This study aims to examine TyG,TyG-body mass index(TyG-BMI)and the metabolic score for insulin resistance(METS-IR)with osteoporosis risk among older men.Methods and Study Design:A cohort study based on 1622 middle-aged and older men in 2015 was conducted,and followed up until 2022.Participants with osteoporosis and admittedly secondary risk factors were excluded.TyG,TyG-BMI,METS-IR and corresponding quantiles were calculated.Cox proportional hazard regression models were used to assess the hazard ratios(HRs)and 95%confidence interval(CI).Receiver operating characteristic(ROC)curve was applied to estimate their performance in osteoporosis screening.Results:72 of 1622 participants were newly developed OP during the 9317 person-years.The adjusted HRs of TyG,TyG-BMI,and METS-IR for MOP were 0.573(95%CI 0.336-0.976),0.991(95%CI 0.984-0.999)and 0.929(95%CI 0.892-0.968),respectively,and presented at linear dose-response relationships.Subgroup analysis showed that the estimated benefit for MOP incidence was consistent among participants aged more than 70 years and related to BMI and eating mount of milk,fresh fruit and vegetables.No difference was found in the area under ROC curve for screening osteoporosis,ranging from 0.585 to 0.617.Conclusions:TyG and relevant indices were associated with the incidence of osteoporosis in the senile men,and the relationship was thought to correlate with BMI and nutritional behaviors.
基金National Key Research and Development Program of Chi na(No.2020YFC2004900)Multi-center RCT Clinical Project of the National Clinical Research Centre for Geriatric Diseases,Chinese PLA General Hospital(No.NCRCG-PLAGH-2023001)The Open Project of the National Clinical Research Centre for Geriatric Diseases,Chinese PLA General Hospital(No.NCRCG-PLAGH-2022016).
文摘Background and Objectives:Malnutrition is associated with a higher risk of osteoporosis.We aim to assess the relationship between serum albumin with geriatric nutritional risk index and osteopenia in Chinese elderly men.Methods and S tudy Design:This is a nested case-control study from a prospective cohort enrolled 1109 indi viduals who were followed for seven years.Demographic data,medical history,signs and symptoms,and labora tory parameters were collected and analysed.Nutritional status and Geriatric Nutritional Risk Index(GNRI)were assessed.The nutrition-related indexes predictive value for osteopenia development was analyzed through multi variate Cox regression analysis and by creating a receiver operating characteristic curve(ROC),calculating the area under the curve(AUC).Kaplan-Meier(K-M)method was further used to find the nutritional status level in the elderly men.Results:The ALB and GNRI correlated with the risk of osteopenia in Chinese elderly men.Af ter adjusting for all covariates,people with higher ALB level(HR:0.821;95%CI:0.790-0.852)and higher GNRI score(HR:0.889;95%CI:0.869-0.908)had a smaller risk of o steopenia.ROC analysis showed that the AUC for ALB was 0.729(p˂0.05)and for the GNRI score was 0.731(p˂0.05).K-M curve indicated a significant difference in ALB level(p˂0.001)and GNRI score(p˂0.001)in the respective subgroups.Conclusions:This study found that lower ALB level and lower GNRI score are associat ed with a higher prevalence of osteopenia among elderly men in China.
