Erratum to:Nano Research,2024,17(7):6332-6341.https://doi.org/10.1007/s12274-024-6547-z.One of the authors’affiliations,Sino-Danish College,Sino-Danish Center for Education and Research,University of Chinese Academy ...Erratum to:Nano Research,2024,17(7):6332-6341.https://doi.org/10.1007/s12274-024-6547-z.One of the authors’affiliations,Sino-Danish College,Sino-Danish Center for Education and Research,University of Chinese Academy of Sciences,Beijing 100049,China,was unfortunately omitted.And the online version of this paper is corrected.展开更多
In the domain of data governance,crimes involving virtual currencies have emerged as an integral concern that cannot be overlooked.To address challenges such as the difficulty of evidence col-lection and the low proba...In the domain of data governance,crimes involving virtual currencies have emerged as an integral concern that cannot be overlooked.To address challenges such as the difficulty of evidence col-lection and the low probability of recovering stolen funds in virtual currency crimes,this paper proposes a new mechanism for the electronic storage and retrieval of evidence using blockchain technology,elab-orating on its core steps and underlying technology.Moreover,from the perspective of virtual currency transaction intermediaries,this study employs game theory to analyze the issue,constructing replicator dynamics equations,solving for the Jacobian matrix,and exploring the direction of game evolution and the factors influencing the decision-making of the participants.This analysis demonstrates that the decision-making of virtual currency criminals is impacted by this electronic evidence mechanism,which can deter illicit intermediaries from assisting in money laundering activities,thereby reducing the fea-sibility of committing crimes with virtual currencies.Lastly,the paper offers policy recommendations to enhance the implement ability of the evidence storage and retrieval mechanism in regulating virtual currency crimes.展开更多
t Osteoarthritis(OA)is a common chronic joint disease characterized by articular cartilage degeneration,subchondral sclerosis,synovitis,and osteophyte formation.OA is asso-ciated with disability and impaired quality o...t Osteoarthritis(OA)is a common chronic joint disease characterized by articular cartilage degeneration,subchondral sclerosis,synovitis,and osteophyte formation.OA is asso-ciated with disability and impaired quality of life,particularly among the elderly.Leptin,a 16-kD non-glycosylated protein encoded by the obese gene,is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee.The metabolic mech-anisms employed by leptin in OA development have been widely studied,with attention being paid to aging as a corroborative risk factor for OA.Hence,in this review,we have attempted to establish a potential link between leptin and OA,by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mecha-nisms of OA that may provide fruitful guidance and emphasis for future research.展开更多
Atherosclerosis is an inflammatory disease that may cause severe heart disease and stroke.Current pharmacotherapy for atherosclerosis shows limited benefits.In the progression of atherosclerosis,monocyte adhesions and...Atherosclerosis is an inflammatory disease that may cause severe heart disease and stroke.Current pharmacotherapy for atherosclerosis shows limited benefits.In the progression of atherosclerosis,monocyte adhesions and inflammatory macrophages play vital roles.However,precise regulations of inflammatory immune microenvironments in pathological tissues remain challenging.Here,we report an atherosclerotic plaque-targeted selenopeptide nanomedicine for inhibiting atherosclerosis progression by reducing monocyte adhesions and inflammation of macrophages.The targeted nanomedicine has 2.2-fold enhancement in atherosclerotic lesion accumulation.The oxidation-responsibility of selenopeptide enables eliminations of reactive oxygen species and specific release of anti-inflammatory drugs,thereby reducing inflammation responses of macrophages.Notably,we find the oxidative metabolite of selenopeptide,octadecyl selenite,can bind to P-selectin in a high affinity with a dissociation constant of 1.5μM.This in situ generated active seleno-species further inhibit monocyte adhesions for anti-inflammation in synergy.With local regulations of monocyte adhesions and inflammations,the selenopeptide nanomedicine achieves 2.6-fold improvement in atherosclerotic plaque inhibition compared with simvastatin in the atherosclerosis mouse model.Meanwhile,the selenopeptide nanomedicine also displays excellent biological safety in both mice and rhesus monkeys.This study provides a safe and effective platform for regulating inflammatory immune microenvironments for inflammatory diseases such as atherosclerosis.展开更多
Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical applications.However,administered nanoparticles are rapidly sequestered and cleared by cells of the mononuclear phagocyte sy...Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical applications.However,administered nanoparticles are rapidly sequestered and cleared by cells of the mononuclear phagocyte system(MPS).In this study,we developed a biomimetic nanosystem that is able to efficiently escape MPS and target tumor tissues.The fabricated nanoparticles(TM-CQ/NPs)were coated with fibroblast cell membrane expressing tumor necrosis factor(TNF)-related apoptosis inducing ligand(TRAIL).Coating with this functionalized membrane reduced the endocytosis of nanoparticles by macrophages,but increased the nanoparticle uptake in tumor cells.Importantly,this membrane coating specifically induced tumor cell apoptosis via the interaction of TRAIL and its cognate death receptors.Meanwhile,the encapsulated chloroquine(CQ)further suppressed the uptake of nanoparticles by macrophages,and synergized with TRAIL to induce tumor cell apoptosis.The vigorous antitumor efficacy in two mice tumor models confirmed our nanosystem was an effective approach to address the MPS challenge for cancer therapy.Together,our TM-CQ/NPs nanosystem provides a feasible approach to precisely target tumor tissues and improve anticancer efficacy.展开更多
文摘Erratum to:Nano Research,2024,17(7):6332-6341.https://doi.org/10.1007/s12274-024-6547-z.One of the authors’affiliations,Sino-Danish College,Sino-Danish Center for Education and Research,University of Chinese Academy of Sciences,Beijing 100049,China,was unfortunately omitted.And the online version of this paper is corrected.
基金Supported by the National Natural Science Foundation of China(72274010,71932002,71904010)。
文摘In the domain of data governance,crimes involving virtual currencies have emerged as an integral concern that cannot be overlooked.To address challenges such as the difficulty of evidence col-lection and the low probability of recovering stolen funds in virtual currency crimes,this paper proposes a new mechanism for the electronic storage and retrieval of evidence using blockchain technology,elab-orating on its core steps and underlying technology.Moreover,from the perspective of virtual currency transaction intermediaries,this study employs game theory to analyze the issue,constructing replicator dynamics equations,solving for the Jacobian matrix,and exploring the direction of game evolution and the factors influencing the decision-making of the participants.This analysis demonstrates that the decision-making of virtual currency criminals is impacted by this electronic evidence mechanism,which can deter illicit intermediaries from assisting in money laundering activities,thereby reducing the fea-sibility of committing crimes with virtual currencies.Lastly,the paper offers policy recommendations to enhance the implement ability of the evidence storage and retrieval mechanism in regulating virtual currency crimes.
基金supported by the National Key R&D Program of China (No.2019YFA0111900)the National Natural Science Foundation of China (No.81874030,82072506)+8 种基金the National Clinical Research Center for Geriatric Disorders (China) (No.2021LNJJ05)the Provincial Key R&D Program of Hunan,China (No.2020SK2075)the Administration of Traditional Chinese Medicine of Hunan Province,China (No.2021075)the Innovation-Driven Project of Central South University (China) (No.2020CX045)Hunan Yong Talents of Science and Technology (China) (No.2021RC3025)Wu Jieping Medical Foundation (No.320.6750.2020-03-14)the Independent Exploration,Innovation Project for Postgraduate Students of Central South University (China) (No.2021zzts1024)the Hunan Provincial Innovation Foundation for Postgraduate (China) (No.CX20210360)Guangdong Basic and Applied Basic Research Foundation (China) (No.2021A1515220030).
文摘t Osteoarthritis(OA)is a common chronic joint disease characterized by articular cartilage degeneration,subchondral sclerosis,synovitis,and osteophyte formation.OA is asso-ciated with disability and impaired quality of life,particularly among the elderly.Leptin,a 16-kD non-glycosylated protein encoded by the obese gene,is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee.The metabolic mech-anisms employed by leptin in OA development have been widely studied,with attention being paid to aging as a corroborative risk factor for OA.Hence,in this review,we have attempted to establish a potential link between leptin and OA,by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mecha-nisms of OA that may provide fruitful guidance and emphasis for future research.
基金financially supported by the National Natural Science Foundation of China(Nos.51890892,22175048,22007024,and 21805058)National Key R&D Program of China(No.2018YFE0205400)Beijing Natural Science Foundation(No.2232072).
文摘Atherosclerosis is an inflammatory disease that may cause severe heart disease and stroke.Current pharmacotherapy for atherosclerosis shows limited benefits.In the progression of atherosclerosis,monocyte adhesions and inflammatory macrophages play vital roles.However,precise regulations of inflammatory immune microenvironments in pathological tissues remain challenging.Here,we report an atherosclerotic plaque-targeted selenopeptide nanomedicine for inhibiting atherosclerosis progression by reducing monocyte adhesions and inflammation of macrophages.The targeted nanomedicine has 2.2-fold enhancement in atherosclerotic lesion accumulation.The oxidation-responsibility of selenopeptide enables eliminations of reactive oxygen species and specific release of anti-inflammatory drugs,thereby reducing inflammation responses of macrophages.Notably,we find the oxidative metabolite of selenopeptide,octadecyl selenite,can bind to P-selectin in a high affinity with a dissociation constant of 1.5μM.This in situ generated active seleno-species further inhibit monocyte adhesions for anti-inflammation in synergy.With local regulations of monocyte adhesions and inflammations,the selenopeptide nanomedicine achieves 2.6-fold improvement in atherosclerotic plaque inhibition compared with simvastatin in the atherosclerosis mouse model.Meanwhile,the selenopeptide nanomedicine also displays excellent biological safety in both mice and rhesus monkeys.This study provides a safe and effective platform for regulating inflammatory immune microenvironments for inflammatory diseases such as atherosclerosis.
基金supported by the National Natural Science Foundation of China(Nos.32101128,21975218,and 51773176)the National Key Research and Development Program of China(2019YFA0802202)the 111 Project(B13026,China)。
文摘Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical applications.However,administered nanoparticles are rapidly sequestered and cleared by cells of the mononuclear phagocyte system(MPS).In this study,we developed a biomimetic nanosystem that is able to efficiently escape MPS and target tumor tissues.The fabricated nanoparticles(TM-CQ/NPs)were coated with fibroblast cell membrane expressing tumor necrosis factor(TNF)-related apoptosis inducing ligand(TRAIL).Coating with this functionalized membrane reduced the endocytosis of nanoparticles by macrophages,but increased the nanoparticle uptake in tumor cells.Importantly,this membrane coating specifically induced tumor cell apoptosis via the interaction of TRAIL and its cognate death receptors.Meanwhile,the encapsulated chloroquine(CQ)further suppressed the uptake of nanoparticles by macrophages,and synergized with TRAIL to induce tumor cell apoptosis.The vigorous antitumor efficacy in two mice tumor models confirmed our nanosystem was an effective approach to address the MPS challenge for cancer therapy.Together,our TM-CQ/NPs nanosystem provides a feasible approach to precisely target tumor tissues and improve anticancer efficacy.
