The composite of zeolitic imidazolate frameworks(ZIF-67)and ordered macroporous carbon(OMC)was successfully synthesized via in situ growth from the OMC matrix.The ZIF67–OMC composite was verified by scanning electron...The composite of zeolitic imidazolate frameworks(ZIF-67)and ordered macroporous carbon(OMC)was successfully synthesized via in situ growth from the OMC matrix.The ZIF67–OMC composite was verified by scanning electron microscopy(SEM)and transmission electron microscopy(TEM),powder X-ray diffraction(XRD)and electrochemical impedance spectroscopy(EIS)and then evaluated as a modified material for electrochemical sensor.Benefitting from the large surface area and enhanced conductivity of the ZIF67–OMC composite,ZIF67–OMC nanocomposite showed superior electrocatalytic performance toward acetaminophen(AP)oxidation.The redox reaction of AP underwent a quasi-reversible redox reaction with higher anodic current at ZIF67–OMC modified electrode compared with the bare glassy carbon electrode(GCE).In optimal condition,the ZIF67–OMC/GCE was stable,reproducible and had a linear range of 0.05–100 μmol·L^(-1) AP concentration,with the detection limit of 20 nmol·L^(-1)(signal-to-noise of S/N=3).In addition,the prepared sensing platform for the detection of AP was evaluated for the compound paracetamol tablets and urine samples.展开更多
Objective： This review aimed to provide a current recommendation to multidisciplinary physicians for early detection, diagnosis, and treatment of corticosteroid-induced osteonecrosis of the femoral head （ONFH） base...Objective： This review aimed to provide a current recommendation to multidisciplinary physicians for early detection, diagnosis, and treatment of corticosteroid-induced osteonecrosis of the femoral head （ONFH） based on a comprehensive analysis of the clinical literature. Data Sources： For the purpose of collecting potentially eligible articles, we searched for articles in the PubMed, Cochrane Library, Embase, and CNKI databases up to February 2017, using the following key words： ＆quot;corticosteroid＆quot;, ＆quot;osteonecrosis of the femoral head＆quot;,＆quot;risk factors＆quot;, ＆quot;diagnosis＆quot;, ＆quot;prognosis＆quot;, and ＆quot;treatment＆quot;. Study Selection： Articles on relationships between corticosteroid and ONFH were selected for this review. Articles on the diagnosis, prognosis, and intervention of earlier-stage ONFH were also reviewed. Results： The incidence of corticosteroid-induced ONFH was associated with high doses of corticosteroids, and underlying diseases in certain predisposed individuals mainly occurred in the first 3 months of corticosteroid prescription. The enhanced awareness and minimized exposure to the established risk factors and earlier definitive diagnosis are essential for the success of joint preservation. When following up patients with ONFH, treatment should be started if necessary. Surgical treatment yielded better results than conservative therapy in earlier-stage ONFH. The ideal purpose of earlier intervention and treatment is permanent preservation of the femoral head without physical restrictions in daily living. Conclusions： Clinicians should enhance their precaution awareness of corticosteroid-induced ONFH. For high-risk patients, regular follow-up is very important in the 1st year after high-dose prescription of corticosteroids. Patients with suspected ONFH should be referred to orthopedists for diagnosis and treatment in its earlier stage to preserve the joint.展开更多
To the Editor:Temporal depression is characterized by height difference between temporal concavity and lateral projection of the zygomatic arch.The aim of correction of temporal depression is to decrease the height di...To the Editor:Temporal depression is characterized by height difference between temporal concavity and lateral projection of the zygomatic arch.The aim of correction of temporal depression is to decrease the height difference between the concavity and lateral projection.In this study,we investigated whether decreasing the projection of the zygomatic arch by liposuction would benefit for correction of temporal depression.展开更多
Objective： To propose a new definition of the pericollapse stage of osteonecrosis of the femoral head （ONFH） and review its significance in disease diagnosis and treatment selection. Data Sources： A search for eli...Objective： To propose a new definition of the pericollapse stage of osteonecrosis of the femoral head （ONFH） and review its significance in disease diagnosis and treatment selection. Data Sources： A search for eligible studies was conducted in three electronic databases including PubMed, Cochrane Library, and Embase up to August 10, 2018, using the following keywords： ＂osteonecrosis＂, ＂prognosis＂, and ＂treatment＂. Study Selection： Investigations appraising the clinical signs, symptoms, and imaging manifestations in different stages of ONFH were included. Articles evaluating the prognosis of various joint-preserving procedures were also reviewed. Results： The pericollapse stage refers to a continuous period in the development of ONFH from the occurrence of subchondral fracture to early collapse （〈2 mm）, possessing specific imaging features that mainly consist of bone marrow edema and joint effusion on magnetic resonance imaging （MR1）, crescent signs on X-ray films, and clinical manifestations such as the sudden worsening of hip pain. Accumulating evidence has indicated that these findings may be secondary to the changes after subchondral fractures. Of note. computed tomography provides more information for identifying possible subchondral fractures than does MRI and serves as the most sensitive tool for grading the pericollapse lesion stage. The pericollapse stage may indicate a high possibility of progressive disease but also demonstrates satisfactory long- and medium-term outcomes fbr joint-preserving techniques. In tact, if the articular surface subsides more than 2 mm, total hip arthroplasty is preferable. Conclusions： The pericollapse stage with distinct clinical and imaging characteristics provides a last good opportunity for the use of joint-preserving techniques. It is necessary to separate the pericollapse stage as an independent state in evaluating the natural progression of ONFH and selecting an appropriate treatment regimen.展开更多
Background： The lateral pillar of the femoral head is an important site for disease development such as osteonecrosis of the femoral head. The femoral head consists of medial, central, and lateral pillars. This study...Background： The lateral pillar of the femoral head is an important site for disease development such as osteonecrosis of the femoral head. The femoral head consists of medial, central, and lateral pillars. This study aimed to determine the biomechanical effects of early osteonecrosis in pillars of the femoral head via a finite element （FE） analysis. Methods： A three-dimensional FE model of the intact hip joint was constructed from the image data of a healthy control. Further, a set of six early osteonecrosis models was developed based on the three-pillar classification. The von Mises stress and surface displacements were calculated for all models. Results： The peak values of von Mises stress in the cortical and cancellous bones of normal model were 6.41 MPa and 0.49 MPa, respectively. In models with necrotic lesions in the cortical and cancellous bones, the von Mises stress and displacement of lateral pillar showed significant variability： the stress of cortical bone decreased from 6.41 MPa to 1.51 MPa （76.0% reduction）, while cancellous bone showed an increase from 0.49 MPa to 1.28 MPa （159.0% increase）; surface displacements of cortical and cancellous bones increased from 52.4 μm and 52.1 μm to 67.9 μm （29.5%） and 61.9 μm （18.8%）, respectively. In addition, osteonecrosis affected not only pillars but also adjacent structures in terms of the von Mises stress and surface displacement levels. Conclusions： This study suggested that the early-stage necrosis in the femoral head could increase the risk of collapse, especially in lateral pillar. On the other hand, the cortical part of lateral pillar was found to be the main biomechanical support of femoral head.展开更多
Background：Systemic administration ofbisphosphonates has shown promising results in the treatment ofosteonecrosis of the femoral head （ONFH）.However,few studies have evaluated the efficacy of local zoledronate （ZO...Background：Systemic administration ofbisphosphonates has shown promising results in the treatment ofosteonecrosis of the femoral head （ONFH）.However,few studies have evaluated the efficacy of local zoledronate （ZOL） administration in the treatment of ONFH.The purpose of this study was to investigate whether local administration of bisphosphonate-soaked hydroxyapatite （HA） could improve bone healing in an experimental rabbit model of ONFH.Methods：This experimental study was conducted between October 2014 and June 2015.Forty-five rabbits underwent simulated ONFH surgery.Immediately following surgery,they were divided into three groups：model （untreated,n =15）,HA （treated with HA alone,n =15）,and HA ＋ ZOL （treated with HA soaked in a low-dose ZOL solution,n =15）.Histological,immunohistochemical,and quantitative analyses were performed to evaluate bone formation and resorption 2,4,and 8 weeks after surgery.Results：Gross bone matrix and hematopoietic tissue formation were observed in the HA ＋ ZOL group 4 weeks after surgery.The immunohistochemical staining intensities for 5-bromodeoxyuridine,runt-related transcription factor 2,osteocalcin,osteopontin,and osteoprotegerin were significantly higher in the HA ＋ ZOL group than that in the model （P 〈 0.001,P 〈 0.001,P 〈 0.001,P 〈 0.001,and P =0.018,respectively） and HA groups （P =0.003,P =0.049,P 〈 0.00l,P =0.020,and P =0.019,respectively）,whereas receptor activator of the nuclear factor-κB ligand staining intensity was significantly lower in the HA ＋ ZOL group than that in the model and HA groups （P =0.029 and P =0.015,respectively） 4 weeks after surgery.No significant differences in bone formation or bone resorption marker expression were found between the three groups 2 or 8 weeks after surgery （P 〉 0.05）.Conclusions：Local administration of HA soaked in a low-dose ZOL solution increased new bone formation while inhibiting bone resorption in an animal model of ONFH,which might provide new evidence for joint-preserving surgery in the treatment of ONFH.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.21904004 and 11804003)the Domestic Visiting Scholar Program for Outstanding Young Talents of Anhui Province(No.gxgnfx2019019)+2 种基金the Nature Foundation of Anhui Province(No.1808085MB31)the University Synergy Innovation Program of Anhui Province(Nos.GXXT-2019-043 and GXXT-2019-019)the Stable Talent Program and the Outstanding Talent Program of Anhui Science and Technology University。
文摘The composite of zeolitic imidazolate frameworks(ZIF-67)and ordered macroporous carbon(OMC)was successfully synthesized via in situ growth from the OMC matrix.The ZIF67–OMC composite was verified by scanning electron microscopy(SEM)and transmission electron microscopy(TEM),powder X-ray diffraction(XRD)and electrochemical impedance spectroscopy(EIS)and then evaluated as a modified material for electrochemical sensor.Benefitting from the large surface area and enhanced conductivity of the ZIF67–OMC composite,ZIF67–OMC nanocomposite showed superior electrocatalytic performance toward acetaminophen(AP)oxidation.The redox reaction of AP underwent a quasi-reversible redox reaction with higher anodic current at ZIF67–OMC modified electrode compared with the bare glassy carbon electrode(GCE).In optimal condition,the ZIF67–OMC/GCE was stable,reproducible and had a linear range of 0.05–100 μmol·L^(-1) AP concentration,with the detection limit of 20 nmol·L^(-1)(signal-to-noise of S/N=3).In addition,the prepared sensing platform for the detection of AP was evaluated for the compound paracetamol tablets and urine samples.
基金This study was supported by grants from the National Natura1 Science Foundation of China(No.81372013 and No.81672236)China-Japan Friendship Hospital Youth Science and Technology Excellence Proiect(No.2014-QNYC-A-06).
文摘Objective： This review aimed to provide a current recommendation to multidisciplinary physicians for early detection, diagnosis, and treatment of corticosteroid-induced osteonecrosis of the femoral head （ONFH） based on a comprehensive analysis of the clinical literature. Data Sources： For the purpose of collecting potentially eligible articles, we searched for articles in the PubMed, Cochrane Library, Embase, and CNKI databases up to February 2017, using the following key words： ＆quot;corticosteroid＆quot;, ＆quot;osteonecrosis of the femoral head＆quot;,＆quot;risk factors＆quot;, ＆quot;diagnosis＆quot;, ＆quot;prognosis＆quot;, and ＆quot;treatment＆quot;. Study Selection： Articles on relationships between corticosteroid and ONFH were selected for this review. Articles on the diagnosis, prognosis, and intervention of earlier-stage ONFH were also reviewed. Results： The incidence of corticosteroid-induced ONFH was associated with high doses of corticosteroids, and underlying diseases in certain predisposed individuals mainly occurred in the first 3 months of corticosteroid prescription. The enhanced awareness and minimized exposure to the established risk factors and earlier definitive diagnosis are essential for the success of joint preservation. When following up patients with ONFH, treatment should be started if necessary. Surgical treatment yielded better results than conservative therapy in earlier-stage ONFH. The ideal purpose of earlier intervention and treatment is permanent preservation of the femoral head without physical restrictions in daily living. Conclusions： Clinicians should enhance their precaution awareness of corticosteroid-induced ONFH. For high-risk patients, regular follow-up is very important in the 1st year after high-dose prescription of corticosteroids. Patients with suspected ONFH should be referred to orthopedists for diagnosis and treatment in its earlier stage to preserve the joint.
文摘To the Editor:Temporal depression is characterized by height difference between temporal concavity and lateral projection of the zygomatic arch.The aim of correction of temporal depression is to decrease the height difference between the concavity and lateral projection.In this study,we investigated whether decreasing the projection of the zygomatic arch by liposuction would benefit for correction of temporal depression.
文摘Objective： To propose a new definition of the pericollapse stage of osteonecrosis of the femoral head （ONFH） and review its significance in disease diagnosis and treatment selection. Data Sources： A search for eligible studies was conducted in three electronic databases including PubMed, Cochrane Library, and Embase up to August 10, 2018, using the following keywords： ＂osteonecrosis＂, ＂prognosis＂, and ＂treatment＂. Study Selection： Investigations appraising the clinical signs, symptoms, and imaging manifestations in different stages of ONFH were included. Articles evaluating the prognosis of various joint-preserving procedures were also reviewed. Results： The pericollapse stage refers to a continuous period in the development of ONFH from the occurrence of subchondral fracture to early collapse （〈2 mm）, possessing specific imaging features that mainly consist of bone marrow edema and joint effusion on magnetic resonance imaging （MR1）, crescent signs on X-ray films, and clinical manifestations such as the sudden worsening of hip pain. Accumulating evidence has indicated that these findings may be secondary to the changes after subchondral fractures. Of note. computed tomography provides more information for identifying possible subchondral fractures than does MRI and serves as the most sensitive tool for grading the pericollapse lesion stage. The pericollapse stage may indicate a high possibility of progressive disease but also demonstrates satisfactory long- and medium-term outcomes fbr joint-preserving techniques. In tact, if the articular surface subsides more than 2 mm, total hip arthroplasty is preferable. Conclusions： The pericollapse stage with distinct clinical and imaging characteristics provides a last good opportunity for the use of joint-preserving techniques. It is necessary to separate the pericollapse stage as an independent state in evaluating the natural progression of ONFH and selecting an appropriate treatment regimen.
基金This study was supported by grants from the National Natural Science Foundation of China(No.81673776)the Capital Health Research and Development of Special(No.2016-2-4062).
文摘Background： The lateral pillar of the femoral head is an important site for disease development such as osteonecrosis of the femoral head. The femoral head consists of medial, central, and lateral pillars. This study aimed to determine the biomechanical effects of early osteonecrosis in pillars of the femoral head via a finite element （FE） analysis. Methods： A three-dimensional FE model of the intact hip joint was constructed from the image data of a healthy control. Further, a set of six early osteonecrosis models was developed based on the three-pillar classification. The von Mises stress and surface displacements were calculated for all models. Results： The peak values of von Mises stress in the cortical and cancellous bones of normal model were 6.41 MPa and 0.49 MPa, respectively. In models with necrotic lesions in the cortical and cancellous bones, the von Mises stress and displacement of lateral pillar showed significant variability： the stress of cortical bone decreased from 6.41 MPa to 1.51 MPa （76.0% reduction）, while cancellous bone showed an increase from 0.49 MPa to 1.28 MPa （159.0% increase）; surface displacements of cortical and cancellous bones increased from 52.4 μm and 52.1 μm to 67.9 μm （29.5%） and 61.9 μm （18.8%）, respectively. In addition, osteonecrosis affected not only pillars but also adjacent structures in terms of the von Mises stress and surface displacement levels. Conclusions： This study suggested that the early-stage necrosis in the femoral head could increase the risk of collapse, especially in lateral pillar. On the other hand, the cortical part of lateral pillar was found to be the main biomechanical support of femoral head.
文摘Background：Systemic administration ofbisphosphonates has shown promising results in the treatment ofosteonecrosis of the femoral head （ONFH）.However,few studies have evaluated the efficacy of local zoledronate （ZOL） administration in the treatment of ONFH.The purpose of this study was to investigate whether local administration of bisphosphonate-soaked hydroxyapatite （HA） could improve bone healing in an experimental rabbit model of ONFH.Methods：This experimental study was conducted between October 2014 and June 2015.Forty-five rabbits underwent simulated ONFH surgery.Immediately following surgery,they were divided into three groups：model （untreated,n =15）,HA （treated with HA alone,n =15）,and HA ＋ ZOL （treated with HA soaked in a low-dose ZOL solution,n =15）.Histological,immunohistochemical,and quantitative analyses were performed to evaluate bone formation and resorption 2,4,and 8 weeks after surgery.Results：Gross bone matrix and hematopoietic tissue formation were observed in the HA ＋ ZOL group 4 weeks after surgery.The immunohistochemical staining intensities for 5-bromodeoxyuridine,runt-related transcription factor 2,osteocalcin,osteopontin,and osteoprotegerin were significantly higher in the HA ＋ ZOL group than that in the model （P 〈 0.001,P 〈 0.001,P 〈 0.001,P 〈 0.001,and P =0.018,respectively） and HA groups （P =0.003,P =0.049,P 〈 0.00l,P =0.020,and P =0.019,respectively）,whereas receptor activator of the nuclear factor-κB ligand staining intensity was significantly lower in the HA ＋ ZOL group than that in the model and HA groups （P =0.029 and P =0.015,respectively） 4 weeks after surgery.No significant differences in bone formation or bone resorption marker expression were found between the three groups 2 or 8 weeks after surgery （P 〉 0.05）.Conclusions：Local administration of HA soaked in a low-dose ZOL solution increased new bone formation while inhibiting bone resorption in an animal model of ONFH,which might provide new evidence for joint-preserving surgery in the treatment of ONFH.
