The photovoltaic(PV)water electrolysis method currently stands as the most promising approach for green hydrogen production.The rapid iteration of photovoltaic technologies has significantly affected on the technical ...The photovoltaic(PV)water electrolysis method currently stands as the most promising approach for green hydrogen production.The rapid iteration of photovoltaic technologies has significantly affected on the technical and economic evaluation for photovoltaic hydrogen production.In this work,the photovoltaic hydrogen production of three most advanced silicon photovoltaic technologies is systematically compared for the first time under the climatic conditions of the Kucha region.All-weather stable hydrogen production control system with optimal charging and discharging strategies is constructed to realize stable and efficient hydrogen energy production.Seven machine learning(ML)algorithms are used to forecast the performance in power generation and hydrogen production of a 100 MW photovoltaic hydrogen production and energy storage(PH-S)system throughout its operational life.The long short-term memory(LSTM)algorithm exhibits the best performance,achieving mean absolute error(MAE)of 0.0415,root mean square error(RMSE)of 0.0891,and coefficient of determination(R2)of 0.8402.In terms of cost-effectiveness,heterojunction with intrinsic thin layer(HJT)PV technology achieves the lowest levelized cost of electricity(LCOE)and hydrogen(LCOH)at 0.025$/kWh and 6.95$/kg,respectively.According to the sensitivity analysis,when the cost of proton exchange membrane electrolysis(PEMEC)reduced 50%,the LCOH for PH-S system decreased 21.40%.This study provides valuable insights for the practical implementation of large-scale photovoltaic hydrogen production and cost reduction in PH-S systems.展开更多
There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.In this...There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.In this study,as a representative of extracellular polymeric substance,the effect of sodium alginate(SA)on phosphorus recovery by vivianite precipitation under different initial SA concentrations(0–800 mg/L),p H values(6.5–9.0)and Fe/P molar ratios(1:1–2.4:1)was investigated using synthetic wastewater.The results showed that SA in low concentrations(≤400 mg/L)had little inhibitory effect on the phosphorus recovery rate.However,when the concentration of SA was larger than 400 mg/L,the phosphorus recovery rate decreased significantly with increasing SA concentrations.The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial p H and Fe/P molar ratios.Additionally,SA has no obvious influence on the composition of products,but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.展开更多
Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncR...Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge.By RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA.LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion.Silencing of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite effects.Mechanistically,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and SSTR3.ChIRP-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for LLNLR-299G3.1.Rescue experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and TNFRSF4.Therapeutically,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in vivo.Overall,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC.展开更多
Tuberculosis(TB)remains a major cause of morbidity and mortality worldwide,particularly in developing countries.A rapid and efficient method for TB diagnosis is indispensable to check the trend of tuberculosis expansi...Tuberculosis(TB)remains a major cause of morbidity and mortality worldwide,particularly in developing countries.A rapid and efficient method for TB diagnosis is indispensable to check the trend of tuberculosis expansion.The emergence of drug-resistant bacteria has increased the challenge of rapid drug resistance tests.Due to its high specificity and sensitivity,bacteriophage-based diagnosis is intensively pursued.In this review,we mainly described mycobacteriophage-based diagnosis in TB detection,especially two prevalent approaches:fluorescent reporter phage and phage amplified biologically assay(PhaB).The rationale of reporter phage is that phage carrying fluorescent genes can infect host bacteria specifically.Phage amplified biological assay based on the principle that phages can infect the live Mycobacterium tuberculosis in the specimen under suitable conditions and produce plaques.Other phage-based diagnostic methods,such as a combination of the amplified biologically assay and nucleic acid amplification or lateral flow assays,are also actively explored.This review will help us improve the understanding of mycobacteriophages in TB detection and better promote the development of the rapid diagnosis of M.tuberculosis.展开更多
Prophages are temperate phages integrated into the host bacterial genome.They play an important role in the adaptation and the pathogenicity of bacteria,especially pathogenic bacteria.In this review,we described the d...Prophages are temperate phages integrated into the host bacterial genome.They play an important role in the adaptation and the pathogenicity of bacteria,especially pathogenic bacteria.In this review,we described the distribution of prophages in different hosts and different environments,and focused on the significance of prophages.At the singlecell level,prophages can help the host adapt to harsh external environments by directly carrying virulence genes,encoding regulatory factors and activating lysogeny.At the population level,prophages can influence the overall evolutionary direction and ecological function of the host bacterial community.This review will help us understand the important role of prophages as unique organisms in individual bacteria and microbial populations.展开更多
人工智能识别手势在认知神经科学和机械臂技术领域有着广泛的应用。最近,摄像头和应变传感器被用于收集不同手势的图片和随时间变化的响应数据,这些数据被输入人工神经网络进行识别。大量的输入数据会造成算力的浪费、大量的能源消耗和...人工智能识别手势在认知神经科学和机械臂技术领域有着广泛的应用。最近,摄像头和应变传感器被用于收集不同手势的图片和随时间变化的响应数据,这些数据被输入人工神经网络进行识别。大量的输入数据会造成算力的浪费、大量的能源消耗和明显的时间延迟。文章介绍了一种基于弯曲敏感石墨烯应变传感器和衍射深度神经网络(Diffraction Deep Neural Network,D2NN)的手势识别方法。应变传感器是通过激光划线技术在氧化石墨烯(Graphene Oxide,GO)薄膜上制备的,在弯曲角度调节下表现出可调的电流响应。10个应变传感器位于手指关节处,用于捕捉不同手势下的电流响应,并将其转换为10像素图像,作为衍射深度神经网络的输入。在3次迭代内,识别0~9数字手势的仿真准确率可达到100%。输入数据量仅为10个,远低于已报道的手势识别设备。石墨烯应变传感器与光学神经形态计算的结合,为实现低成本、高效率、高准确度的人机交互铺平了道路。展开更多
Wastewater is a breeding ground for many pathogens,which may pose a threat to human health through various water transmission pathways.Therefore,a simple and effective method is urgently required to monitor and treat ...Wastewater is a breeding ground for many pathogens,which may pose a threat to human health through various water transmission pathways.Therefore,a simple and effective method is urgently required to monitor and treat wastewater.As bacterial viruses,bacteriophages(phages)are the most widely distributed and abundant organisms in the biosphere.Owing to their capacity to specifically infect bacterial hosts,they have recently been used as novel tools in water pollution control.The purpose of this review is to summarize and evaluate the roles of phages in monitoring pathogens,tracking pollution sources,treating pathogenic bacteria,infecting bloom-forming cyanobacteria,and controlling bulking sludge and biofilm pollution in wastewater treatment systems.We also discuss the limitations of phage usage in water pollution control,including phage-mediated horizontal gene transfer,the evolution of bacterial resistance,and phage concentration decrease.This review provides an integrated outlook on the use of phages in water pollution control.展开更多
We report the superconductivity of a new quaternary compound ThMo_(2)Si_(2)C, synthesized with the arc-melting technique. The compound crystallizes in a tetragonal CeCr_(2)Si_(2)C-type structure with cell parameters o...We report the superconductivity of a new quaternary compound ThMo_(2)Si_(2)C, synthesized with the arc-melting technique. The compound crystallizes in a tetragonal CeCr_(2)Si_(2)C-type structure with cell parameters of a = 4.2296A and c = 5.3571 A. An interlayer Si–Si covalent bonding is suggested by the atomic distance. The electrical resistivity and magnetic susceptibility measurements indicate a Pauli-paramagnetic metal with dominant electron-electron scattering in the normal-state. Bulk superconductivity at 2.2 K is demonstrated with a dimensionless specific-heat jump of △C/γnT = 0.98. The superconducting parameters of the critical magnetic fields, coherence length, penetration depth, and superconducting energy gap are given.展开更多
In recent years,shutdown accidents caused by thyristor voltage monitoring(TVM)board failure have occurred several times in converter stations.With the increase of operation time,the working reliability problem of TVM ...In recent years,shutdown accidents caused by thyristor voltage monitoring(TVM)board failure have occurred several times in converter stations.With the increase of operation time,the working reliability problem of TVM board becomes a challenge to the safe operation.This paper studies the effects of pollution severity and relative humidity(RH)on the function of TVM board.The results show that the increase of RH can lead to the advance or even disappearance of check-back signals.Furthermore,the increase of pollution severity can decrease the failure RH threshold.Through simulation and equivalent experiment,it is verified that the resistance decrease of the voltage balancing resistor under the combined effect of contamination and RH is the main reason for the advance of check-back signals.According to the experiments,it is found that the upper surface contamination has a greater effect on the function of TVM board than the lower surface contamination,resulting in more decrease of the failure RH threshold.In addition,leakage current at different RH is also measured.Results show that the pulse peak of leakage current is closely related to check-back signals.When the pulse peak is too small or disappears,check-back signals also disappear,indicating that the TVM board fails.展开更多
基金support from the Sichuan Science and Technology Program(2022NSFSC0226)the Production-Education Integration Demonstration Project of Sichuan Province“Photovoltaic Industry Production-Education Integration Comprehensive Demonstration Base of Sichuan Province(Sichuan Financial Education[2022]No.106)”+2 种基金National Key Research and Development Program of China(2022YFB3803300,2023YFE0116800)Natural Science Foundation of Sichuan(2022NSFSC0023,23NSFSC0112)Supported by Sichuan Science and Technology Program(No.2023ZYD0163).
文摘The photovoltaic(PV)water electrolysis method currently stands as the most promising approach for green hydrogen production.The rapid iteration of photovoltaic technologies has significantly affected on the technical and economic evaluation for photovoltaic hydrogen production.In this work,the photovoltaic hydrogen production of three most advanced silicon photovoltaic technologies is systematically compared for the first time under the climatic conditions of the Kucha region.All-weather stable hydrogen production control system with optimal charging and discharging strategies is constructed to realize stable and efficient hydrogen energy production.Seven machine learning(ML)algorithms are used to forecast the performance in power generation and hydrogen production of a 100 MW photovoltaic hydrogen production and energy storage(PH-S)system throughout its operational life.The long short-term memory(LSTM)algorithm exhibits the best performance,achieving mean absolute error(MAE)of 0.0415,root mean square error(RMSE)of 0.0891,and coefficient of determination(R2)of 0.8402.In terms of cost-effectiveness,heterojunction with intrinsic thin layer(HJT)PV technology achieves the lowest levelized cost of electricity(LCOE)and hydrogen(LCOH)at 0.025$/kWh and 6.95$/kg,respectively.According to the sensitivity analysis,when the cost of proton exchange membrane electrolysis(PEMEC)reduced 50%,the LCOH for PH-S system decreased 21.40%.This study provides valuable insights for the practical implementation of large-scale photovoltaic hydrogen production and cost reduction in PH-S systems.
基金supported by the State Key Laboratory of Eco-hydraulics in the Northwest Arid Region of China(No.2016ZZKT-8)。
文摘There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.In this study,as a representative of extracellular polymeric substance,the effect of sodium alginate(SA)on phosphorus recovery by vivianite precipitation under different initial SA concentrations(0–800 mg/L),p H values(6.5–9.0)and Fe/P molar ratios(1:1–2.4:1)was investigated using synthetic wastewater.The results showed that SA in low concentrations(≤400 mg/L)had little inhibitory effect on the phosphorus recovery rate.However,when the concentration of SA was larger than 400 mg/L,the phosphorus recovery rate decreased significantly with increasing SA concentrations.The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial p H and Fe/P molar ratios.Additionally,SA has no obvious influence on the composition of products,but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
基金This study was approved by the Medical Ethics Committee of Shenzhen University Health Science Center(protocol no.2016001).
文摘Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge.By RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA.LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion.Silencing of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite effects.Mechanistically,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and SSTR3.ChIRP-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for LLNLR-299G3.1.Rescue experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and TNFRSF4.Therapeutically,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in vivo.Overall,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC.
基金the National Natural Science Foundation of China(31600148,81660331)the Foundation of University of Jinan(XBS1519,XKY1633)+2 种基金the Shandong Excellent Young Scientist Award Fund(BS2014YY031)High Level Innovation Teams of Guangxi Colleges&Universities/Outstanding Scholars Program(Guijiaoren[2018]35)Visiting Scholar Research Program of University of Jinan.
文摘Tuberculosis(TB)remains a major cause of morbidity and mortality worldwide,particularly in developing countries.A rapid and efficient method for TB diagnosis is indispensable to check the trend of tuberculosis expansion.The emergence of drug-resistant bacteria has increased the challenge of rapid drug resistance tests.Due to its high specificity and sensitivity,bacteriophage-based diagnosis is intensively pursued.In this review,we mainly described mycobacteriophage-based diagnosis in TB detection,especially two prevalent approaches:fluorescent reporter phage and phage amplified biologically assay(PhaB).The rationale of reporter phage is that phage carrying fluorescent genes can infect host bacteria specifically.Phage amplified biological assay based on the principle that phages can infect the live Mycobacterium tuberculosis in the specimen under suitable conditions and produce plaques.Other phage-based diagnostic methods,such as a combination of the amplified biologically assay and nucleic acid amplification or lateral flow assays,are also actively explored.This review will help us improve the understanding of mycobacteriophages in TB detection and better promote the development of the rapid diagnosis of M.tuberculosis.
基金the National Natural Science Foundation(31600148)the Shandong Excellent Young Scientist Award Fund(BS2014YY031).
文摘Prophages are temperate phages integrated into the host bacterial genome.They play an important role in the adaptation and the pathogenicity of bacteria,especially pathogenic bacteria.In this review,we described the distribution of prophages in different hosts and different environments,and focused on the significance of prophages.At the singlecell level,prophages can help the host adapt to harsh external environments by directly carrying virulence genes,encoding regulatory factors and activating lysogeny.At the population level,prophages can influence the overall evolutionary direction and ecological function of the host bacterial community.This review will help us understand the important role of prophages as unique organisms in individual bacteria and microbial populations.
文摘人工智能识别手势在认知神经科学和机械臂技术领域有着广泛的应用。最近,摄像头和应变传感器被用于收集不同手势的图片和随时间变化的响应数据,这些数据被输入人工神经网络进行识别。大量的输入数据会造成算力的浪费、大量的能源消耗和明显的时间延迟。文章介绍了一种基于弯曲敏感石墨烯应变传感器和衍射深度神经网络(Diffraction Deep Neural Network,D2NN)的手势识别方法。应变传感器是通过激光划线技术在氧化石墨烯(Graphene Oxide,GO)薄膜上制备的,在弯曲角度调节下表现出可调的电流响应。10个应变传感器位于手指关节处,用于捕捉不同手势下的电流响应,并将其转换为10像素图像,作为衍射深度神经网络的输入。在3次迭代内,识别0~9数字手势的仿真准确率可达到100%。输入数据量仅为10个,远低于已报道的手势识别设备。石墨烯应变传感器与光学神经形态计算的结合,为实现低成本、高效率、高准确度的人机交互铺平了道路。
基金the National Key Research and Development Program of China(No.2018YFA0903000)the National Natural Science Foundation of China(Grant Nos.31600148,31870105 and 31741007)+2 种基金the Foundation of University of Jinan(Nos.XBS1519,XKY1633 and XKY2008)High Level Innovation Teams of Guangxi Colleges&Universities/Outstanding Scholars Program(Guijiaoren(2018)35)Visiting Scholar Research Program of University of Jinan.
文摘Wastewater is a breeding ground for many pathogens,which may pose a threat to human health through various water transmission pathways.Therefore,a simple and effective method is urgently required to monitor and treat wastewater.As bacterial viruses,bacteriophages(phages)are the most widely distributed and abundant organisms in the biosphere.Owing to their capacity to specifically infect bacterial hosts,they have recently been used as novel tools in water pollution control.The purpose of this review is to summarize and evaluate the roles of phages in monitoring pathogens,tracking pollution sources,treating pathogenic bacteria,infecting bloom-forming cyanobacteria,and controlling bulking sludge and biofilm pollution in wastewater treatment systems.We also discuss the limitations of phage usage in water pollution control,including phage-mediated horizontal gene transfer,the evolution of bacterial resistance,and phage concentration decrease.This review provides an integrated outlook on the use of phages in water pollution control.
基金supported by the National Key Research and Development Program of China (Grant No. 2017YFA0303002)the Natural Science Foundation of Shandong Province (Grant Nos. ZR2019MA036, and ZR2016AQ08)。
文摘We report the superconductivity of a new quaternary compound ThMo_(2)Si_(2)C, synthesized with the arc-melting technique. The compound crystallizes in a tetragonal CeCr_(2)Si_(2)C-type structure with cell parameters of a = 4.2296A and c = 5.3571 A. An interlayer Si–Si covalent bonding is suggested by the atomic distance. The electrical resistivity and magnetic susceptibility measurements indicate a Pauli-paramagnetic metal with dominant electron-electron scattering in the normal-state. Bulk superconductivity at 2.2 K is demonstrated with a dimensionless specific-heat jump of △C/γnT = 0.98. The superconducting parameters of the critical magnetic fields, coherence length, penetration depth, and superconducting energy gap are given.
基金National Natural Science Foundation of China,Grant/Award Number:51977118。
文摘In recent years,shutdown accidents caused by thyristor voltage monitoring(TVM)board failure have occurred several times in converter stations.With the increase of operation time,the working reliability problem of TVM board becomes a challenge to the safe operation.This paper studies the effects of pollution severity and relative humidity(RH)on the function of TVM board.The results show that the increase of RH can lead to the advance or even disappearance of check-back signals.Furthermore,the increase of pollution severity can decrease the failure RH threshold.Through simulation and equivalent experiment,it is verified that the resistance decrease of the voltage balancing resistor under the combined effect of contamination and RH is the main reason for the advance of check-back signals.According to the experiments,it is found that the upper surface contamination has a greater effect on the function of TVM board than the lower surface contamination,resulting in more decrease of the failure RH threshold.In addition,leakage current at different RH is also measured.Results show that the pulse peak of leakage current is closely related to check-back signals.When the pulse peak is too small or disappears,check-back signals also disappear,indicating that the TVM board fails.
