Hepatitis B virus(HBV)establishes chronic infection through strategic manipulation of host metabolic networks,driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular carcinoma....Hepatitis B virus(HBV)establishes chronic infection through strategic manipulation of host metabolic networks,driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular carcinoma.Mechanistically,HBV reprograms core metabolic pathways,including glycolysis,tricarboxylic acid(TCA)cycle,oxidative phosphorylation,and lipid homeostasis,to fuel its replication machinery and evade immune surveillance.This review systematically synthesizes current evidence on HBV-induced glucose/lipid metabolic rewiring,with particular emphasis on how viral-host crosstalk at the metabolic interface sustains viral pathogenesis.展开更多
The Yellow River(YR),China’s second-longest river,remains understudied regarding its greenhouse gases(GHGs)emissions,particularly the impacts of urban drainage ditches and wastewater treatment facilities on regional ...The Yellow River(YR),China’s second-longest river,remains understudied regarding its greenhouse gases(GHGs)emissions,particularly the impacts of urban drainage ditches and wastewater treatment facilities on regional GHGs dynamics.This study investigated methane(CH_(4))and carbon dioxide(CO_(2))concentrations,fluxes and stable carbon isotopes(δ^(13)C-CH_(4)and δ^(13)C-CO_(2))across six main stream,three ditches,and one wastewater treatment site along the upper Lanzhou section of the YR,spanning from the urban entrance(36.176°N,103.449°E)to the exit of Lanzhou city(36.056°N,104.020°E).Measured CH_(4)diffusion fluxes in mainstem sites ranged from 0.01 to 2.58 mmol·m^(−2)·d^(−1)(mean:0.36 mmol·m^(−2)·d^(−1)),while ebullitive fluxes(gas bubbles)ranged from 0.01 to 18.89 mmol·m^(−2)·d^(−1)(mean:0.90 mmol·m^(−2)·d^(−1)).CO_(2)diffusion fluxes varied between 9.16–92.80 mmol·m^(−2)·d^(−1)(averaged:39.11 mmol·m^(−2)·d^(−1))at these locations.Ebullition(bubble)fluxes accounted for 53.1%±22.4%(range:9.0%to 98.4%)to total CH_(4)emissions(diffusion plus ebullition),with peak fluxes occurring during summer,indicating its significance as a CH_(4)transport mechanism.Notably,both diffusion CH_(4)and CO_(2)fluxes and ebullitive CH_(4)rates at ditch sites substantially exceeded those in mainstream reaches.The lowest CH_(4)and highest CO_(2)concentrations were observed at a wastewater treatment site,likely resulting from the removal of high organic loads.Acetoclastic methanogenesis—the process converting acetate-derived methyl groups to CH_(4)—was identified as the dominant production pathway in both mainstream and ditch environments.CH_(4)and CO_(2)flux magnitudes in the upper YR(Lanzhou section)were comparable to those observed in subtropical Yangtze River tributaries.These results demonstrate that anthropogenic influences significantly enhance CO_(2)/CH_(4)emissions,and the lateral exports of dissolved carbon(DIC and DOC)in the main stream site was quantified.,which cannot be overlooked.The findings emphasize the critical need to account for pronounced spatiotemporal variations in arid-region GHG fluxes to improve basin-scale estimates for the YR.展开更多
Pollutants contained in wastewater pose serious harm to the environment.Graphene-based water treatment materials show significant advantages in wastewater treatment.However,with the development of graphene-based mater...Pollutants contained in wastewater pose serious harm to the environment.Graphene-based water treatment materials show significant advantages in wastewater treatment.However,with the development of graphene-based materials,its progress in water treatment has reached a bottleneck.The challenge lies in effectively enhancing its performance in water treatment and ensuring its practicality.By employing biomimetic approaches,some exceptional properties and structures found in nature can be mimicked in graphene materials,effectively enhancing graphene's adsorption and mechanical properties.Current biomimetic methods include biomimetic mineralization,self-assembly,and templating.unfortunately,all of the above methods suffer from the disadvantages of complexity and poor bionic effect.Nevertheless,3D printing,a form of additive manufacturing(AM)technology,offers integrated molding and excellent biomimetic performance in creating biomimetic materials.This paper will cover the following aspects:(1)An overview of objects suitable for bionics in terms of functional and structural aspects,along with their properties,and a discussion of various bionic objects combined with graphene materials in water treatment and related research;(2)a comparison of different methods for preparing graphene-based bionic materials;(3)an examination of the current drawbacks and limitations of graphene-based biomimetic materials;and(4)a conclusion and future prospects,exploring the potential of using 3D printing technology to produce graphene biomimetic materials.This review aims to serve as a guide for effectively leveraging natural inspirations to create graphene-based biomimetic materials and enhance graphene properties.展开更多
The reasonable design of material morphology and eco-friendly electrocatalysts are essential to highly efficient water splitting.It is proposed that a promising strategy effectively regulates the electronic structure ...The reasonable design of material morphology and eco-friendly electrocatalysts are essential to highly efficient water splitting.It is proposed that a promising strategy effectively regulates the electronic structure of the d-orbitals of CoP using cerium doping in this paper,thus significantly improving the intrinsic property and conductivity of CoP for water splitting.As a result,the as-synthesize porous Ce-doped CoP micro-polyhedron composite derived from Ce-ZIF-67 as bifunctional electrocatalytic materials exhibits excellent electrocatalytic performance in both the oxygen evolution reaction(OER)and the hydrogen evolution reaction(HER),overpotentials of about 152 mV for HER at 10 mA cm^(-2)and about 352 mV for OER at 50 mA cm^(-2),and especially it shows outstanding long-term stability.Besides,an alkaline electrolyzer,using Ce0.04Co0.96P electrocatalyst as both the anode and cathode,delivers a cell voltage value of1.55 V at the current density of 10 mA cm^(-2).The calculation results of the density functional theory(DFT)demonstrate that the introduction of an appropriate amount of Ce into CoP can enhance the conductivity,and can induce the electronic modulation to regulate the selective adsorption of reaction intermediates on catalytic surface and the formation of O*intermediates(CoOOH),which exhibits an excellent electrocatalytic performance.This study provides novel insights into the design of an extraordinary performance water-splitting of the multicomponent electrocatalysts.展开更多
With the continuous growth of air traffic flow, some airports in China or other countries begin to construct Closely Spaced Parallel Runways(CSPR) to meet the capacity requirement of civil aviation. In this paper, the...With the continuous growth of air traffic flow, some airports in China or other countries begin to construct Closely Spaced Parallel Runways(CSPR) to meet the capacity requirement of civil aviation. In this paper, the simulation and calculation method of flight trajectory is developed,as well as the collision risk calculation method and wake vortex encounter risk calculation method.New methods for departure and go-around procedures are proposed to achieve approximate segregated parallel operation in an attempt to obtain approximately the same results on closely spaced parallel runways as on widely spaced parallel runways. By comparing with the independent parallel departure and segregated parallel operation in ICAO Doc. 9643, it is found that the lateral separation between aircraft in this proposal is not less than the separations in the other two cases. Based on the simulation calculation of flight trajectories under different conditions, the probabilities of collision conflict and encountering wake vortex are lower than those in current operation plan.The proposed plan has no special requirements in pilot operation, control command procedures,airport facilities, or meteorological observation and prediction, so it is convenient to promote and implement at the airports with closely spaced parallel runways.展开更多
In the 6G era,Space-Air-Ground Integrated Network(SAGIN)are anticipated to deliver global coverage,necessitating support for a diverse array of emerging applications in high-mobility,hostile environments.Under such co...In the 6G era,Space-Air-Ground Integrated Network(SAGIN)are anticipated to deliver global coverage,necessitating support for a diverse array of emerging applications in high-mobility,hostile environments.Under such conditions,conventional orthogonal frequency division multiplexing(OFDM)modulation,widely employed in cellular and Wi-Fi communication systems,experiences performance degradation due to significant Doppler shifts.To overcome this obstacle,a novel twodimensional(2D)modulation approach,namely orthogonal time frequency space(OTFS),has emerged as a key enabler for future high-mobility use cases.Distinctively,OTFS modulates information within the delay-Doppler(DD)domain,as opposed to the timefrequency(TF)domain utilized by OFDM.This offers advantages such as Doppler and delay resilience,reduced signaling latency,a lower peak-to-average ratio(PAPR),and a reduced-complexity implementation.Recent studies further indicate that the direct interplay between information and the physical world in the DD domain positions OTFS as a promising waveform for achieving integrated sensing and communications(ISAC).In this article,we present an in-depth review of OTFS technology in the context of the 6G era,encompassing fundamentals,recent advancements,and future directions.Our objective is to provide a helpful resource for researchers engaged in the field of OTFS.展开更多
Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses...Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions.展开更多
Mammalian target of rapamycin(m TOR) is a conserved Ser/Thr kinase that includes m TOR complex(m TORC) 1 and m TORC2. The m TOR pathway is activated in viral hepatitis, including hepatitis B virus(HBV) infection-induc...Mammalian target of rapamycin(m TOR) is a conserved Ser/Thr kinase that includes m TOR complex(m TORC) 1 and m TORC2. The m TOR pathway is activated in viral hepatitis, including hepatitis B virus(HBV) infection-induced hepatitis.Currently, chronic HBV infection remains one of the most serious public health issues worldwide. The unavailability of effective therapeutic strategies for HBV suggests that clarification of the pathogenesis of HBV infection is urgently required. Increasing evidence has shown that HBV infection can activate the m TOR pathway, indicating that HBV utilizes or hijacks the m TOR pathway to benefit its own replication. Therefore, the m TOR signaling pathway might be a crucial target for controlling HBV infection. Here, we summarize and discuss the latest findings from model biology research regarding the interaction between the m TOR signaling pathway and HBV replication.展开更多
Oxygen reduction reaction(ORR) plays a critical role in many energy conversion and storage processes.Therein, a comparative study of the electrocatalytic activity for ORR in 0.1 mol/L KOH solution was conducted using ...Oxygen reduction reaction(ORR) plays a critical role in many energy conversion and storage processes.Therein, a comparative study of the electrocatalytic activity for ORR in 0.1 mol/L KOH solution was conducted using layered perovskite-like LaSr_3 Fe_3 O_(10) and LaSr3 Fe_3 O_(10)-graphene oxide(GO) composite as electrodes. Linear sweep voltammetry(LSV) results show that the LaSr3 Fe_3 O_(10)-GO hybrid exhibits higher current density, a more positive onset potential(-0.15 V vs. Hg/HgO) in comparison with LaSr_3 Fe_3 O_(10).The value of the overall transferred electrons for both catalysts implies a dominant two electron process for ORR. Both catalysts under alkalic conditions exhibit a two-step Tafel slope, suggesting a change in the reaction mechanism for ORR. The composite electrode exhibits a higher ORR current density, but inferior durability performances in relative to the LaSr_3 Fe_3 O_(10) electrode.展开更多
Aircraft wake turbulence is an inherent outcome of aircraft flight,presenting a substan-tial challenge to air traffic control,aviation safety and operational efficiency.Building upon data obtained from coherent Dopple...Aircraft wake turbulence is an inherent outcome of aircraft flight,presenting a substan-tial challenge to air traffic control,aviation safety and operational efficiency.Building upon data obtained from coherent Doppler Lidar detection,and combining Dynamic Bayesian Networks(DBN)with Genetic Algorithm-optimized Backpropagation Neural Networks(GA-BPNN),this paper proposes a model for the inversion of wake vortex parameters.During the wake vortex flow field simulation analysis,the wind and turbulent environment were initially superimposed onto the simulated wake velocity field.Subsequently,Lidar-detected echoes of the velocity field are simulated to obtain a data set similar to the actual situation for model training.In the case study validation,real measured data underwent preprocessing and were then input into the established model.This allowed us to construct the wake vortex characteristic parameter inversion model.The final results demonstrated that our model achieved parameter inversion with only minor errors.In a practical example,our model in this paper significantly reduced the mean square error of the inverted velocity field when compared to the traditional algorithm.This study holds significant promise for real-time monitoring of wake vortices at airports,and is proved a crucial step in developing wake vortex interval standards.展开更多
Chinese milk vetch （Astragalus sinicus L. ） is a conunonly used green manure crop in paddy fields in southern China and it has the effect of fostering fertility and soil. This paper firstly sununarized advances in r...Chinese milk vetch （Astragalus sinicus L. ） is a conunonly used green manure crop in paddy fields in southern China and it has the effect of fostering fertility and soil. This paper firstly sununarized advances in research of new high quality and yield varieties of germplasm resources of Chinese milk vetch. Then, on the basis of current situation, it came up with recommendations for collection, storage and promotion, as well as application in the current ecological agriculture, including establishing germplasm resource bank and improving germplasm resource evaluation system.展开更多
Although the electrospinning technique has been devoted to promoting therapeutic purposes as a drug carrier,however,there are still many fundamental problems in this area.This work focuses on a comparison of various d...Although the electrospinning technique has been devoted to promoting therapeutic purposes as a drug carrier,however,there are still many fundamental problems in this area.This work focuses on a comparison of various diameter polyethersulfone(PES)electrospun ultrafine fibers as an-timicrobial materials.The fibrous morphology,antimicrobial agent distribution,thermally property,and biocompatibility evaluation of PES-based ultrafine fibers were systematically in-vestigated.The results demonstrated that the PES-based ultrafine fibers were suitable as anti-microbial material.Furthermore,the drug release behavior and mechanism were studied through total immersion.The release mechanism was confirmed to Fickian diffusion.It was revealed that the drug max release amount(71.5%)and release rate(7.71)are the highest for the smallest diameter ultrafine fibers.Meanwhile,the antimicrobial activity of PES ultrafine fibers is also inversely correlated with the diameter of fiber.The electrospun PES fibers would control their release behavior through the diameter and have a potential application in the wound dressings,such as chronic osteomyelitis and exposure injury.展开更多
LaSr2 Mn2 O7,a Ruddlesden-Popper type bilayered perovskite,was investigated as oxygen catalyst for oxygen reduction reaction(ORR) and active electrode material for electrochemical capacitors in KOH solutions.XPS resul...LaSr2 Mn2 O7,a Ruddlesden-Popper type bilayered perovskite,was investigated as oxygen catalyst for oxygen reduction reaction(ORR) and active electrode material for electrochemical capacitors in KOH solutions.XPS results show that Mn takes a mixed Mn2+,Mn3+and Mn4+valence state with an average valence of 3.4.As catalyst towards ORR,LaSr2 Mn2 O7 and LaSr2 Mn2 O7/acetylene black composite favor four electron pathways for ORR.LaSr2 Mn2 O7/C composite shows a comparable onset potential for ORR to that of Pt/C electrode.The improved ORR activity of LaSr2 Mn2 O7/acetylene black composite is attributed to the synergy between catalytic LaSr2 Mn2 O7 and conductive acetylene black.As electrode material for electrochemical capacitors,LaSr2 Mn2 O7 exhibits a maximum specific capacitance of 167.2 F/g with 62%faradic contribution at a scan rate of 1 mV/s in cyclic voltammetry test.展开更多
A regional coupled prediction system for the Asia-Pacific(AP-RCP)(38°E-180°,20°S-60°N) area has been established.The AP-RCP system consists of WRF-ROMS(Weather Research and Forecast,and Regional Oc...A regional coupled prediction system for the Asia-Pacific(AP-RCP)(38°E-180°,20°S-60°N) area has been established.The AP-RCP system consists of WRF-ROMS(Weather Research and Forecast,and Regional Ocean Model System) coupled models combined with local observational information through dynamically downscaling coupled data assimilation(CDA).The system generates 18-day forecasts for the atmosphere and ocean environment on a daily quasi-operational schedule at Pilot National Laboratory for Marine Science and Technology(Qingdao)(QNLM),consisting of 2 different-resolution coupled models:27 km WRF coupled with 9 km ROMS,9 km WRF coupled with 3 km ROMS,while a version of 3 km WRF coupled with 3 km ROMS is in a test mode.This study is a first step to evaluate the impact of high-resolution coupled model with dynamically downscaling CDA on the extended-range predictions,focusing on forecasts of typhoon onset,improved precipitation and typhoon intensity forecasts as well as simulation of the Kuroshio current variability associated with mesoscale oceanic activities.The results show that for realizing the extended-range predictability of atmospheric and oceanic environment characterized by statistics of mesoscale activities,a fine resolution coupled model resolving local mesoscale phenomena with balanced and coherent coupled initialization is a necessary first step.The next challenges include improving the planetary boundary physics and the representation of air-sea and air-land interactions to enable the model to resolve kilometer or sub-kilometer processes.展开更多
1 Introduction Key-value data,as NoSQL data widely used in recent years,has been frequently collected and used for analysis in major websites and mobile apps.The frequency distribution estimation on the key domain,as ...1 Introduction Key-value data,as NoSQL data widely used in recent years,has been frequently collected and used for analysis in major websites and mobile apps.The frequency distribution estimation on the key domain,as well as the mean estimation of values associated with the same key,are crucial and worth billion dollars in the business.However,in real applications,the key-value records are submitted by terminal devices of different users.Directly collecting the information from users may pose serious risks on personal privacy.On the other hand,the emerging shuffled differential privacy(SDP)model[1]is proposed to collect sensitive data from users.展开更多
To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natura...To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball method.The tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal stability.The stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were investigated.The results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.展开更多
Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical practice.Unfortunately,current pharmacological treatments for neuropathic pain lack clinical effic...Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical practice.Unfortunately,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse reactions.As G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining momentum.Extensive research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse effects.This review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this treatment.We will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased agonists.It is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.展开更多
Virtual marine scene authoring plays an important role in generating large-scale 3D scenes and it has a wide range of applications in computer animation and simulation.Existing marine scene authoring methods either pr...Virtual marine scene authoring plays an important role in generating large-scale 3D scenes and it has a wide range of applications in computer animation and simulation.Existing marine scene authoring methods either produce periodic patterns or generate unnatural group distributions when tiling marine entities such as schools of fish and groups of reefs.To this end,we propose a new large-scale marine scene authoring method based on real examples in order to create more natural and realistic results.Our method first extracts the distribution of multiple marine entities from real images to create Octahedral Blocks,and then we use a modified Wang Cubes algorithm to quickly tile the 3D marine scene.As a result,our method is able to generate aperiodic tiling results with diverse distributions of density and orientation of entities.We validate the effectiveness of our method through intensive comparative experiments.User study results show that our method can generate satisfactory results which are in accord with human preferences.展开更多
The divergent reductive cross-coupling with an ambident electrophile is rare.Previously,we demonstrated a nickel-catalyzed reductive 2-pyridination of aryl iodides with difluoromethyl 2-pyridyl sulfone(2-Py SO_(2)CF_(...The divergent reductive cross-coupling with an ambident electrophile is rare.Previously,we demonstrated a nickel-catalyzed reductive 2-pyridination of aryl iodides with difluoromethyl 2-pyridyl sulfone(2-Py SO_(2)CF_(2)H)via selective C(sp^(2))-S bond cleavage of the sulfone by using a phosphine ligand.In this communication,we report a novel nickel-catalyzed reductive coupling of aryl iodides and 2-Py SO_(2)CF_(2)H reagent,which constitutes a new method for aromatic difluoromethylation.The use of a tridentate terpyridine ligand is pivotal for the selective C(sp^(3))-S bond cleavage of the sulfone.This method employs readily available nickel catalyst and 2-Py SO_(2)CF_(2)H as the difluoromethylation reagent,providing a facile access to difluoromethylarenes under mild reaction conditions without pre-generation of arylmetal reagents.展开更多
基金supported by the National Natural Science Foundation of China(82202497)the National Key R&D Program of China(2023YFC2306800)the Fundamental Research Funds for the Central Universities(226-2024-00129).
文摘Hepatitis B virus(HBV)establishes chronic infection through strategic manipulation of host metabolic networks,driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular carcinoma.Mechanistically,HBV reprograms core metabolic pathways,including glycolysis,tricarboxylic acid(TCA)cycle,oxidative phosphorylation,and lipid homeostasis,to fuel its replication machinery and evade immune surveillance.This review systematically synthesizes current evidence on HBV-induced glucose/lipid metabolic rewiring,with particular emphasis on how viral-host crosstalk at the metabolic interface sustains viral pathogenesis.
基金funded by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0950000)the NSFC(Grant No.42201155+2 种基金4240114742201137)the State Key Laboratory of Cryospheric Science and Frozen Soil Engineering(CSFSE-ZQ-2410).
文摘The Yellow River(YR),China’s second-longest river,remains understudied regarding its greenhouse gases(GHGs)emissions,particularly the impacts of urban drainage ditches and wastewater treatment facilities on regional GHGs dynamics.This study investigated methane(CH_(4))and carbon dioxide(CO_(2))concentrations,fluxes and stable carbon isotopes(δ^(13)C-CH_(4)and δ^(13)C-CO_(2))across six main stream,three ditches,and one wastewater treatment site along the upper Lanzhou section of the YR,spanning from the urban entrance(36.176°N,103.449°E)to the exit of Lanzhou city(36.056°N,104.020°E).Measured CH_(4)diffusion fluxes in mainstem sites ranged from 0.01 to 2.58 mmol·m^(−2)·d^(−1)(mean:0.36 mmol·m^(−2)·d^(−1)),while ebullitive fluxes(gas bubbles)ranged from 0.01 to 18.89 mmol·m^(−2)·d^(−1)(mean:0.90 mmol·m^(−2)·d^(−1)).CO_(2)diffusion fluxes varied between 9.16–92.80 mmol·m^(−2)·d^(−1)(averaged:39.11 mmol·m^(−2)·d^(−1))at these locations.Ebullition(bubble)fluxes accounted for 53.1%±22.4%(range:9.0%to 98.4%)to total CH_(4)emissions(diffusion plus ebullition),with peak fluxes occurring during summer,indicating its significance as a CH_(4)transport mechanism.Notably,both diffusion CH_(4)and CO_(2)fluxes and ebullitive CH_(4)rates at ditch sites substantially exceeded those in mainstream reaches.The lowest CH_(4)and highest CO_(2)concentrations were observed at a wastewater treatment site,likely resulting from the removal of high organic loads.Acetoclastic methanogenesis—the process converting acetate-derived methyl groups to CH_(4)—was identified as the dominant production pathway in both mainstream and ditch environments.CH_(4)and CO_(2)flux magnitudes in the upper YR(Lanzhou section)were comparable to those observed in subtropical Yangtze River tributaries.These results demonstrate that anthropogenic influences significantly enhance CO_(2)/CH_(4)emissions,and the lateral exports of dissolved carbon(DIC and DOC)in the main stream site was quantified.,which cannot be overlooked.The findings emphasize the critical need to account for pronounced spatiotemporal variations in arid-region GHG fluxes to improve basin-scale estimates for the YR.
基金supported by the National Natural Science Foundation of China(No.52060015)China Postdoctoral Science Foundation(No.2019M653796)+2 种基金Natural Science Foundation of Gansu Province(No.20JR10RA197)Science and Technology Innovation Fund of Gansu Academy of Sciences(No.2019QN-08)the“Hongliu Excellent Young Talents Support Program”of the Lanzhou University of Technology。
文摘Pollutants contained in wastewater pose serious harm to the environment.Graphene-based water treatment materials show significant advantages in wastewater treatment.However,with the development of graphene-based materials,its progress in water treatment has reached a bottleneck.The challenge lies in effectively enhancing its performance in water treatment and ensuring its practicality.By employing biomimetic approaches,some exceptional properties and structures found in nature can be mimicked in graphene materials,effectively enhancing graphene's adsorption and mechanical properties.Current biomimetic methods include biomimetic mineralization,self-assembly,and templating.unfortunately,all of the above methods suffer from the disadvantages of complexity and poor bionic effect.Nevertheless,3D printing,a form of additive manufacturing(AM)technology,offers integrated molding and excellent biomimetic performance in creating biomimetic materials.This paper will cover the following aspects:(1)An overview of objects suitable for bionics in terms of functional and structural aspects,along with their properties,and a discussion of various bionic objects combined with graphene materials in water treatment and related research;(2)a comparison of different methods for preparing graphene-based bionic materials;(3)an examination of the current drawbacks and limitations of graphene-based biomimetic materials;and(4)a conclusion and future prospects,exploring the potential of using 3D printing technology to produce graphene biomimetic materials.This review aims to serve as a guide for effectively leveraging natural inspirations to create graphene-based biomimetic materials and enhance graphene properties.
基金supported by the National Natural Science Foundation of China(No.12162023&52268042)Key R&D Program of Gansu Province-International Cooperation Project(No.20YF8WA064)Natural Science Foundation of Gansu Province(No.22JR5RA253).
文摘The reasonable design of material morphology and eco-friendly electrocatalysts are essential to highly efficient water splitting.It is proposed that a promising strategy effectively regulates the electronic structure of the d-orbitals of CoP using cerium doping in this paper,thus significantly improving the intrinsic property and conductivity of CoP for water splitting.As a result,the as-synthesize porous Ce-doped CoP micro-polyhedron composite derived from Ce-ZIF-67 as bifunctional electrocatalytic materials exhibits excellent electrocatalytic performance in both the oxygen evolution reaction(OER)and the hydrogen evolution reaction(HER),overpotentials of about 152 mV for HER at 10 mA cm^(-2)and about 352 mV for OER at 50 mA cm^(-2),and especially it shows outstanding long-term stability.Besides,an alkaline electrolyzer,using Ce0.04Co0.96P electrocatalyst as both the anode and cathode,delivers a cell voltage value of1.55 V at the current density of 10 mA cm^(-2).The calculation results of the density functional theory(DFT)demonstrate that the introduction of an appropriate amount of Ce into CoP can enhance the conductivity,and can induce the electronic modulation to regulate the selective adsorption of reaction intermediates on catalytic surface and the formation of O*intermediates(CoOOH),which exhibits an excellent electrocatalytic performance.This study provides novel insights into the design of an extraordinary performance water-splitting of the multicomponent electrocatalysts.
基金funded by the National Natural Science Foundation of China (Nos. U1533116, U1633125)Project Foundation of Civil Aircraft for MIIT of China (No. MJ-2016-Y76)the Fundamental Research Funds for the Central Universities of CAUC of China (No. 3122017067)
文摘With the continuous growth of air traffic flow, some airports in China or other countries begin to construct Closely Spaced Parallel Runways(CSPR) to meet the capacity requirement of civil aviation. In this paper, the simulation and calculation method of flight trajectory is developed,as well as the collision risk calculation method and wake vortex encounter risk calculation method.New methods for departure and go-around procedures are proposed to achieve approximate segregated parallel operation in an attempt to obtain approximately the same results on closely spaced parallel runways as on widely spaced parallel runways. By comparing with the independent parallel departure and segregated parallel operation in ICAO Doc. 9643, it is found that the lateral separation between aircraft in this proposal is not less than the separations in the other two cases. Based on the simulation calculation of flight trajectories under different conditions, the probabilities of collision conflict and encountering wake vortex are lower than those in current operation plan.The proposed plan has no special requirements in pilot operation, control command procedures,airport facilities, or meteorological observation and prediction, so it is convenient to promote and implement at the airports with closely spaced parallel runways.
基金supported in part by National Natural Science Foundation of China under Grant 62101232in part by Guangdong Provincial Natural Science Foundation under Grant 2022A1515011257in part by Shenzhen Science and Technology Program under Grant JCYJ20220530114412029。
文摘In the 6G era,Space-Air-Ground Integrated Network(SAGIN)are anticipated to deliver global coverage,necessitating support for a diverse array of emerging applications in high-mobility,hostile environments.Under such conditions,conventional orthogonal frequency division multiplexing(OFDM)modulation,widely employed in cellular and Wi-Fi communication systems,experiences performance degradation due to significant Doppler shifts.To overcome this obstacle,a novel twodimensional(2D)modulation approach,namely orthogonal time frequency space(OTFS),has emerged as a key enabler for future high-mobility use cases.Distinctively,OTFS modulates information within the delay-Doppler(DD)domain,as opposed to the timefrequency(TF)domain utilized by OFDM.This offers advantages such as Doppler and delay resilience,reduced signaling latency,a lower peak-to-average ratio(PAPR),and a reduced-complexity implementation.Recent studies further indicate that the direct interplay between information and the physical world in the DD domain positions OTFS as a promising waveform for achieving integrated sensing and communications(ISAC).In this article,we present an in-depth review of OTFS technology in the context of the 6G era,encompassing fundamentals,recent advancements,and future directions.Our objective is to provide a helpful resource for researchers engaged in the field of OTFS.
基金supported by the National Key Research&Development Program of China(Grant Nos.2017YFC1404100 and 2017YFC1404104)the National Natural Science Foundation of China(Grant Nos.41775100 and 41830964)。
文摘Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions.
基金This work was supported by a scholarship from the Medical Faculty of University Duisburg-Essenthe Foundation for Innovative Research Groups of Hubei Provincial Natural Science Foundation(2018CFA031)+1 种基金Hubei Province’s Outstanding Medical Academic Leader Program,the National Natural Science Foundation of China(No.81974079)the Key R&D Program of Hunan province(No.2020SK30291)。
文摘Mammalian target of rapamycin(m TOR) is a conserved Ser/Thr kinase that includes m TOR complex(m TORC) 1 and m TORC2. The m TOR pathway is activated in viral hepatitis, including hepatitis B virus(HBV) infection-induced hepatitis.Currently, chronic HBV infection remains one of the most serious public health issues worldwide. The unavailability of effective therapeutic strategies for HBV suggests that clarification of the pathogenesis of HBV infection is urgently required. Increasing evidence has shown that HBV infection can activate the m TOR pathway, indicating that HBV utilizes or hijacks the m TOR pathway to benefit its own replication. Therefore, the m TOR signaling pathway might be a crucial target for controlling HBV infection. Here, we summarize and discuss the latest findings from model biology research regarding the interaction between the m TOR signaling pathway and HBV replication.
基金Project supported by National Natural Science Foundation of China(21571095,61366004)Science and Technology Program of Jiangxi Education Department,China(GJJ14535)
文摘Oxygen reduction reaction(ORR) plays a critical role in many energy conversion and storage processes.Therein, a comparative study of the electrocatalytic activity for ORR in 0.1 mol/L KOH solution was conducted using layered perovskite-like LaSr_3 Fe_3 O_(10) and LaSr3 Fe_3 O_(10)-graphene oxide(GO) composite as electrodes. Linear sweep voltammetry(LSV) results show that the LaSr3 Fe_3 O_(10)-GO hybrid exhibits higher current density, a more positive onset potential(-0.15 V vs. Hg/HgO) in comparison with LaSr_3 Fe_3 O_(10).The value of the overall transferred electrons for both catalysts implies a dominant two electron process for ORR. Both catalysts under alkalic conditions exhibit a two-step Tafel slope, suggesting a change in the reaction mechanism for ORR. The composite electrode exhibits a higher ORR current density, but inferior durability performances in relative to the LaSr_3 Fe_3 O_(10) electrode.
基金supported by the National Natural Science Foundation of China (No.U2133210).
文摘Aircraft wake turbulence is an inherent outcome of aircraft flight,presenting a substan-tial challenge to air traffic control,aviation safety and operational efficiency.Building upon data obtained from coherent Doppler Lidar detection,and combining Dynamic Bayesian Networks(DBN)with Genetic Algorithm-optimized Backpropagation Neural Networks(GA-BPNN),this paper proposes a model for the inversion of wake vortex parameters.During the wake vortex flow field simulation analysis,the wind and turbulent environment were initially superimposed onto the simulated wake velocity field.Subsequently,Lidar-detected echoes of the velocity field are simulated to obtain a data set similar to the actual situation for model training.In the case study validation,real measured data underwent preprocessing and were then input into the established model.This allowed us to construct the wake vortex characteristic parameter inversion model.The final results demonstrated that our model achieved parameter inversion with only minor errors.In a practical example,our model in this paper significantly reduced the mean square error of the inverted velocity field when compared to the traditional algorithm.This study holds significant promise for real-time monitoring of wake vortices at airports,and is proved a crucial step in developing wake vortex interval standards.
基金Supported by State Key Research and Development Program of Ministry of Science and Technology(2017YFD0200808)National Undergraduate Training Program for Innovation and Entrepreneurship(201510410011)
文摘Chinese milk vetch （Astragalus sinicus L. ） is a conunonly used green manure crop in paddy fields in southern China and it has the effect of fostering fertility and soil. This paper firstly sununarized advances in research of new high quality and yield varieties of germplasm resources of Chinese milk vetch. Then, on the basis of current situation, it came up with recommendations for collection, storage and promotion, as well as application in the current ecological agriculture, including establishing germplasm resource bank and improving germplasm resource evaluation system.
文摘Although the electrospinning technique has been devoted to promoting therapeutic purposes as a drug carrier,however,there are still many fundamental problems in this area.This work focuses on a comparison of various diameter polyethersulfone(PES)electrospun ultrafine fibers as an-timicrobial materials.The fibrous morphology,antimicrobial agent distribution,thermally property,and biocompatibility evaluation of PES-based ultrafine fibers were systematically in-vestigated.The results demonstrated that the PES-based ultrafine fibers were suitable as anti-microbial material.Furthermore,the drug release behavior and mechanism were studied through total immersion.The release mechanism was confirmed to Fickian diffusion.It was revealed that the drug max release amount(71.5%)and release rate(7.71)are the highest for the smallest diameter ultrafine fibers.Meanwhile,the antimicrobial activity of PES ultrafine fibers is also inversely correlated with the diameter of fiber.The electrospun PES fibers would control their release behavior through the diameter and have a potential application in the wound dressings,such as chronic osteomyelitis and exposure injury.
基金Project supported by National Natural Science Foundation of China (21571095,61366004)。
文摘LaSr2 Mn2 O7,a Ruddlesden-Popper type bilayered perovskite,was investigated as oxygen catalyst for oxygen reduction reaction(ORR) and active electrode material for electrochemical capacitors in KOH solutions.XPS results show that Mn takes a mixed Mn2+,Mn3+and Mn4+valence state with an average valence of 3.4.As catalyst towards ORR,LaSr2 Mn2 O7 and LaSr2 Mn2 O7/acetylene black composite favor four electron pathways for ORR.LaSr2 Mn2 O7/C composite shows a comparable onset potential for ORR to that of Pt/C electrode.The improved ORR activity of LaSr2 Mn2 O7/acetylene black composite is attributed to the synergy between catalytic LaSr2 Mn2 O7 and conductive acetylene black.As electrode material for electrochemical capacitors,LaSr2 Mn2 O7 exhibits a maximum specific capacitance of 167.2 F/g with 62%faradic contribution at a scan rate of 1 mV/s in cyclic voltammetry test.
基金supported by the National Key Research and Development Program of China(2017YFC1404100,2017YFC1404104)the National Natural Science Foundation of China(41775100,41830964)+1 种基金the Shandong Province’s"Taishan"Scientist Project(2018012919)the collaborative project between the Ocean University of China(OUC),Texas A&M University(TAMU)and the National Center for Atmospheric Research(NCAR)and completed through the International Laboratory for High Resolution Earth System Prediction(iHESP)-a collaboration among QNLM,TAMU and NCAR。
文摘A regional coupled prediction system for the Asia-Pacific(AP-RCP)(38°E-180°,20°S-60°N) area has been established.The AP-RCP system consists of WRF-ROMS(Weather Research and Forecast,and Regional Ocean Model System) coupled models combined with local observational information through dynamically downscaling coupled data assimilation(CDA).The system generates 18-day forecasts for the atmosphere and ocean environment on a daily quasi-operational schedule at Pilot National Laboratory for Marine Science and Technology(Qingdao)(QNLM),consisting of 2 different-resolution coupled models:27 km WRF coupled with 9 km ROMS,9 km WRF coupled with 3 km ROMS,while a version of 3 km WRF coupled with 3 km ROMS is in a test mode.This study is a first step to evaluate the impact of high-resolution coupled model with dynamically downscaling CDA on the extended-range predictions,focusing on forecasts of typhoon onset,improved precipitation and typhoon intensity forecasts as well as simulation of the Kuroshio current variability associated with mesoscale oceanic activities.The results show that for realizing the extended-range predictability of atmospheric and oceanic environment characterized by statistics of mesoscale activities,a fine resolution coupled model resolving local mesoscale phenomena with balanced and coherent coupled initialization is a necessary first step.The next challenges include improving the planetary boundary physics and the representation of air-sea and air-land interactions to enable the model to resolve kilometer or sub-kilometer processes.
基金supported by the National Natural Science Foundation of China(Grant Nos.61902365 and 61902366)Open Project Program from Key Lab of Cryptologic Technology and Information Security,Ministry of Education,Shandong University.
文摘1 Introduction Key-value data,as NoSQL data widely used in recent years,has been frequently collected and used for analysis in major websites and mobile apps.The frequency distribution estimation on the key domain,as well as the mean estimation of values associated with the same key,are crucial and worth billion dollars in the business.However,in real applications,the key-value records are submitted by terminal devices of different users.Directly collecting the information from users may pose serious risks on personal privacy.On the other hand,the emerging shuffled differential privacy(SDP)model[1]is proposed to collect sensitive data from users.
基金supported by the National Natural Science Foundation of China(grant No.51803114)Shaanxi Province Key R&D Program(grant No.2022NY-195)+4 种基金Xi'an City Innovation Capability Strong Foundation Plan-Agricultural Technology R&D(grant No.21NYYF0025)Shaanxi Province Education Department Service Local Special Program Project(grant No.22jcO15)Shaanxi Province Key R&D Program(grant No.2020SF-411)Industry-University-Research Cooperation Project of Yulin Science and Technology Bureau(grant No.CXY-2020-086)National Key R&D Projects in 2021(grant No.2021YFC1808900).
文摘To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball method.The tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal stability.The stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were investigated.The results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.
基金This work was supported in part by the National Natural Science Foundation of China(No.81925034 and No.22237005)the Innovation Program of Shanghai Municipal Education Commission(No.2019-01-07-00-01-E00036,China)+4 种基金the Key Research and Development Program of Ningxia Hui Autonomous Region(No.2022CMG01002,China)the innovative research team of high-level local universities in Shanghai(Nos.SSMUZLCX20180702 and SHSMU-ZDCX20212700,China)the Natural Science Foundation of Ningxia(Nos.2022AAC02029 and 2021AAC03139,China)the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(No.SNZJU-SIAS-007,China)the open fund of state key laboratory of Pharmaceutical Biotechnology,Nanjing University(No.KF-202204,China).
文摘Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical practice.Unfortunately,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse reactions.As G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining momentum.Extensive research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse effects.This review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this treatment.We will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased agonists.It is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.
基金Xinjie Wang was supported by the Shandong Provincial Natu-ral Science Foundation of China(Grant No.ZR2021QF124)China Postdoctoral Science Foundation(Grant No.2021M703031)+2 种基金Qingdao Postdoctoral Applied Research Foundation,China,and the Open Project Program of the State Key Lab of CAD&CG(Grant No.A2219)Zhejiang University.Xiaogang Jin was supported by the National Natural Science Foundation of China(Grant No.62036010)Yucheng Wang was supported by the National Key Research and Development Program of China(Grant No.2020YFB0204804).
文摘Virtual marine scene authoring plays an important role in generating large-scale 3D scenes and it has a wide range of applications in computer animation and simulation.Existing marine scene authoring methods either produce periodic patterns or generate unnatural group distributions when tiling marine entities such as schools of fish and groups of reefs.To this end,we propose a new large-scale marine scene authoring method based on real examples in order to create more natural and realistic results.Our method first extracts the distribution of multiple marine entities from real images to create Octahedral Blocks,and then we use a modified Wang Cubes algorithm to quickly tile the 3D marine scene.As a result,our method is able to generate aperiodic tiling results with diverse distributions of density and orientation of entities.We validate the effectiveness of our method through intensive comparative experiments.User study results show that our method can generate satisfactory results which are in accord with human preferences.
基金supported by the National Key Research and Development Program of China(2021YFF0701700)the National Natural Science Foundation of China(22271299,22261132514)+1 种基金the Natural Science Foundation of Shandong Province(ZR2021LFG006)the State Key Laboratory of Fluorine-Containing Functional Membrane Materials。
文摘The divergent reductive cross-coupling with an ambident electrophile is rare.Previously,we demonstrated a nickel-catalyzed reductive 2-pyridination of aryl iodides with difluoromethyl 2-pyridyl sulfone(2-Py SO_(2)CF_(2)H)via selective C(sp^(2))-S bond cleavage of the sulfone by using a phosphine ligand.In this communication,we report a novel nickel-catalyzed reductive coupling of aryl iodides and 2-Py SO_(2)CF_(2)H reagent,which constitutes a new method for aromatic difluoromethylation.The use of a tridentate terpyridine ligand is pivotal for the selective C(sp^(3))-S bond cleavage of the sulfone.This method employs readily available nickel catalyst and 2-Py SO_(2)CF_(2)H as the difluoromethylation reagent,providing a facile access to difluoromethylarenes under mild reaction conditions without pre-generation of arylmetal reagents.
