In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N‑isopropylacrylamide) and...In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N‑isopropylacrylamide) and MoS_(2). Under the action of an adjustable magnetic field, it can achieve steady motion at a frequency that allows it to move up to 35 mm/s, demonstrating high flexibility and controllability. It can also roll along a predetermined path, traverse mazes, climb over obstacles, among other functions. In addition, by harnessing the photothermal conversion effect of MoS_(2), the robot can be opened and closed using light, enabling controlled drug release. Targeted drug delivery is achieved in a gastric model using our designed soft robot, marking a significant clinical advancement expected to revolutionize future medical treatments and enhance the efficacy of drug therapy.展开更多
The design and manufacturing of microchannels are crucial aspects of modern micro/nanomanufacturing processes,offering a versatile platform for manipulating and driving micro/nanoparticles or cells.In this study,we pr...The design and manufacturing of microchannels are crucial aspects of modern micro/nanomanufacturing processes,offering a versatile platform for manipulating and driving micro/nanoparticles or cells.In this study,we propose a method for manufacturing microchannels using optically induced dielectrophoresis technology to induce the polymerization of polyethylene glycol diacrylate solution.To overcome limitations related to the light intensity energy and the size of intact microchannels,we design and manufacture microstructures of various shapes with a height of 4µm.Additionally,we simulate and analyze the movement of and forces acting on polystyrene(PS)microspheres at different spatial positions within the microchannels.Finally,we successfully demonstrate applications involving the transport of PS microspheres in custom-fabricated microchannels.This novel biocompatible microchannel manufacturing method is simple and non-biotoxic.It provides a new approach for simulating physiological environments in vitro and cultivating and manipulating cells.展开更多
Continuum robots,characterized by their simplicity,softness,and flexibility,hold significant promise for applications in the field of minimally invasive surgery.Nevertheless,the majority of existing continuum robots a...Continuum robots,characterized by their simplicity,softness,and flexibility,hold significant promise for applications in the field of minimally invasive surgery.Nevertheless,the majority of existing continuum robots are plagued by issues such as a single stiffness property and restricted operation space.To address these challenges,we have engineered a multistiffness nested cooperative magnetic continuum robot grounded in low melting point alloy(LMPA).The core components of this innovative robot are an orientator and a tracker.By integrating neodymium magnets within the orientator,the robot can effectively respond to the external magnetic field,thereby endowing it with a navigation capability.Furthermore,through precisely adjusting the phase and amplitude of the waveforms generated by the signal generator along the X,Y,and Z axes,the Helmholtz coils can produce programmable and controllable magnetic fields.This enables the robot to map out diverse paths,including the typical L-shaped,S-shaped,and U-shaped trajectories.Functionally,when equipped with a shape memory alloy(SMA)gripper,the robot can move steadily and precisely grasp objects within complex passages.This remarkable performance strongly attests to the robot's potential application value in industrial inspection,minimally invasive surgery,and other relevant fields.展开更多
基金the financial support through National Natural Science Foundation of China(Project No.62273289)The Youth Innovation Science and Technology Support Program of Shandong Province(Project No.2022KJ274)+1 种基金Shandong Provincial Natural Science Foundation(ZR2024MF007)Graduate Innovation Foundation of Yantai University,GIFYTU.
文摘In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N‑isopropylacrylamide) and MoS_(2). Under the action of an adjustable magnetic field, it can achieve steady motion at a frequency that allows it to move up to 35 mm/s, demonstrating high flexibility and controllability. It can also roll along a predetermined path, traverse mazes, climb over obstacles, among other functions. In addition, by harnessing the photothermal conversion effect of MoS_(2), the robot can be opened and closed using light, enabling controlled drug release. Targeted drug delivery is achieved in a gastric model using our designed soft robot, marking a significant clinical advancement expected to revolutionize future medical treatments and enhance the efficacy of drug therapy.
基金funded by the National Natural Science Foundation of China(Project No.62273289)The Youth Innovation Science and Technology Support Program of Shandong Province(Project No.2022KJ274)+1 种基金Natural Science Foundation of Shandong Province(Grant No.ZR2024MF007)Graduate Innovation Foundation of Yantai University,GIFYTU.
文摘The design and manufacturing of microchannels are crucial aspects of modern micro/nanomanufacturing processes,offering a versatile platform for manipulating and driving micro/nanoparticles or cells.In this study,we propose a method for manufacturing microchannels using optically induced dielectrophoresis technology to induce the polymerization of polyethylene glycol diacrylate solution.To overcome limitations related to the light intensity energy and the size of intact microchannels,we design and manufacture microstructures of various shapes with a height of 4µm.Additionally,we simulate and analyze the movement of and forces acting on polystyrene(PS)microspheres at different spatial positions within the microchannels.Finally,we successfully demonstrate applications involving the transport of PS microspheres in custom-fabricated microchannels.This novel biocompatible microchannel manufacturing method is simple and non-biotoxic.It provides a new approach for simulating physiological environments in vitro and cultivating and manipulating cells.
基金supported by the National Key R&D Program of China(Grant No.2024YFB4707300)the National Natural Science Foundation of China(Grant No.62273289)+3 种基金the Youth Innovation Science and Technology Support Program of Shandong Province(Grant No.2022KJ274)the Shandong Provincial Natural Science Foundation(Grant No.ZR2024MF007)the Fundamental Research Projects of Science&Technology Innovation and Development Plan in Yantai City(Grant No.2024JCYJ050)the Graduate Innovation Foundation of Yantai University。
文摘Continuum robots,characterized by their simplicity,softness,and flexibility,hold significant promise for applications in the field of minimally invasive surgery.Nevertheless,the majority of existing continuum robots are plagued by issues such as a single stiffness property and restricted operation space.To address these challenges,we have engineered a multistiffness nested cooperative magnetic continuum robot grounded in low melting point alloy(LMPA).The core components of this innovative robot are an orientator and a tracker.By integrating neodymium magnets within the orientator,the robot can effectively respond to the external magnetic field,thereby endowing it with a navigation capability.Furthermore,through precisely adjusting the phase and amplitude of the waveforms generated by the signal generator along the X,Y,and Z axes,the Helmholtz coils can produce programmable and controllable magnetic fields.This enables the robot to map out diverse paths,including the typical L-shaped,S-shaped,and U-shaped trajectories.Functionally,when equipped with a shape memory alloy(SMA)gripper,the robot can move steadily and precisely grasp objects within complex passages.This remarkable performance strongly attests to the robot's potential application value in industrial inspection,minimally invasive surgery,and other relevant fields.
