Background： Erythropoiesis-stimulating agents （ESAs） are widely used in the management of anemia in cancer patients. Despite their apparent effectiveness, recent studies have suggested that ESAs could result in ser...Background： Erythropoiesis-stimulating agents （ESAs） are widely used in the management of anemia in cancer patients. Despite their apparent effectiveness, recent studies have suggested that ESAs could result in serious adverse events and even higher mortality. The aim of the current study was to evaluate the benefits and risks of ESAs in the management of cancer patients with anemia using a recta-analysis. Methods： The initial literature search covered Medline, PubMed, Embase, and the Cochrane Center Register of Controlled Trials, and identified 1,569 articles. The final meta-analysis included eight randomized controlled trials （n=2,387） in cancer patients with 〈11 g/dL hemoglobin （Hb） at the baseline and target Hb （for stopping ESA treatment） at no more than 13 g/dL. The assessment measures included Hb response, blood transfusion rate and adverse events that included venous thromboemblism （VTE）, hypertension, and on-study mortality. The results are expressed as pooled odds ratio （OR）. Publication bias was assessed using funnel plot analysis. Results： ESAs significantly increased the Hb concentration [OR 7.85, 95% confidence interval （CI）： 5.85 to 10.53, P〈O.O01] and reduced the red blood cell （RBC） transfusion rate （OR 0.52, 95% CI： 0.42 to 0.65, P〈0.001）. ESAs did not increase the accumulated adverse events （OR 0.95, P=0.82）, or the on-study mortality （OR 1.09, P=0.47）. Conclusions： ESAs are not associated with increased frequency of severe adverse events in anemic cancer patients when the target Hb value is no more than 13 g/dL.展开更多
Directed diffusion is a data dissemination protocol for wireless sensor networks. In directed diffusion, flooding is used for dissemination of interest and exploratory data, which will bring broadcast storm resulting ...Directed diffusion is a data dissemination protocol for wireless sensor networks. In directed diffusion, flooding is used for dissemination of interest and exploratory data, which will bring broadcast storm resulting in substantial energy consumption of networks. A grid-based directed diffusion is presented to improve the energy efficiency of directed diffusion. Virtual geographic grid clusters are constructed by self-organization of nodes using geographic location information. The flooding of interest and exploratory data of original directed diffusion is limited in cluster head nodes. The simulation results and testbed experiments show that the method effectively reduces the network energy consumption. This gain is not achieved at the cost of either delivery ratio or the delay. Importantly, the decreased load also leads to a better delivery ratio and lower delay.展开更多
The QR Code is a 2 dimensional matrix code with high error correction capability. It employs RS codes to generate error correction codewords in encoding and recover errors and damages in decoding. This paper presents ...The QR Code is a 2 dimensional matrix code with high error correction capability. It employs RS codes to generate error correction codewords in encoding and recover errors and damages in decoding. This paper presents several QR Code’s virtues, analyzes RS decoding algorithm and gives a software flow chart of decoding the QR Code with RS decoding algorithm.展开更多
基金supported by the Development Projects of Science and Technology of Shandong Province, China (2012GGE27073)
文摘Background： Erythropoiesis-stimulating agents （ESAs） are widely used in the management of anemia in cancer patients. Despite their apparent effectiveness, recent studies have suggested that ESAs could result in serious adverse events and even higher mortality. The aim of the current study was to evaluate the benefits and risks of ESAs in the management of cancer patients with anemia using a recta-analysis. Methods： The initial literature search covered Medline, PubMed, Embase, and the Cochrane Center Register of Controlled Trials, and identified 1,569 articles. The final meta-analysis included eight randomized controlled trials （n=2,387） in cancer patients with 〈11 g/dL hemoglobin （Hb） at the baseline and target Hb （for stopping ESA treatment） at no more than 13 g/dL. The assessment measures included Hb response, blood transfusion rate and adverse events that included venous thromboemblism （VTE）, hypertension, and on-study mortality. The results are expressed as pooled odds ratio （OR）. Publication bias was assessed using funnel plot analysis. Results： ESAs significantly increased the Hb concentration [OR 7.85, 95% confidence interval （CI）： 5.85 to 10.53, P〈O.O01] and reduced the red blood cell （RBC） transfusion rate （OR 0.52, 95% CI： 0.42 to 0.65, P〈0.001）. ESAs did not increase the accumulated adverse events （OR 0.95, P=0.82）, or the on-study mortality （OR 1.09, P=0.47）. Conclusions： ESAs are not associated with increased frequency of severe adverse events in anemic cancer patients when the target Hb value is no more than 13 g/dL.
基金the National High Technology Research and Development Programme of China(No.2002AA142020)the National Natural Science Foundation of China(No.60475012)
文摘Directed diffusion is a data dissemination protocol for wireless sensor networks. In directed diffusion, flooding is used for dissemination of interest and exploratory data, which will bring broadcast storm resulting in substantial energy consumption of networks. A grid-based directed diffusion is presented to improve the energy efficiency of directed diffusion. Virtual geographic grid clusters are constructed by self-organization of nodes using geographic location information. The flooding of interest and exploratory data of original directed diffusion is limited in cluster head nodes. The simulation results and testbed experiments show that the method effectively reduces the network energy consumption. This gain is not achieved at the cost of either delivery ratio or the delay. Importantly, the decreased load also leads to a better delivery ratio and lower delay.
文摘The QR Code is a 2 dimensional matrix code with high error correction capability. It employs RS codes to generate error correction codewords in encoding and recover errors and damages in decoding. This paper presents several QR Code’s virtues, analyzes RS decoding algorithm and gives a software flow chart of decoding the QR Code with RS decoding algorithm.
