As the mimic biology becomes more and more important in the field of technology, superhydrophobic materials in the natural world have also become common. Superhydrophobic surfaces are used to prevent water droplets fr...As the mimic biology becomes more and more important in the field of technology, superhydrophobic materials in the natural world have also become common. Superhydrophobic surfaces are used to prevent water droplets from wetting themselves which contain the micro- and nano-structures named hierarchical surfaces and exhibit the high water contact angles (WCA) that are greater than 150˚and perfect application foreground in both our daily lives and industry. In this work, we first discuss several surface properties and their numerical models. And then we list the surface properties of a variety of natural superhydrophobic surfaces and sum up their similarities and differences. The most recent strategies of how to apply natural superhydrophobic surfaces are also introduced within the past several years. In addition, we talk about the limitations of the current generation of superhydrophobic surfaces and prospects which looks for solutions to the problems. This review aims to enable researchers to learn more about the principles and mechanisms of superhydrophobicity and perceive the new methods for creating and modifying it.展开更多
Heart failure resulting from myocardial infarction(MI)is a leading global health concern.Current revasculari-zation therapies cannot fully restore the infarcted myocardium or prevent maladaptive ventricular remodeling...Heart failure resulting from myocardial infarction(MI)is a leading global health concern.Current revasculari-zation therapies cannot fully restore the infarcted myocardium or prevent maladaptive ventricular remodeling.Traditional Chinese medicine with its multitarget regulation and favorable biosafety shows a promising thera-peutic potential.Tanshinone IIA(TIIA)and formononetin(FM),two bioactive compounds derived from Salvia miltiorrhiza and Astragalus membranaceus,respectively,exhibit antioxidant,anti-inflammatory,and proangio-genic effects.Herein,a neutrophil-targeted nanomedicine(TF-5NP)was developed to deliver TIIA and FM to the infarcted myocardium for mitigating oxidative damage and promoting angiogenesis.TF-5NP was synthesized by coassembling bis-5-hydroxytryptamine-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly-ethylene glycol-carboxylic acid with cholesterol and lipid 1,2-distearoyl-sn-glycero-3-phosphoglycerol,which binds to troponin in the infarcted myocardium.This nanomedicine reduces inflammation and cardiomyocyte damage and improves cardiac function in porcine MI models,with therapeutic effects lasting for~28 d.These findings suggest that TF-5NP use is a promising approach for treating post-MI maladaptive remodeling and heart failure.展开更多
This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction phase.The determination of neutrino mass ordering in JUNO requires an ...This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction phase.The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV.To achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the JUNO detector.Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction algorithm.To account for these effects,a full JUNO simulation and reconstruction approach is employed.This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution.The results of this study reveal an energy resolution of 2.95% at 1 Mev.Furthermore,this study assesses the contribution of major effects to the overall energy resolution budget.This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data collection.Moreover,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.展开更多
The Jiangmen Underground Neutrino Observatory(JUNO)is a multi-purpose neutrino experiment under construction in South China.This paper presents an updated estimate of JUNO’s sensitivity to neutrino mass ordering usin...The Jiangmen Underground Neutrino Observatory(JUNO)is a multi-purpose neutrino experiment under construction in South China.This paper presents an updated estimate of JUNO’s sensitivity to neutrino mass ordering using the reactor antineutrinos emitted from eight nuclear reactor cores in the Taishan and Yangjiang nuclear power plants.This measurement is planned by studying the fine interference pattern caused by quasi-vacuum oscillations in the oscillated antineutrino spectrum at a baseline of 52.5 km and is completely independent of the CP violating phase and neutrino mixing angleθ_(23).The sensitivity is obtained through a joint analysis of JUNO and Taishan Antineutrino Observatory(TAO)detectors utilizing the best available knowledge to date about the location and overburden of the JUNO experimental site,local and global nuclear reactors,JUNO and TAO detector responses,expected event rates and spectra of signals and backgrounds,and systematic uncertainties of analysis inputs.We find that a 3σmedian sensitivity to reject the wrong mass ordering hypothesis can be reached with an exposure of about 6.5 years×26.6 GW thermal power.展开更多
JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)...JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the experiment.The sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite detector.It is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data collection.In the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering hypothesis.The new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.展开更多
Data with large dimensions will bring various problems to the application of data envelopment analysis(DEA).In this study,we focus on a“big data”problem related to the considerably large dimensions of the input-outp...Data with large dimensions will bring various problems to the application of data envelopment analysis(DEA).In this study,we focus on a“big data”problem related to the considerably large dimensions of the input-output data.The four most widely used approaches to guide dimension reduction in DEA are compared via Monte Carlo simulation,including principal component analysis(PCA-DEA),which is based on the idea of aggregating input and output,efficiency contribution measurement(ECM),average efficiency measure(AEC),and regression-based detection(RB),which is based on the idea of variable selection.We compare the performance of these methods under different scenarios and a brand-new comparison benchmark for the simulation test.In addition,we discuss the effect of initial variable selection in RB for the first time.Based on the results,we offer guidelines that are more reliable on how to choose an appropriate method.展开更多
Diabetes characterized by hyperglycemia is a chronic metabolic disease with increasing prevalence worldwide,and over time it leads to damage to various organs including the liver.As the liver is the major organ for gl...Diabetes characterized by hyperglycemia is a chronic metabolic disease with increasing prevalence worldwide,and over time it leads to damage to various organs including the liver.As the liver is the major organ for glucose metabolism,patients with diabetes are prone to liver injuries or damages;and without timely and effective treatment,diabetic liver injury may further deteriorate into serious or lifethreatening complications including liver cancer or liver failure.Hence,the accurate detection of diabetic liver injury is of great significance for diabetic patients in terms of improving quality of life.Herein,a fluorescent probe(TTX-P)has been developed for in situ detection and imaging of diabetic liver injury in the near-infrared second-window(NIR-II)region.In routine clinical practice,alkaline phosphatase(ALP)is one of the most commonly assayed enzymes,and thus serving as an important diagnostic biomarker for liver dysfunction or injury.The probe TTX-P responds in situ to the overexpressed ALP in liver and thus giving out strong NIR-II fluorescence as the reporting signals for detection and imaging.The NIR-II probe TTX-P consists of the NIR-II chromophore TTX-OH as the fluorophore and phosphate group as the responsive unit.Without the presence of ALP,the probe TTX-P displays weak fluorescence because the electron-withdrawing phosphate group weakens the electron-pushing capability of the electron-donor side of the NIR-II fluorophore.While in the presence of ALP,the phosphate group is cleaved by the enzyme and consequently the fluorophore emits evident NIR-II fluorescence.The probe TTX-P has been applied in imaging liver injury in diabetic mice.The approach provides a utilitarian means for visualizing detection of diabetic liver injury in mice with NIR-II fluorescence imaging.展开更多
文摘As the mimic biology becomes more and more important in the field of technology, superhydrophobic materials in the natural world have also become common. Superhydrophobic surfaces are used to prevent water droplets from wetting themselves which contain the micro- and nano-structures named hierarchical surfaces and exhibit the high water contact angles (WCA) that are greater than 150˚and perfect application foreground in both our daily lives and industry. In this work, we first discuss several surface properties and their numerical models. And then we list the surface properties of a variety of natural superhydrophobic surfaces and sum up their similarities and differences. The most recent strategies of how to apply natural superhydrophobic surfaces are also introduced within the past several years. In addition, we talk about the limitations of the current generation of superhydrophobic surfaces and prospects which looks for solutions to the problems. This review aims to enable researchers to learn more about the principles and mechanisms of superhydrophobicity and perceive the new methods for creating and modifying it.
基金supported by the National Natural Science Founda-tion of China(Grant Nos.82274271&82104962&82004112)Guang-dong Basic and Applied Basic Research Foundation(Grant Nos.2024B1515020033&2024A1515011686&2023A1515220029)+6 种基金Outstanding Young Talents Youth Program of Guangdong Hospital of Chinese Medicine(Grant No.SZ2023QNO1)Guangzhou Science and Technology Fund(202201020565)Major Science and Technology Projects of Chinese Medicine in Guangzhou Region(2025CX010,2025QN010)the 2023 Young Top Talent Cultivation“Unveiling the List of Commander-in-Chief”Project Program of Guangzhou University of Chinese Medicine(to Shuai MAO)Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine,The Second Affiliated Hos-pital of Guangzhou University of Chinese Medicine(SZ2024KF01)Guangzhou Science and Technology Plan(2024A04J3304)Guangzhou Municipal Science and Technology Bureau-Academia Joint Funding Program(2024A03J0062).
文摘Heart failure resulting from myocardial infarction(MI)is a leading global health concern.Current revasculari-zation therapies cannot fully restore the infarcted myocardium or prevent maladaptive ventricular remodeling.Traditional Chinese medicine with its multitarget regulation and favorable biosafety shows a promising thera-peutic potential.Tanshinone IIA(TIIA)and formononetin(FM),two bioactive compounds derived from Salvia miltiorrhiza and Astragalus membranaceus,respectively,exhibit antioxidant,anti-inflammatory,and proangio-genic effects.Herein,a neutrophil-targeted nanomedicine(TF-5NP)was developed to deliver TIIA and FM to the infarcted myocardium for mitigating oxidative damage and promoting angiogenesis.TF-5NP was synthesized by coassembling bis-5-hydroxytryptamine-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly-ethylene glycol-carboxylic acid with cholesterol and lipid 1,2-distearoyl-sn-glycero-3-phosphoglycerol,which binds to troponin in the infarcted myocardium.This nanomedicine reduces inflammation and cardiomyocyte damage and improves cardiac function in porcine MI models,with therapeutic effects lasting for~28 d.These findings suggest that TF-5NP use is a promising approach for treating post-MI maladaptive remodeling and heart failure.
基金Supported by the Chinese Academy of Sciencesthe National Key R&D Program of China+20 种基金the CAS Center for Excellence in Particle Physics,Wuyi Universitythe Tsung-Dao Lee Institute of Shanghai Jiao Tong University in Chinathe Institut National de Physique Nucléaire et de Physique de Particules(IN2P3)in Francethe Istituto Nazionale di Fisica Nucleare(INFN)in Italythe Italian-Chinese collaborative research program MAECI-NSFCthe Fond de la Recherche Scientifique(F.R.S-FNRS)FWO under the"Excellence of Science-EOS"in Belgiumthe Conselho Nacional de Desenvolvimento Científico e Tecnològico in Brazilthe Agencia Nacional de Investigacion y Desarrollo and ANID Millennium Science Initiative Program—ICN2019_044 in Chilethe Charles University Research Centre and the Ministry of Education,Youth,and Sports in Czech Republicthe Deutsche Forschungsgemeinschaft(DFG)the Helmholtz Associationthe Cluster of Excellence PRISMA+in Germanythe Joint Institute of Nuclear Research(JINR)Lomonosov Moscow State University in Russiathe joint Russian Science Foundation(RSF)National Natural Science Foundation of China(NSFC)research programthe MOST and MOE in Taiwan,Chinathe Chulalongkorn University and Suranaree University of Technology in Thailandthe University of California at Irvinethe National Science Foundation in USA。
文摘This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction phase.The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV.To achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the JUNO detector.Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction algorithm.To account for these effects,a full JUNO simulation and reconstruction approach is employed.This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution.The results of this study reveal an energy resolution of 2.95% at 1 Mev.Furthermore,this study assesses the contribution of major effects to the overall energy resolution budget.This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data collection.Moreover,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.
基金Supported by the Chinese Academy of Sciences,the National Key R&D Program of Chinathe CAS Center for Excellence in Particle Physics,Wuyi University,and the TsungDao Lee Institute of Shanghai Jiao Tong University in China+3 种基金the Institut National de Physique Nucléaire et de Physique de Particules(IN2P3)in Francethe Istituto Nazionale di Fisica Nucleare(INFN)in Italy,the Italian-Chinese collaborative research program MAECI-NSFC,the Fond de la Recherche Scientifique(F.R.S-FNRS)and FWO under the“Excellence of Science–EOS”in Belgium,the Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnol`ogico in Brazil,the Agencia Nacional de Investigacion y Desarrollo and ANID-Millennium Science Initiative Program-ICN2019_044 in Chilethe Charles University Research Centre and the Ministry of Education,Youth,and Sports in Czech Republic,the Deutsche Forschungsgemeinschaft(DFG)the Helmholtz Association,and the Cluster of Excellence PRISMA+in Germany,the Joint Institute of Nuclear Research(JINR)and Lomonosov Moscow State University in Russia,the joint Russian Science Foundation(RSF)and National Natural Science Foundation of China(NSFC)research program,the MOST and MOE in Taiwan,China,the Chulalongkorn University and Suranaree University of Technology in Thailand,University of California at Irvine and the National Science Foundation in the US。
文摘The Jiangmen Underground Neutrino Observatory(JUNO)is a multi-purpose neutrino experiment under construction in South China.This paper presents an updated estimate of JUNO’s sensitivity to neutrino mass ordering using the reactor antineutrinos emitted from eight nuclear reactor cores in the Taishan and Yangjiang nuclear power plants.This measurement is planned by studying the fine interference pattern caused by quasi-vacuum oscillations in the oscillated antineutrino spectrum at a baseline of 52.5 km and is completely independent of the CP violating phase and neutrino mixing angleθ_(23).The sensitivity is obtained through a joint analysis of JUNO and Taishan Antineutrino Observatory(TAO)detectors utilizing the best available knowledge to date about the location and overburden of the JUNO experimental site,local and global nuclear reactors,JUNO and TAO detector responses,expected event rates and spectra of signals and backgrounds,and systematic uncertainties of analysis inputs.We find that a 3σmedian sensitivity to reject the wrong mass ordering hypothesis can be reached with an exposure of about 6.5 years×26.6 GW thermal power.
基金Supported by the Chinese Academy of Sciencesthe National Key R&D Program of China+18 种基金the CAS Center for Excellence in Particle Physics,Wuyi Universitythe Tsung-Dao Lee Institute of Shanghai Jiao Tong University in Chinathe Institut National de Physique Nucléaire et de Physique de Particules(IN2P3)in Francethe Istituto Nazionale di Fisica Nucleare(INFN)in Italythe Italian-Chinese collaborative research program MAECI-NSFCthe Fond de la Recherche Scientifique(F.R.S-FNRS)FWO under the“Excellence of Science-EOS in Belgium”the Conselho Nacional de Desenvolvimento Científico e Tecnològico in Brazilthe Agencia Nacional de Investigacion y Desarrollo and ANID-Millennium Science Initiative Program-ICN2019_044 in Chilethe Charles University Research Centre and the Ministry of Education,Youth,and Sports in Czech Republicthe Deutsche Forschungsgemeinschaft(DFG)the Helmholtz Associationthe Cluster of Excellence PRISMA+in Germanythe Joint Institute of Nuclear Research(JINR)and Lomonosov Moscow State University in Russiathe joint Russian Science Foundation(RSF)National Natural Science Foundation of China(NSFC)research programthe MOST and MOE in Taiwanthe Chulalongkorn University and Suranaree University of Technology in Thailand,University of California at Irvinethe National Science Foundation in USA。
文摘JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the experiment.The sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite detector.It is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data collection.In the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering hypothesis.The new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.
文摘Data with large dimensions will bring various problems to the application of data envelopment analysis(DEA).In this study,we focus on a“big data”problem related to the considerably large dimensions of the input-output data.The four most widely used approaches to guide dimension reduction in DEA are compared via Monte Carlo simulation,including principal component analysis(PCA-DEA),which is based on the idea of aggregating input and output,efficiency contribution measurement(ECM),average efficiency measure(AEC),and regression-based detection(RB),which is based on the idea of variable selection.We compare the performance of these methods under different scenarios and a brand-new comparison benchmark for the simulation test.In addition,we discuss the effect of initial variable selection in RB for the first time.Based on the results,we offer guidelines that are more reliable on how to choose an appropriate method.
基金supported by the National Natural Science Foundation of China(Grant Nos.22274057 and 21875069)the Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates(Grant No.2019B030301003).
文摘Diabetes characterized by hyperglycemia is a chronic metabolic disease with increasing prevalence worldwide,and over time it leads to damage to various organs including the liver.As the liver is the major organ for glucose metabolism,patients with diabetes are prone to liver injuries or damages;and without timely and effective treatment,diabetic liver injury may further deteriorate into serious or lifethreatening complications including liver cancer or liver failure.Hence,the accurate detection of diabetic liver injury is of great significance for diabetic patients in terms of improving quality of life.Herein,a fluorescent probe(TTX-P)has been developed for in situ detection and imaging of diabetic liver injury in the near-infrared second-window(NIR-II)region.In routine clinical practice,alkaline phosphatase(ALP)is one of the most commonly assayed enzymes,and thus serving as an important diagnostic biomarker for liver dysfunction or injury.The probe TTX-P responds in situ to the overexpressed ALP in liver and thus giving out strong NIR-II fluorescence as the reporting signals for detection and imaging.The NIR-II probe TTX-P consists of the NIR-II chromophore TTX-OH as the fluorophore and phosphate group as the responsive unit.Without the presence of ALP,the probe TTX-P displays weak fluorescence because the electron-withdrawing phosphate group weakens the electron-pushing capability of the electron-donor side of the NIR-II fluorophore.While in the presence of ALP,the phosphate group is cleaved by the enzyme and consequently the fluorophore emits evident NIR-II fluorescence.The probe TTX-P has been applied in imaging liver injury in diabetic mice.The approach provides a utilitarian means for visualizing detection of diabetic liver injury in mice with NIR-II fluorescence imaging.
