An efficient rhodium(Ⅱ)-catalyzed[4+3]cyclization reaction of 1-sulfonyl-1,2-3-triazoles and indoles was developed.Azepino[5,4,3-ccflindoles,which are widely distributed in ergot alkaloids with various biological act...An efficient rhodium(Ⅱ)-catalyzed[4+3]cyclization reaction of 1-sulfonyl-1,2-3-triazoles and indoles was developed.Azepino[5,4,3-ccflindoles,which are widely distributed in ergot alkaloids with various biological activities,could be obtained in good to excellent yields.In addition,the total synthesis of(±)-aurantioclavine was completed in four steps from the known compound 1a adopting this[4+3]cyclization as a key step.展开更多
基金the National Natural Science Foundation of China(Nos.21871235,21901230,21801224)the Natural Science Foundation of Zhejiang Province(No.LQ18B020009)+1 种基金the Fundamental Research Funds of Zhejiang Sci-Tech University(2019Y003)the Science Foundation of Zhejiang Sci-Tech University(ZSTU)under Grant No.18062301-Y is gratefully acknowledged.
文摘An efficient rhodium(Ⅱ)-catalyzed[4+3]cyclization reaction of 1-sulfonyl-1,2-3-triazoles and indoles was developed.Azepino[5,4,3-ccflindoles,which are widely distributed in ergot alkaloids with various biological activities,could be obtained in good to excellent yields.In addition,the total synthesis of(±)-aurantioclavine was completed in four steps from the known compound 1a adopting this[4+3]cyclization as a key step.
